Hypoxia-dependent self-renewal of myoblasts (WP5023)

Mus musculus

Open in new tab Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
Molecular mechanisms involved in self-renewal of satellite cells in hypoxia. Black arrows: activation of the signaling pathway / protein / molecule. Blunt red arrow: inhibition of the signaling pathway / protein / molecule. Round blue arrow: interaction between two pathways.

Authors

Maximilian Saller , Andra Waagmeester , Eric Weitz , Kristina Hanspers , and Egon Willighagen

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

Notch signaling pathway Wnt signaling pathway

Cell Type Ontology

myoblast

Participants

Label Type Compact URI Comment
Hey1 GeneProduct ncbigene:15213
Hes1 GeneProduct ncbigene:15205
Hey2 GeneProduct ncbigene:15214
MYF5 GeneProduct ncbigene:17877
MYH GeneProduct ncbigene:17879
MYOD1 GeneProduct ncbigene:17927
CDKN1A GeneProduct ncbigene:12575
PAX7 GeneProduct ncbigene:18509
MYOG GeneProduct ncbigene:17928
Notch pathway GeneProduct ncbigene:18128
MAPK14 GeneProduct hgnc.symbol:MAPK14
FoxO1 GeneProduct ncbigene:56458
HIF1a GeneProduct ncbigene:15251
HSP90 GeneProduct ensembl:ENSMUSG00000020048

References

  1. Hypoxia inhibits myogenic differentiation through accelerated MyoD degradation. Di Carlo A, De Mori R, Martelli F, Pompilio G, Capogrossi MC, Germani A. J Biol Chem. 2004 Apr 16;279(16):16332–8. PubMed Europe PMC Scholia
  2. Effects of hypoxia on proliferation and differentiation of myoblasts. Li X, Zhu L, Chen X, Fan M. Med Hypotheses. 2007;69(3):629–36. PubMed Europe PMC Scholia
  3. A Foxo/Notch pathway controls myogenic differentiation and fiber type specification. Kitamura T, Kitamura YI, Funahashi Y, Shawber CJ, Castrillon DH, Kollipara R, et al. J Clin Invest. 2007 Sep;117(9):2477–85. PubMed Europe PMC Scholia
  4. Hypoxia converts the myogenic action of insulin-like growth factors into mitogenic action by differentially regulating multiple signaling pathways. Ren H, Accili D, Duan C. Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5857–62. PubMed Europe PMC Scholia
  5. microRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7. Chen JF, Tao Y, Li J, Deng Z, Yan Z, Xiao X, et al. J Cell Biol. 2010 Sep 6;190(5):867–79. PubMed Europe PMC Scholia
  6. miR-206 and -486 induce myoblast differentiation by downregulating Pax7. Dey BK, Gagan J, Dutta A. Mol Cell Biol. 2011 Jan;31(1):203–14. PubMed Europe PMC Scholia
  7. O(2) regulates skeletal muscle progenitor differentiation through phosphatidylinositol 3-kinase/AKT signaling. Majmundar AJ, Skuli N, Mesquita RC, Kim MN, Yodh AG, Nguyen-McCarty M, et al. Mol Cell Biol. 2012 Jan;32(1):36–49. PubMed Europe PMC Scholia
  8. Hypoxia promotes satellite cell self-renewal and enhances the efficiency of myoblast transplantation. Liu W, Wen Y, Bi P, Lai X, Liu XS, Liu X, et al. Development. 2012 Aug;139(16):2857–65. PubMed Europe PMC Scholia
  9. Muscle-specific microRNAs in skeletal muscle development. Horak M, Novak J, Bienertova-Vasku J. Dev Biol. 2016 Feb 1;410(1):1–13. PubMed Europe PMC Scholia
  10. Hypoxia-inducible factor 1α (HIF-1α) is a major determinant in the enhanced function of muscle-derived progenitors from MRL/MpJ mice. Sinha KM, Tseng C, Guo P, Lu A, Pan H, Gao X, et al. FASEB J. 2019 Jul;33(7):8321–34. PubMed Europe PMC Scholia