Electron transport chain: OXPHOS system in mitochondria (WP111)

Homo sapiens

Authors

Kdahlquist , Alex Pico , Kristina Hanspers , Ferry Jagers , Christine Chichester , Egon Willighagen , Martina Summer-Kutmon , Denise Slenter , Eric Weitz , and Aishwarya Iyer

Activity

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Cited In

• The Human Cell Atlas bone marrow single-cell interactive web portal.
• A Pilot Mitochondrial Genome-Wide Association on Migraine Among Saudi Arabians (2022).
• Network-Assisted Systems Biology Analysis of the Mitochondrial Proteome in a Pre-Clinical Model of Ischemia, Revascularization and Post-Conditioning (2022).
• DNA methylation of ARHGAP30 is negatively associated with ARHGAP30 expression in lung adenocarcinoma, which reduces tumor immunity and is detrimental to patient survival (2021).
• ConsensusPathDB 2022: molecular interactions update as a resource for network biology (2022).
• Extensive alternative splicing triggered by mitonuclear mismatch in naturally introgressed Rhinolophus bats (2021).
• Reduced mGluR5 Activity Modulates Mitochondrial Function (2021).
• Heterogeneity of Lipid and Protein Cartilage Profiles Associated with Human Osteoarthritis with or without Type 2 Diabetes Mellitus (2021).
• WikiPathways: connecting communities (2021).
• Skeletal muscle reprogramming by breast cancer regardless of treatment history or tumor molecular subtype (2020).
• Phenotypic and functional characterization of corneal endothelial cells during in vitro expansion (2020).
• Granule Cell Dispersion in Human Temporal Lobe Epilepsy: Proteomics Investigation of Neurodevelopmental Migratory Pathways (2020).
• Mitochondrial Oxidative Phosphorylation Complex Regulates NLRP3 Inflammasome Activation and Predicts Patient Survival in Nasopharyngeal Carcinoma* (2020).
• Pathway analysis of transcriptomic data shows immunometabolic effects of vitamin D (2018).
• Pre-silencing of genes involved in the electron transport chain (ETC) pathway is associated with responsiveness to abatacept in rheumatoid arthritis (2017).
• RNA-Seq analysis of seasonal and individual variation in blood transcriptomes of healthy managed bottlenose dolphins (2016).
• Clinical improvement of DM1 patients reflected by reversal of disease-induced gene expression in blood (2022).
• A patient-based iPSC-derived hepatocyte model of alcohol-associated cirrhosis reveals bioenergetic insights into disease pathogenesis (2024).
• Integrative epigenetic profiling analysis identifies DNA methylation changes associated with chronic alcohol consumption (2015).
• Parallel use of human stem cell lung and heart models provide insights for SARS-CoV-2 treatment (2023).

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

electron transport chain pathway classic metabolic pathway

References

1. NDUFA4 is a subunit of complex IV of the mammalian electron transport chain. Balsa E, Marco R, Perales-Clemente E, Szklarczyk R, Calvo E, Landázuri MO, et al. Cell Metab. 2012 Sep 5;16(3):378–86. PubMed Europe PMC Scholia
2. NDUFA4 mutations underlie dysfunction of a cytochrome c oxidase subunit linked to human neurological disease. Pitceathly RDS, Rahman S, Wedatilake Y, Polke JM, Cirak S, Foley AR, et al. Cell Rep. 2013 Jun 27;3(6):1795–805. PubMed Europe PMC Scholia
3. Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes. Signes A, Fernandez-Vizarra E. Essays Biochem. 2018 Jul 20;62(3):255–70. PubMed Europe PMC Scholia