Phase I biotransformations, non-P450 (WP136)

Homo sapiens

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This pathway lists several phase 1 biotransformations and their related enzymes. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP136 CPTAC Assay Portal]

Authors

Rollie , Thomas Kelder , Chris Evelo , Kristina Hanspers , Egon Willighagen , Zahra Roudbari , Martina Summer-Kutmon , Marvin Martens , and Eric Weitz

Activity

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

cytochrome P450-independent phase I biotransformation pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
thio esters Metabolite chebi:51277
Phosphoric acid esters Metabolite chebi:37734
thio esters Metabolite chebi:51277
carboxylic acid esters Metabolite chebi:33308
amides Metabolite chebi:32988
carboxylic acid esters Metabolite chebi:33308
Phosphoric acid esters Metabolite chebi:37734
amides Metabolite chebi:32988
CES7 GeneProduct ensembl:ENSG00000159398
ESD GeneProduct ensembl:ENSG00000139684
LIPA GeneProduct ensembl:ENSG00000107798
PON3 GeneProduct ensembl:ENSG00000105852
CES2 GeneProduct ensembl:ENSG00000172831
PON2 GeneProduct ensembl:ENSG00000105854
CES1 GeneProduct ensembl:ENSG00000198848
PON1 GeneProduct ensembl:ENSG00000005421

References

  1. Casarett & Doull’s Essentials of Toxicology [Internet]. Klaassen C, Watkins JB III. McGraw-Hill Professional; 2003. 548 p. Available from: https://books.google.com/books/about/Casarett_Doull_s_Essentials_of_Toxicolog.html?hl=&id=pj5iQgAACAAJ OpenLibrary Worldcat