Selenium micronutrient network (WP1310)
Rattus norvegicus
The selenium-centred micronutrient biological network. The most relevant biochemical processes related to selenium in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying the selenium centred plasma metabolome. A selenoprotein database exists at: http://www.selenodb.org.
Authors
Egon Willighagen , Linda Rieswijk , and Eric WeitzActivity
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Organisms
Rattus norvegicusCommunities
Annotations
Pathway Ontology
selenoamino acid metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| ALA (n-3) | Metabolite | hmdb:HMDB0001388 | |
| glutathione disulfide | Metabolite | hmdb:HMDB0000656 | |
| C22:5 (n-6) | Metabolite | hmdb:HMDB0001976 | |
| Thromboxane B2 | Metabolite | hmdb:HMDB0003252 | |
| NADP | Metabolite | hmdb:HMDB0000217 | |
| NADPH | Metabolite | hmdb:HMDB0000221 | |
| Glutathione | Metabolite | hmdb:HMDB0000125 | |
| Uric Acid | Metabolite | hmdb:HMDB0000289 | |
| Leukotriene C4 | Metabolite | hmdb:HMDB0001198 | |
| Riboflavin | Metabolite | hmdb:HMDB0000244 | |
| Leukotriene F4 | Metabolite | hmdb:HMDB0006465 | |
| Leukotriene A4 | Metabolite | hmdb:HMDB0001337 | |
| Folic acid | Metabolite | hmdb:HMDB0000121 | |
| Vitamin B12 | Metabolite | hmdb:HMDB0002174 | |
| Leukotriene D4 | Metabolite | hmdb:HMDB0003080 | |
| Tromboxane A2 | Metabolite | hmdb:HMDB0001452 | |
| Leukotriene E4 | Metabolite | hmdb:HMDB0002200 | |
| iPF2-alpha | Metabolite | hmdb:HMDB0004659 | |
| NADP | Metabolite | hmdb:HMDB0000217 | |
| PGD2 | Metabolite | hmdb:HMDB0001403 | |
| Leukotriene B4 | Metabolite | hmdb:HMDB0001085 | |
| Glutathione | Metabolite | hmdb:HMDB0000125 | |
| Folic acid | Metabolite | hmdb:HMDB0000121 | |
| Methionine | Metabolite | hmdb:HMDB0000696 | |
| ALA (n-3) | Metabolite | hmdb:HMDB0001388 | |
| F2-Isoprostane | Metabolite | hmdb:HMDB0004659 | |
| AA (n-6) | Metabolite | hmdb:HMDB0001043 | |
| Ascorbic acid | Metabolite | hmdb:HMDB0000044 | |
| H2O | Metabolite | hmdb:HMDB0002111 | |
| Xanthine | Metabolite | hmdb:HMDB0000292 | |
| C22:5 (n-6) | Metabolite | hmdb:HMDB0001976 | |
| a-tocopherol | Metabolite | hmdb:HMDB0001893 | |
| LA (n-6) | Metabolite | hmdb:HMDB0000673 | |
| AA (n-6) | Metabolite | hmdb:HMDB0001043 | |
| Methionine sulfoxide | Metabolite | hmdb:HMDB0002005 | |
| PGI2 | Metabolite | hmdb:HMDB0001335 | |
| Leukotriene D4 | Metabolite | hmdb:HMDB0003080 | |
| EPA (n-3) | Metabolite | hmdb:HMDB0001999 | |
| a-Tocopherol | Metabolite | hmdb:HMDB0001893 | |
| Pyridoxal 5'-phosphate | Metabolite | hmdb:HMDB0001491 | |
| PGH2 | Metabolite | hmdb:HMDB0001381 | |
| Iron | Metabolite | hmdb:HMDB0000692 | |
| Homocysteine | Metabolite | hmdb:HMDB0000742 | |
| Leukotriene C4 | Metabolite | hmdb:HMDB0001198 | |
| Zinc | Metabolite | hmdb:HMDB0015532 | |
| LeukotrieneE4 | Metabolite | hmdb:HMDB0002200 | |
| PGF2a | Metabolite | hmdb:HMDB0001139 | |
| O2 | Metabolite | hmdb:HMDB0001377 | |
| Iron | Metabolite | hmdb:HMDB0000692 | |
| Homocysteine | Metabolite | hmdb:HMDB0000742 | |
| Heme | Metabolite | hmdb:HMDB0003178 | |
| Manganese | Metabolite | hmdb:HMDB0001333 | |
| Tryptophan | Metabolite | hmdb:HMDB0000929 | |
| Ascorbic acid | Metabolite | hmdb:HMDB0000044 | |
| 15-HETE | Metabolite | hmdb:HMDB0011134 | |
| Pyridoxal 5'-phosphate | Metabolite | hmdb:HMDB0001491 | |
| Selenium | Metabolite | hmdb:HMDB0001349 | |
| NADPH | Metabolite | hmdb:HMDB0000221 | |
| EPA (n-3) | Metabolite | hmdb:HMDB0001999 | |
| 5-HPETE | Metabolite | hmdb:HMDB0001193 | |
| Hypoxanthine | Metabolite | hmdb:HMDB0000157 | |
| Lipoic acid | Metabolite | hmdb:HMDB0001451 | |
| Zinc | Metabolite | hmdb:HMDB0015532 | |
| Selenium | Metabolite | hmdb:HMDB0001349 | |
| Methionine | Metabolite | hmdb:HMDB0000696 | |
| PGI2 | Metabolite | hmdb:HMDB0001335 | |
| Vitamin B12 | Metabolite | hmdb:HMDB0002174 | |
| Lipoxin B4 | Metabolite | hmdb:HMDB0005082 | |
| Thromboxane A2 | Metabolite | hmdb:HMDB0001452 | |
| Leukotriene B4 | Metabolite | hmdb:HMDB0001085 | |
| H2O2 | Metabolite | hmdb:HMDB0003125 | |
| DHA (n-3) | Metabolite | hmdb:HMDB0002183 | |
| Lipoxin A4 | Metabolite | hmdb:HMDB0004385 | |
| LA (n-6) | Metabolite | hmdb:HMDB0000673 | |
| PGG2 | Metabolite | hmdb:HMDB0003235 | |
| FAD | Metabolite | hmdb:HMDB0001248 | |
| PGF2a | Metabolite | hmdb:HMDB0001139 | |
| PGD2 | Metabolite | hmdb:HMDB0001403 | |
| Cysteine | Metabolite | hmdb:HMDB0000574 | |
| DHA (n-3) | Metabolite | hmdb:HMDB0002183 | |
| Cysteine | Metabolite | hmdb:HMDB0000574 | |
| Niacin | Metabolite | hmdb:HMDB0001406 | |
| Hypoxanthine | Metabolite | hmdb:HMDB0000157 | |
| Copper | Metabolite | hmdb:HMDB0000657 | |
| ROS | Metabolite | wikidata:Q424361 | http://en.wikipedia.org/wiki/Reactive_Oxygen_Species |
| Lipoxin A4 | Metabolite | hmdb:HMDB0004385 | |
| PGE3 | Metabolite | hmdb:HMDB0002664 | |
| 15-HETE | Metabolite | hmdb:HMDB0011134 | |
| Copper | Metabolite | hmdb:HMDB0000657 | |
| TRXR 2 | GeneProduct | ncbigene:10587 | |
| FMN | GeneProduct | ncbigene:342184 | |
| SelR | GeneProduct | ncbigene:51734 | |
| T | GeneProduct | ncbigene:292301 | |
| T | GeneProduct | ncbigene:292301 | |
| TRXR 1 | GeneProduct | ncbigene:7296 | |
| SelW | GeneProduct | ncbigene:6415 | |
| TRXR 3 | GeneProduct | ncbigene:114112 | |
| Gpx1 | Protein | ncbigene:24404 | |
| Ptgds | Protein | ncbigene:25526 | |
| Alox5 | Protein | ncbigene:25290 | |
| COX1 | Protein | ncbigene:26195 | |
| Gsr | Protein | ensembl:ENSRNOG00000014915 | |
| PNPO | Protein | ncbigene:64533 | |
| Ptgis | Protein | ncbigene:25527 | |
| Sod1 | Protein | ncbigene:24786 | |
| Ptges | Protein | ncbigene:59103 | |
| Tbxas1 | Protein | ncbigene:24886 | |
| Mthfr | Protein | ncbigene:362657 | |
| Thioredoxin | Protein | ncbigene:7295 | |
| Kmo | Protein | ncbigene:59113 | |
| Gpx2 | Protein | ncbigene:29326 | |
| Fads2 | Protein | ncbigene:83512 | |
| Sepp1 | Protein | ncbigene:29360 | |
| Gpx6 | Protein | ncbigene:259233 | |
| Selk | Protein | ncbigene:290549 | |
| Xdh | Protein | ncbigene:497811 | |
| Mtr | Protein | ncbigene:81522 | |
| Fads1 | Protein | ncbigene:84575 | |
| COX2 | Protein | ncbigene:26198 | |
| Cat | Protein | ncbigene:24248 | |
| Gpx3 | Protein | ncbigene:64317 | |
| Gpx4 | Protein | ncbigene:29328 |
References
- Synthesis and biological activities of leukotriene F4 and leukotriene F4 sulfone. Denis D, Charleson S, Rackham A, Jones TR, Ford-Hutchinson AW, Lord A, et al. Prostaglandins. 1982 Dec;24(6):801–14. PubMed Europe PMC Scholia
- Nitric oxide and superoxide in inflammation and immune regulation. Guzik TJ, Korbut R, Adamek-Guzik T. J Physiol Pharmacol. 2003 Dec;54(4):469–87. PubMed Europe PMC Scholia