Serotonin receptor 2 and STAT3 signaling (WP3115)

Bos taurus

Open in new tab Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
This pathway depicts the downstream signaling of serotonin via receptor 2A, resulting in the activation of STAT3.

Authors

Martina Summer-Kutmon , Egon Willighagen , Eric Weitz , and Alex Pico

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

serotonin signaling pathway

Cell Type Ontology

neuron

Participants

Label Type Compact URI Comment
serotonin Metabolite cas:50-67-9
HTR2A GeneProduct ensembl:ENSBTAG00000013498 5-hydroxytryptamine (serotonin) receptor 2A
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3356
JAK2 GeneProduct ensembl:ENSBTAG00000012047 Janus kinase 2
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3717
GNAQ GeneProduct ensembl:ENSBTAG00000009789 guanine nucleotide binding protein, alpha q polypeptide
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2776
STAT3 GeneProduct ensembl:ENSBTAG00000021523 signal transducer and activator of transcription
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774

References

  1. Neomycin selectively inhibits 5-hydroxytryptamine-induced contraction in the guinea pig trachea. Cox DA, Watts SW, Cohen ML. J Pharmacol Exp Ther. 1996 May;277(2):954–9. PubMed Europe PMC Scholia
  2. Lack of efficacy of 5-HT2A receptor antagonists to reduce brain damage after 3 minutes of transient global cerebral ischaemia in gerbils. Piera MJ, Beaughard M, Michelin MT, Winslow E, Massingham R. Fundam Clin Pharmacol. 1995;9(6):562–8. PubMed Europe PMC Scholia
  3. Serotonin activates electrolyte transport via 5-HT2A receptor in rat colonic crypt cells. Imada-Shirakata Y, Kotera T, Ueda S, Okuma M. Biochem Biophys Res Commun. 1997 Jan 13;230(2):437–41. PubMed Europe PMC Scholia
  4. Identification and localization of a skeletal muscle secrotonin 5-HT2A receptor coupled to the Jak/STAT pathway. Guillet-Deniau I, Burnol AF, Girard J. J Biol Chem. 1997 Jun 6;272(23):14825–9. PubMed Europe PMC Scholia
  5. Mechanisms of serotonin-induced Ca2+ responses in mesangial cells. Goppelt-Struebe M, Stroebel M. Naunyn Schmiedebergs Arch Pharmacol. 1997 Aug;356(2):240–7. PubMed Europe PMC Scholia
  6. Fluoxetine gradually increases [125I]DOI-labelled 5-HT2A/2C receptors in the hypothalamus without changing the levels of Gq- and G11-proteins. Li Q, Muma NA, Battaglia G, Van de Kar LD. Brain Res. 1997 Nov 14;775(1–2):225–8. PubMed Europe PMC Scholia
  7. Sexual functioning in depressed outpatients taking mirtazapine. Boyarsky BK, Haque W, Rouleau MR, Hirschfeld RM. Depress Anxiety. 1999;9(4):175–9. PubMed Europe PMC Scholia
  8. Occurrence of a transcription factor, signal transducer and activators of transcription 3 (Stat3), in the postsynaptic density of the rat brain. Murata S, Usuda N, Okano A, Kobayashi S, Suzuki T. Brain Res Mol Brain Res. 2000 May 31;78(1–2):80–90. PubMed Europe PMC Scholia
  9. The information content of spontaneous retinal waves. Butts DA, Rokhsar DS. J Neurosci. 2001 Feb 1;21(3):961–73. PubMed Europe PMC Scholia
  10. Role of STAT3 in ischemic preconditioning. Hattori R, Maulik N, Otani H, Zhu L, Cordis G, Engelman RM, et al. J Mol Cell Cardiol. 2001 Nov;33(11):1929–36. PubMed Europe PMC Scholia
  11. Chronic fluoxetine differentially affects 5-hydroxytryptamine (2A) receptor signaling in frontal cortex, oxytocin- and corticotropin-releasing factor-containing neurons in rat paraventricular nucleus. Damjanoska KJ, Van de Kar LD, Kindel GH, Zhang Y, D’Souza DN, Garcia F, et al. J Pharmacol Exp Ther. 2003 Aug;306(2):563–71. PubMed Europe PMC Scholia
  12. The sleep inducing brain lipid cis-oleamide (cOA) does not modulate serotonergic transmission in the CA1 pyramidal neurons of the hippocampus in vitro. Dougalis A, Lees G, Ganellin CR. Neuropharmacology. 2004 Jan;46(1):63–73. PubMed Europe PMC Scholia
  13. Interleukin-6-induced JAK2/STAT3 signaling pathway in endothelial cells is suppressed by hemodynamic flow. Ni CW, Hsieh HJ, Chao YJ, Wang DL. Am J Physiol Cell Physiol. 2004 Sep;287(3):C771-80. PubMed Europe PMC Scholia
  14. Signal transducer and activator of transcription 3 activation by the delta-opioid receptor via Galpha14 involves multiple intermediates. Lo RKH, Wong YH. Mol Pharmacol. 2004 Jun;65(6):1427–39. PubMed Europe PMC Scholia
  15. Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling. Kamakura S, Oishi K, Yoshimatsu T, Nakafuku M, Masuyama N, Gotoh Y. Nat Cell Biol. 2004 Jun;6(6):547–54. PubMed Europe PMC Scholia
  16. A novel mechanism for JAK2 activation by a G protein-coupled receptor, the CCK2R: implication of this signaling pathway in pancreatic tumor models. Ferrand A, Kowalski-Chauvel A, Bertrand C, Escrieut C, Mathieu A, Portolan G, et al. J Biol Chem. 2005 Mar 18;280(11):10710–5. PubMed Europe PMC Scholia
  17. Hepatitis C virus (HCV) constitutively activates STAT-3 via oxidative stress: role of STAT-3 in HCV replication. Waris G, Turkson J, Hassanein T, Siddiqui A. J Virol. 2005 Feb;79(3):1569–80. PubMed Europe PMC Scholia
  18. A SOCS-1 peptide mimetic inhibits both constitutive and IL-6 induced activation of STAT3 in prostate cancer cells. Flowers LO, Subramaniam PS, Johnson HM. Oncogene. 2005 Mar 17;24(12):2114–20. PubMed Europe PMC Scholia