p38 Mapk signaling pathway (WP350)

Mus musculus

p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, Cdc42). As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activated MKK3/5, the p38 MAPK kinase. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. P38 MAK is involved in regulation of Hsp27 and MAPKAP-2 and several transcription factors including ATF2, STAT1, THE Max/Myc complex, MEF-2, ELK-1 and indirectly CREB via activation of MSK1.

Authors

Sebastien Burel , Kristina Hanspers , Daniela Digles , Alex Pico , Martina Summer-Kutmon , Denise Slenter , Eric Weitz , and Egon Willighagen

Activity

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Cited In

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

p38 MAPK signaling pathway

Participants

Label Type Compact URI Comment
Mapkapk2 GeneProduct ensembl:ENSMUSG00000016528 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:9261
Grb2 GeneProduct ensembl:ENSMUSG00000059923 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2885
Traf2 GeneProduct ensembl:ENSMUSG00000026942 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7186
Gm42878 GeneProduct ensembl:ENSMUSG00000105340 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8550
Hspb1 GeneProduct ensembl:ENSMUSG00000004951 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3315
Shc1 GeneProduct ensembl:ENSMUSG00000042626 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6464
Map2k6 GeneProduct ensembl:ENSMUSG00000020623 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5608
Map3k9 GeneProduct ensembl:ENSMUSG00000042724 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4293
Rac1 GeneProduct ensembl:ENSMUSG00000001847 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5879
Tgfbr1 GeneProduct ensembl:ENSMUSG00000007613 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7046
Mef2d GeneProduct ensembl:ENSMUSG00000001419 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4209
Atf2 GeneProduct ensembl:ENSMUSG00000027104 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1386
Stat1 GeneProduct ensembl:ENSMUSG00000026104 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6772
Creb1 GeneProduct ensembl:ENSMUSG00000025958 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1385
Map3k5 GeneProduct ensembl:ENSMUSG00000071369 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4217
Mknk1 GeneProduct ensembl:ENSMUSG00000028708 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8569
Map3k7 GeneProduct ensembl:ENSMUSG00000028284 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6885
Ripk1 GeneProduct ensembl:ENSMUSG00000021408 receptor (TNFRSF)-interacting serine-threonine kinase 1
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8737
Rps6ka5 GeneProduct ensembl:ENSMUSG00000021180 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:9252
Mapk14 GeneProduct ensembl:ENSMUSG00000053436 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1432
Elk1 GeneProduct ensembl:ENSMUSG00000009406 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2002
Max GeneProduct ensembl:ENSMUSG00000059436 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4149
Hras GeneProduct ensembl:ENSMUSG00000025499 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3265
Cdc42 GeneProduct ensembl:ENSMUSG00000006699 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:998
Hmgn1 GeneProduct ensembl:ENSMUSG00000040681 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3150
Pla2g4a GeneProduct ensembl:ENSMUSG00000056220 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5321
Map2k4 GeneProduct ensembl:ENSMUSG00000033352 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6416
Ddit3 GeneProduct ensembl:ENSMUSG00000025408 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1649
Rasgrf1 GeneProduct ensembl:ENSMUSG00000032356 PDZ domain containing guanine nucleotide exchange
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5923
Tgfb2 GeneProduct ensembl:ENSMUSG00000039239 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7042
Daxx GeneProduct ensembl:ENSMUSG00000002307 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1616
Map3k1 GeneProduct ensembl:ENSMUSG00000021754 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4214
Myc GeneProduct ensembl:ENSMUSG00000022346 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4609
Tradd GeneProduct ensembl:ENSMUSG00000031887 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8717

References

  1. Activation of the p38 mitogen-activated protein kinase pathway by gonadotropin-releasing hormone. Roberson MS, Zhang T, Li HL, Mulvaney JM. Endocrinology. 1999 Mar;140(3):1310–8. PubMed Europe PMC Scholia
  2. Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression. Wysk M, Yang DD, Lu HT, Flavell RA, Davis RJ. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3763–8. PubMed Europe PMC Scholia
  3. Making the connection: coupling of stress-activated ERK/MAPK (extracellular-signal-regulated kinase/mitogen-activated protein kinase) core signalling modules to extracellular stimuli and biological responses. Kyriakis JM. Biochem Soc Symp. 1999;64:29–48. PubMed Europe PMC Scholia
  4. The stress-activated protein kinase pathways. Tibbles LA, Woodgett JR. Cell Mol Life Sci. 1999 Aug 15;55(10):1230–54. PubMed Europe PMC Scholia
  5. p38 MAPK signalling cascades in inflammatory disease. Herlaar E, Brown Z. Mol Med Today. 1999 Oct;5(10):439–47. PubMed Europe PMC Scholia
  6. Cell-type-specific activation of p38 protein kinase cascades by the novel tumor promoter palytoxin. Li S, Wattenberg EV. Toxicol Appl Pharmacol. 1999 Oct 15;160(2):109–19. PubMed Europe PMC Scholia
  7. From receptors to stress-activated MAP kinases. Ichijo H. Oncogene. 1999 Nov 1;18(45):6087–93. PubMed Europe PMC Scholia
  8. Identification of novel MAP kinase pathway signaling targets by functional proteomics and mass spectrometry. Lewis TS, Hunt JB, Aveline LD, Jonscher KR, Louie DF, Yeh JM, et al. Mol Cell. 2000 Dec;6(6):1343–54. PubMed Europe PMC Scholia