Osteoblast signaling (WP227)

Rattus norvegicus

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Osteoblasts are specialized, terminally differentiated uninucleated cells responsible for bone formation. Their activity is tightly regulated by external stimuli, originating from e.g. the parathyroid glands, osteocytes, etc. Along with osteoclasts, which are responsible for bone degradation, osteoblasts are key regulators of the shape and volume of bone tissue.

Authors

Ed Hsiao , Alex Pico , Kristina Hanspers , Daniela Digles , Martina Summer-Kutmon , Eric Weitz , Egon Willighagen , and Denise Slenter

Activity

last edited

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Organisms

Rattus norvegicus

Communities

Annotations

Cell Type Ontology

osteoblast

Pathway Ontology

signaling pathway pertinent to development

Participants

Label Type Compact URI Comment
Vitamin D Metabolite chebi:27300
Sodium Metabolite chebi:29101
Phosphate Metabolite chebi:18367
Parathyroid hormone GeneProduct ncbigene:24694
Osteoprotegerin GeneProduct ncbigene:25341
RANK ligand GeneProduct ncbigene:117516
Bone sialoprotein GeneProduct ncbigene:25295
PTH receptor GeneProduct ncbigene:56813
PDGF Ra GeneProduct ncbigene:25267
FGF-23 GeneProduct ncbigene:170583
Collagen 1 GeneProduct ncbigene:29393
NPT3 GeneProduct ncbigene:25548
Osteocalcin GeneProduct ncbigene:25295
PDGF Rb GeneProduct ncbigene:24629

References

  1. Vitamin D3 Modulates Impaired Crosstalk Between RANK and Glucocorticoid Receptor Signaling in Bone Marrow Cells After Chronic Prednisolone Administration. Shymanskyi I, Lisakovska O, Mazanova A, Labudzynskyi D, Veliky M. Front Endocrinol (Lausanne). 2018 Jun 7;9:303. PubMed Europe PMC Scholia