TSLP signaling pathway (WP3191)

Bos taurus

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Thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine involved in regulation of a broad spectrum of biological processes. The TSLP receptor complex consists of the IL-7 receptor alpha subunit and its unique TSLPR subunit (gene symbol CRLF2). TSLP can be secreted by epithelial cells upon pathogen stimulation. TSLP can also activate dendritic cells, CD4+ T cells and CD8+ T cells. TSLP not only activate the JAK/STAT pathway but also induce phosphorylation of other signaling molecules including PI3K/Akt, ERK1/2 and JNKs. Aberrant TSLP signaling is implicated in a number of the development of diseases, including asthma, atopic dermatitis, eosinophilic eosophagitis and acute lymphoid leukemia. Description source: NetPath

Authors

Martina Summer-Kutmon , Egon Willighagen , Kristina Hanspers , and Eric Weitz

Activity

last edited pathway curation

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Cited In

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

cytokine mediated signaling pathway interleukin-2 family mediated signaling pathway Jak-Stat signaling pathway

Participants

Label Type Compact URI Comment
MAP2K2 Protein ensembl:ENSBTAG00000024450 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605
MAPK3 Protein ensembl:ENSBTAG00000016156 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595
CRLF2 Protein ensembl:ENSBTAG00000020242 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64109
STAT1 Protein ensembl:ENSBTAG00000007867 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
STAT3 Protein ensembl:ENSBTAG00000021523 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774
STAT4 Protein ensembl:ENSBTAG00000046699 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6775
PIK3CA Protein ensembl:ENSBTAG00000009232 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5290
AKT1 Protein ensembl:ENSBTAG00000017636 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207
MAPK1 Protein ensembl:ENSBTAG00000010312 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
MTOR Protein ensembl:ENSBTAG00000015325 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2475
RPS6 Protein ensembl:ENSBTAG00000014449 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6194
PTPN11 Protein ensembl:ENSBTAG00000002048 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5781
JAK2 Protein ensembl:ENSBTAG00000012047 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3717
JAK1 Protein ensembl:ENSBTAG00000003147 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3716
IL7R Protein ensembl:ENSBTAG00000019975 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3575
MAP2K1 Protein ensembl:ENSBTAG00000033983 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604
MAPK14 Protein ensembl:ENSBTAG00000020783 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1432
EIF4EBP1 Protein ensembl:ENSBTAG00000027654 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1978
BIKBA Protein ensembl:ENSBTAG00000016683 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4792
RELB Protein ensembl:ENSBTAG00000038428 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5971
RELA Protein ensembl:ENSBTAG00000013895 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5970
NFKB1 Protein ensembl:ENSBTAG00000020270 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4790
NFKB2 Protein ensembl:ENSBTAG00000006017 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4791
MAPK8 Protein ensembl:ENSBTAG00000007876 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5599
TEC Protein ensembl:ENSBTAG00000005062 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7006
PI4K2A Protein ensembl:ENSBTAG00000002010 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55361
STAT6 Protein ensembl:ENSBTAG00000006335 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6778
SRC Protein ensembl:ENSBTAG00000008938 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6714
STAT5B Protein ensembl:ENSBTAG00000010125 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6777
STAT5A Protein ensembl:ENSBTAG00000009496 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6776
MAPK9 Protein ensembl:ENSBTAG00000004709 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5601
YES1 Protein ensembl:ENSBTAG00000001523 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7525
LCK Protein ensembl:ENSBTAG00000012695 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3932
BTK Protein ensembl:ENSBTAG00000019250 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:695
FES Protein ensembl:ENSBTAG00000002941 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2242
HCK Protein ensembl:ENSBTAG00000007932 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3055
FYN Protein ensembl:ENSBTAG00000011851 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2534
LYN Protein ensembl:ENSBTAG00000020034 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4067

References