Felbamate metabolism (WP2816)

Homo sapiens

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CYP metabolism of felbamate.

Authors

Egon Willighagen , Kristina Hanspers , Martina Summer-Kutmon , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

nervous system drug pathway xenobiotic metabolic pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
atropaldehyde Metabolite pubchem.compound:10312
3-Hydroxy-2-phenylpropylcarbamate Metabolite chemspider:184751
3-carbamoyl-2-phenylpropionic acid Metabolite pubchem.compound:3025746
3-carbamoyl-2-phenylpropionaldehyde Metabolite pubchem.compound:21350391
p-hydroxyfelbamate Metabolite chemspider:8096945
Felbamate Metabolite hmdb:HMDB0015084
2-hydroxyfelbamate Metabolite chemspider:8575477
CYP3A4 GeneProduct ensembl:ENSG00000160868
CYP2E1 GeneProduct ensembl:ENSG00000130649
1.1.1.1 Protein eccode:1.1.1.1
1.2.1.5 Protein eccode:1.2.1.5

References

  1. Pharmacokinetic interactions with felbamate. In vitro-in vivo correlation. Glue P, Banfield CR, Perhach JL, Mather GG, Racha JK, Levy RH. Clin Pharmacokinet. 1997 Sep;33(3):214–24. PubMed Europe PMC Scholia
  2. Felbamate-induced apoptosis of hematopoietic cells is mediated by redox-sensitive and redox-independent pathways. Husain Z, Pinto C, Sofia RD, Yunis EJ. Epilepsy Res. 2002 Jan;48(1–2):57–69. PubMed Europe PMC Scholia