Novel intracellular components of RIG-I-like receptor pathway (WP3865)
Homo sapiens
Viral pathogen RNA are recognized by host helicases called RIG-I-like receptors (RLRs) that include DDX58 (RIG-I), DHX58 (LGP2), IFIH1 (MDA5), SNW1, and DDX17. These RLR proteins then go on to initiate signaling pathways, triggering the innate antiviral response via production of type I interferons and inflammatory cytokines. RLR pathway genes are characterized by rapid evolution, viral protein interactions, limited sets of protein domains, specific TF regulation, and densely connected interaction networks. The study by van der Lee et al. (2015) identfied novel components, DDX17 and SNW1, for the RIG-I pathway. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3865 CPTAC Assay Portal]
Authors
Alex Pico , Yt , Kristina Hanspers , and Egon WillighagenActivity
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Cited In
- Understanding signaling and metabolic paths using semantified and harmonized information about biological interactions (2022).
- Modulation of stress and immune response by Amblyomin-X results in tumor cell death in a horse melanoma model (2020).
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
signaling pathway signaling pathway in the innate immune responseDisease Ontology
viral infectious diseaseReferences
- Integrative Genomics-Based Discovery of Novel Regulators of the Innate Antiviral Response. van der Lee R, Feng Q, Langereis MA, Ter Horst R, Szklarczyk R, Netea MG, et al. PLoS Comput Biol. 2015 Oct 20;11(10):e1004553. PubMed Europe PMC Scholia