GDNF signaling (WP5143)

Homo sapiens

Authors

Dr. T. S. Keshava Prasad , Eric Weitz , and Egon Willighagen

Activity

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

signaling pathway

References

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22. Transforming ability of MEN2A-RET requires activation of the phosphatidylinositol 3-kinase/AKT signaling pathway. Segouffin-Cariou C, Billaud M. J Biol Chem. 2000 Feb 4;275(5):3568–76. PubMed Europe PMC Scholia
23. GFRalpha-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival. Tansey MG, Baloh RH, Milbrandt J, Johnson EM Jr. Neuron. 2000 Mar;25(3):611–23. PubMed Europe PMC Scholia
24. RET receptor expression in thyroid follicular epithelial cell-derived tumors. Bunone G, Uggeri M, Mondellini P, Pierotti MA, Bongarzone I. Cancer Res. 2000 Jun 1;60(11):2845–9. PubMed Europe PMC Scholia
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26. Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor. Hayashi H, Ichihara M, Iwashita T, Murakami H, Shimono Y, Kawai K, et al. Oncogene. 2000 Sep 14;19(39):4469–75. PubMed Europe PMC Scholia
27. c-Src is required for glial cell line-derived neurotrophic factor (GDNF) family ligand-mediated neuronal survival via a phosphatidylinositol-3 kinase (PI-3K)-dependent pathway. Encinas M, Tansey MG, Tsui-Pierchala BA, Comella JX, Milbrandt J, Johnson EM Jr. J Neurosci. 2001 Mar 1;21(5):1464–72. PubMed Europe PMC Scholia
28. Activation of BMK1 via tyrosine 1062 in RET by GDNF and MEN2A mutation. Hayashi Y, Iwashita T, Murakamai H, Kato Y, Kawai K, Kurokawa K, et al. Biochem Biophys Res Commun. 2001 Mar 2;281(3):682–9. PubMed Europe PMC Scholia
29. Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction. Kurokawa K, Iwashita T, Murakami H, Hayashi H, Kawai K, Takahashi M. Oncogene. 2001 Apr 12;20(16):1929–38. PubMed Europe PMC Scholia
30. Glial cell-derived neurotrophic factor (GDNF)-induced migration and signal transduction in corneal epithelial cells. You L, Ebner S, Kruse FE. Invest Ophthalmol Vis Sci. 2001 Oct;42(11):2496–504. PubMed Europe PMC Scholia
31. GDNF acutely modulates excitability and A-type K(+) channels in midbrain dopaminergic neurons. Yang F, Feng L, Zheng F, Johnson SW, Du J, Shen L, et al. Nat Neurosci. 2001 Nov;4(11):1071–8. PubMed Europe PMC Scholia
32. Coordinated activation of autophosphorylation sites in the RET receptor tyrosine kinase: importance of tyrosine 1062 for GDNF mediated neuronal differentiation and survival. Coulpier M, Anders J, Ibáñez CF. J Biol Chem. 2002 Jan 18;277(3):1991–9. PubMed Europe PMC Scholia
33. Activation of RET tyrosine kinase regulates interleukin-8 production by multiple signaling pathways. Iwahashi N, Murakami H, Nimura Y, Takahashi M. Biochem Biophys Res Commun. 2002 Jun 14;294(3):642–9. PubMed Europe PMC Scholia
34. Glial cell line-derived neurotrophic factor up-regulates the expression of tyrosine hydroxylase gene in human neuroblastoma cell lines. Xiao H, Hirata Y, Isobe KI, Kiuchi K. J Neurochem. 2002 Aug;82(4):801–8. PubMed Europe PMC Scholia
35. GDNF promotes tubulogenesis of GFRalpha1-expressing MDCK cells by Src-mediated phosphorylation of Met receptor tyrosine kinase. Popsueva A, Poteryaev D, Arighi E, Meng X, Angers-Loustau A, Kaplan D, et al. J Cell Biol. 2003 Apr 14;161(1):119–29. PubMed Europe PMC Scholia
36. The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands. Paratcha G, Ledda F, Ibáñez CF. Cell. 2003 Jun 27;113(7):867–79. PubMed Europe PMC Scholia
37. Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth. Crowder RJ, Enomoto H, Yang M, Johnson EM Jr, Milbrandt J. J Biol Chem. 2004 Oct 1;279(40):42072–81. PubMed Europe PMC Scholia
38. Activation of phosphatidylinositol 3-kinase and extracellular signal-regulated kinase is required for glial cell line-derived neurotrophic factor-induced migration and invasion of pancreatic carcinoma cells. Veit C, Genze F, Menke A, Hoeffert S, Gress TM, Gierschik P, et al. Cancer Res. 2004 Aug 1;64(15):5291–300. PubMed Europe PMC Scholia
39. GDNF-induced leukemia inhibitory factor can mediate differentiation via the MEK/ERK pathway in pheochromocytoma cells derived from nf1-heterozygous knockout mice. Park JI, Powers JF, Tischler AS, Strock CJ, Ball DW, Nelkin BD. Exp Cell Res. 2005 Feb 1;303(1):79–88. PubMed Europe PMC Scholia
40. Enteric neuroblasts require the phosphatidylinositol 3-kinase/Akt/Forkhead pathway for GDNF-stimulated survival. Srinivasan S, Anitha M, Mwangi S, Heuckeroth RO. Mol Cell Neurosci. 2005 May;29(1):107–19. PubMed Europe PMC Scholia
41. Glial cell line-derived neurotrophic factor-induced signaling in Schwann cells. Iwase T, Jung CG, Bae H, Zhang M, Soliven B. J Neurochem. 2005 Sep;94(6):1488–99. PubMed Europe PMC Scholia
42. Differential effects of glial cell line-derived neurotrophic factor and neurturin in RET/GFRalpha1-expressing cells. Lee RHK, Wong WL, Chan CH, Chan SY. J Neurosci Res. 2006 Jan;83(1):80–90. PubMed Europe PMC Scholia
43. Glial cell line-derived neurotrophic factor promotes the arborization of cultured striatal neurons through the p42/p44 mitogen-activated protein kinase pathway. García-Martínez JM, Pérez-Navarro E, Gavaldà N, Alberch J. J Neurosci Res. 2006 Jan;83(1):68–79. PubMed Europe PMC Scholia
44. GDNF family ligands trigger indirect neuroprotective signaling in retinal glial cells. Hauck SM, Kinkl N, Deeg CA, Swiatek-de Lange M, Schöffmann S, Ueffing M. Mol Cell Biol. 2006 Apr;26(7):2746–57. PubMed Europe PMC Scholia
45. Novel role of neuronal Ca2+ sensor-1 as a survival factor up-regulated in injured neurons. Nakamura TY, Jeromin A, Smith G, Kurushima H, Koga H, Nakabeppu Y, et al. J Cell Biol. 2006 Mar 27;172(7):1081–91. PubMed Europe PMC Scholia
46. Interaction of SH2-Bbeta with RET is involved in signaling of GDNF-induced neurite outgrowth. Zhang Y, Zhu W, Wang YG, Liu XJ, Jiao L, Liu X, et al. J Cell Sci. 2006 Apr 15;119(Pt 8):1666–76. PubMed Europe PMC Scholia
47. Dok-4 regulates GDNF-dependent neurite outgrowth through downstream activation of Rap1 and mitogen-activated protein kinase. Uchida M, Enomoto A, Fukuda T, Kurokawa K, Maeda K, Kodama Y, et al. J Cell Sci. 2006 Aug 1;119(Pt 15):3067–77. PubMed Europe PMC Scholia
48. Glial cell line-derived neurotrophic factor-mediated enteric neuronal survival involves glycogen synthase kinase-3beta phosphorylation and coupling with 14-3-3. Mwangi S, Anitha M, Fu H, Sitaraman SV, Srinivasan S. Neuroscience. 2006 Nov 17;143(1):241–51. PubMed Europe PMC Scholia
49. Role of Src family kinases and N-Myc in spermatogonial stem cell proliferation. Braydich-Stolle L, Kostereva N, Dym M, Hofmann MC. Dev Biol. 2007 Apr 1;304(1):34–45. PubMed Europe PMC Scholia
50. The dependence receptor Ret induces apoptosis in somatotrophs through a Pit-1/p53 pathway, preventing tumor growth. Cañibano C, Rodriguez NL, Saez C, Tovar S, Garcia-Lavandeira M, Borrello MG, et al. EMBO J. 2007 Apr 18;26(8):2015–28. PubMed Europe PMC Scholia
51. Sprouty2 regulates growth and differentiation of human neuroblastoma cells through RET tyrosine kinase. Ishida M, Ichihara M, Mii S, Jijiwa M, Asai N, Enomoto A, et al. Cancer Sci. 2007 Jun;98(6):815–21. PubMed Europe PMC Scholia
52. Glial cell line-derived neurotrophic factor and neurturin inhibit neurite outgrowth and activate RhoA through GFR alpha 2b, an alternatively spliced isoform of GFR alpha 2. Yoong LF, Too HP. J Neurosci. 2007 May 23;27(21):5603–14. PubMed Europe PMC Scholia
53. PTEN modulates GDNF/RET mediated chemotaxis and branching morphogenesis in the developing kidney. Kim D, Dressler GR. Dev Biol. 2007 Jul 15;307(2):290–9. PubMed Europe PMC Scholia
54. Gdnf upregulates c-Fos transcription via the Ras/Erk1/2 pathway to promote mouse spermatogonial stem cell proliferation. He Z, Jiang J, Kokkinaki M, Golestaneh N, Hofmann MC, Dym M. Stem Cells. 2008 Jan;26(1):266–78. PubMed Europe PMC Scholia
55. The upregulation of GLAST-1 is an indirect antiapoptotic mechanism of GDNF and neurturin in the adult CNS. Koeberle PD, Bähr M. Cell Death Differ. 2008 Mar;15(3):471–83. PubMed Europe PMC Scholia
56. Lrig1 is an endogenous inhibitor of Ret receptor tyrosine kinase activation, downstream signaling, and biological responses to GDNF. Ledda F, Bieraugel O, Fard SS, Vilar M, Paratcha G. J Neurosci. 2008 Jan 2;28(1):39–49. PubMed Europe PMC Scholia
57. Integrin beta1 is involved in the signaling of glial cell line-derived neurotrophic factor. Cao JP, Yu JK, Li C, Sun Y, Yuan HH, Wang HJ, et al. J Comp Neurol. 2008 Jul 10;509(2):203–10. PubMed Europe PMC Scholia
58. Analysis of Ret knockin mice reveals a critical role for IKKs, but not PI 3-K, in neurotrophic factor-induced survival of sympathetic neurons. Encinas M, Rozen EJ, Dolcet X, Jain S, Comella JX, Milbrandt J, et al. Cell Death Differ. 2008 Sep;15(9):1510–21. PubMed Europe PMC Scholia
59. The involvement of NF-kappaB p65/p52 in the effects of GDNF on DA neurons in early PD rats. Cao JP, Wang HJ, Yu JK, Liu HM, Gao DS. Brain Res Bull. 2008 Jul 30;76(5):505–11. PubMed Europe PMC Scholia
60. Calbindin-D28K expression induced by glial cell line-derived neurotrophic factor in substantia nigra neurons dependent on PI3K/Akt/NF-kappaB signaling pathway. Wang HJ, Cao JP, Yu JK, Zhang LC, Jiang ZJ, Gao DS. Eur J Pharmacol. 2008 Oct 24;595(1–3):7–12. PubMed Europe PMC Scholia
61. CD2AP and Cbl-3/Cbl-c constitute a critical checkpoint in the regulation of ret signal transduction. Tsui CC, Pierchala BA. J Neurosci. 2008 Aug 27;28(35):8789–800. PubMed Europe PMC Scholia
62. Phosphoproteome study reveals Hsp27 as a novel signaling molecule involved in GDNF-induced neurite outgrowth. Hong Z, Zhang QY, Liu J, Wang ZQ, Zhang Y, Xiao Q, et al. J Proteome Res. 2009 Jun;8(6):2768–87. PubMed Europe PMC Scholia
63. Glial cell-derived neurotrophic factor increases migration of human chondrosarcoma cells via ERK and NF-kappaB pathways. Su CM, Lu DY, Hsu CJ, Chen HT, Huang CY, Yang WH, et al. J Cell Physiol. 2009 Aug;220(2):499–507. PubMed Europe PMC Scholia
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65. Transgene-mediated GDNF expression enhances synaptic connectivity and GABA transmission to improve functional outcome after spinal cord contusion. Koelsch A, Feng Y, Fink DJ, Mata M. J Neurochem. 2010 Apr;113(1):143–52. PubMed Europe PMC Scholia
66. Targeting the receptor tyrosine kinase RET sensitizes breast cancer cells to tamoxifen treatment and reveals a role for RET in endocrine resistance. Plaza-Menacho I, Morandi A, Robertson D, Pancholi S, Drury S, Dowsett M, et al. Oncogene. 2010 Aug 19;29(33):4648–57. PubMed Europe PMC Scholia
67. Phosphorylation of protocadherin proteins by the receptor tyrosine kinase Ret. Schalm SS, Ballif BA, Buchanan SM, Phillips GR, Maniatis T. Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13894–9. PubMed Europe PMC Scholia
68. Protein-tyrosine phosphatase SHP2 contributes to GDNF neurotrophic activity through direct binding to phospho-Tyr687 in the RET receptor tyrosine kinase. Perrinjaquet M, Vilar M, Ibáñez CF. J Biol Chem. 2010 Oct 8;285(41):31867–75. PubMed Europe PMC Scholia
69. Rap1GAP interacts with RET and suppresses GDNF-induced neurite outgrowth. Jiao L, Zhang Y, Hu C, Wang YG, Huang A, He C. Cell Res. 2011 Feb;21(2):327–37. PubMed Europe PMC Scholia
70. Nature and duration of growth factor signaling through receptor tyrosine kinases regulates HSV-1 latency in neurons. Camarena V, Kobayashi M, Kim JY, Roehm P, Perez R, Gardner J, et al. Cell Host Microbe. 2010 Oct 21;8(4):320–30. PubMed Europe PMC Scholia
71. GDNF stimulates the proliferation of cultured mouse immature Sertoli cells via its receptor subunit NCAM and ERK1/2 signaling pathway. Yang Y, Han C. BMC Cell Biol. 2010 Oct 18;11:78. PubMed Europe PMC Scholia
72. Loss of Sprouty2 partially rescues renal hypoplasia and stomach hypoganglionosis but not intestinal aganglionosis in Ret Y1062F mutant mice. Miyamoto R, Jijiwa M, Asai M, Kawai K, Ishida-Takagishi M, Mii S, et al. Dev Biol. 2011 Jan 15;349(2):160–8. PubMed Europe PMC Scholia
73. Sphingosine kinase 1/S1P pathway involvement in the GDNF-induced GAP43 transcription. Murakami M, Ito H, Hagiwara K, Kobayashi M, Hoshikawa A, Takagi A, et al. J Cell Biochem. 2011 Nov;112(11):3449–58. PubMed Europe PMC Scholia
74. NANOS2 acts downstream of glial cell line-derived neurotrophic factor signaling to suppress differentiation of spermatogonial stem cells. Sada A, Hasegawa K, Pin PH, Saga Y. Stem Cells. 2012 Feb;30(2):280–91. PubMed Europe PMC Scholia
75. Identification of a key motif that determines the differential surface levels of RET and TrkB tyrosine kinase receptors and controls depolarization enhanced RET surface insertion. Li XZ, Yan J, Huang SH, Zhao L, Wang J, Chen ZY. J Biol Chem. 2012 Jan 13;287(3):1932–45. PubMed Europe PMC Scholia
76. A new alternative NF-κB pathway mediated the neuroprotection of GDNF on 6-OHDA-induced DA neurons neurotoxicity. Sun Y, Huang X, Liu M, Cao J, Chen J, Wang H, et al. Brain Res. 2012 Feb 9;1437:38–49. PubMed Europe PMC Scholia
77. Ret is a multifunctional coreceptor that integrates diffusible- and contact-axon guidance signals. Bonanomi D, Chivatakarn O, Bai G, Abdesselem H, Lettieri K, Marquardt T, et al. Cell. 2012 Feb 3;148(3):568–82. PubMed Europe PMC Scholia
78. GDNF restores human blood-nerve barrier function via RET tyrosine kinase-mediated cytoskeletal reorganization. Yosef N, Ubogu EE. Microvasc Res. 2012 May;83(3):298–310. PubMed Europe PMC Scholia
79. RET PLCγ phosphotyrosine binding domain regulates Ca2+ signaling and neocortical neuronal migration. Lundgren TK, Nakahata K, Fritz N, Rebellato P, Zhang S, Uhlén P. PLoS One. 2012;7(2):e31258. PubMed Europe PMC Scholia
80. Control of Aβ release from human neurons by differentiation status and RET signaling. Scholz D, Chernyshova Y, Leist M. Neurobiol Aging. 2013 Jan;34(1):184–99. PubMed Europe PMC Scholia
81. Involvement of N-cadherin in the protective effect of glial cell line-derived neurotrophic factor on dopaminergic neuron damage. Zuo T, Qin JY, Chen J, Shi Z, Liu M, Gao X, et al. Int J Mol Med. 2013 Mar;31(3):561–8. PubMed Europe PMC Scholia
82. SorLA controls neurotrophic activity by sorting of GDNF and its receptors GFRα1 and RET. Glerup S, Lume M, Olsen D, Nyengaard JR, Vaegter CB, Gustafsen C, et al. Cell Rep. 2013 Jan 31;3(1):186–99. PubMed Europe PMC Scholia
83. NF-κB p65/p52 plays a role in GDNF up-regulating Bcl-2 and Bcl-w expression in 6-OHDA-induced apoptosis of MN9D cell. Cao JP, Niu HY, Wang HJ, Huang XG, Gao DS. Int J Neurosci. 2013 Oct;123(10):705–10. PubMed Europe PMC Scholia
84. GDNF-RET signaling in ER-positive breast cancers is a key determinant of response and resistance to aromatase inhibitors. Morandi A, Martin LA, Gao Q, Pancholi S, Mackay A, Robertson D, et al. Cancer Res. 2013 Jun 15;73(12):3783–95. PubMed Europe PMC Scholia
85. Concerted interaction of TGF-β and GDNF mediates neuronal differentiation. Zajzon K, Pröls F, Heermann S. Neuroreport. 2013 Sep 11;24(13):704–11. PubMed Europe PMC Scholia
86. GDNF signaling levels control migration and neuronal differentiation of enteric ganglion precursors. Uesaka T, Nagashimada M, Enomoto H. J Neurosci. 2013 Oct 9;33(41):16372–82. PubMed Europe PMC Scholia
87. GDNF increases cell motility in human colon cancer through VEGF-VEGFR1 interaction. Huang SM, Chen TS, Chiu CM, Chang LK, Liao KF, Tan HM, et al. Endocr Relat Cancer. 2013 Dec 20;21(1):73–84. PubMed Europe PMC Scholia
88. CD2-associated protein (CD2AP) enhances casitas B lineage lymphoma-3/c (Cbl-3/c)-mediated Ret isoform-specific ubiquitination and degradation via its amino-terminal Src homology 3 domains. Calco GN, Stephens OR, Donahue LM, Tsui CC, Pierchala BA. J Biol Chem. 2014 Mar 14;289(11):7307–19. PubMed Europe PMC Scholia
89. Glial cell line-derived neurotrophic factor protects against high-fat diet-induced obesity. Mwangi SM, Nezami BG, Obukwelu B, Anitha M, Marri S, Fu P, et al. Am J Physiol Gastrointest Liver Physiol. 2014 Mar;306(6):G515-25. PubMed Europe PMC Scholia
90. GM1 ganglioside enhances Ret signaling in striatum. Newburn EN, Duchemin AM, Neff NH, Hadjiconstantinou M. J Neurochem. 2014 Aug;130(4):541–54. PubMed Europe PMC Scholia
91. Selective inhibition of RET mediated cell proliferation in vitro by the kinase inhibitor SPP86. Alao JP, Michlikova S, Dinér P, Grøtli M, Sunnerhagen P. BMC Cancer. 2014 Nov 20;14:853. PubMed Europe PMC Scholia
92. Functional differences between GDNF-dependent and FGF2-dependent mouse spermatogonial stem cell self-renewal. Takashima S, Kanatsu-Shinohara M, Tanaka T, Morimoto H, Inoue K, Ogonuki N, et al. Stem Cell Reports. 2015 Mar 10;4(3):489–502. PubMed Europe PMC Scholia
93. Identification of a Vav2-dependent mechanism for GDNF/Ret control of mesolimbic DAT trafficking. Zhu S, Zhao C, Wu Y, Yang Q, Shao A, Wang T, et al. Nat Neurosci. 2015 Aug;18(8):1084–93. PubMed Europe PMC Scholia
94. Distinct Temporal Regulation of RET Isoform Internalization: Roles of Clathrin and AP2. Crupi MJF, Yoganathan P, Bone LN, Lian E, Fetz A, Antonescu CN, et al. Traffic. 2015 Nov;16(11):1155–73. PubMed Europe PMC Scholia
95. Glial cell line-derived neurotrophic factor protects against high-fat diet-induced hepatic steatosis by suppressing hepatic PPAR-γ expression. Mwangi SM, Peng S, Nezami BG, Thorn N, Farris AB 3rd, Jain S, et al. Am J Physiol Gastrointest Liver Physiol. 2016 Jan 15;310(2):G103-16. PubMed Europe PMC Scholia
96. Smoothened-independent activation of hedgehog signaling by rearranged during transfection promotes neuroblastoma cell proliferation and tumor growth. Ruan H, Luo H, Wang J, Ji X, Zhang Z, Wu J, et al. Biochim Biophys Acta. 2016 Sep;1860(9):1961–72. PubMed Europe PMC Scholia
97. GDNF From Human Periodontal Ligament Cells Treated With Pro-Inflammatory Cytokines Promotes Neurocytic Differentiation of PC12 Cells. Yoshida S, Yamamoto N, Wada N, Tomokiyo A, Hasegawa D, Hamano S, et al. J Cell Biochem. 2017 Apr;118(4):699–708. PubMed Europe PMC Scholia
98. The Glial Cell-Derived Neurotrophic Factor (GDNF)-responsive Phosphoprotein Landscape Identifies Raptor Phosphorylation Required for Spermatogonial Progenitor Cell Proliferation. Wang M, Guo Y, Wang M, Zhou T, Xue Y, Du G, et al. Mol Cell Proteomics. 2017 Jun;16(6):982–97. PubMed Europe PMC Scholia
99. Glial cell-derived neurotrophic factor promotes dental pulp stem cell migration. Xiao N, Yu WY, Liu D. J Tissue Eng Regen Med. 2018 Mar;12(3):705–14. PubMed Europe PMC Scholia
100. Reciprocal feedback regulation of ST3GAL1 and GFRA1 signaling in breast cancer cells. Fan TC, Yeo HL, Hsu HM, Yu JC, Ho MY, Lin WD, et al. Cancer Lett. 2018 Oct 10;434:184–95. PubMed Europe PMC Scholia
101. Glial Cell Line-Derived Neurotrophic Factor (GDNF) Promotes Angiogenesis through the Demethylation of the Fibromodulin (FMOD) Promoter in Glioblastoma. Chen M, Ba H, Lu C, Dai J, Sun J. Med Sci Monit. 2018 Sep 3;24:6137–43. PubMed Europe PMC Scholia
102. The laminin binding α3 and α6 integrins cooperate to promote epithelial cell adhesion and growth. Yazlovitskaya EM, Viquez OM, Tu T, De Arcangelis A, Georges-Labouesse E, Sonnenberg A, et al. Matrix Biol. 2019 Apr;77:101–16. PubMed Europe PMC Scholia
103. FAT4 Fine-Tunes Kidney Development by Regulating RET Signaling. Zhang H, Bagherie-Lachidan M, Badouel C, Enderle L, Peidis P, Bremner R, et al. Dev Cell. 2019 Mar 25;48(6):780-792.e4. PubMed Europe PMC Scholia
104. AKT3 Is a Pivotal Molecule of Cadherin-22 and GDNF Family Receptor-α1 Signal Pathways Regulating Self-Renewal in Female Germline Stem Cells. Zhang X, Wei R, Sun Y, Xia Q, Xie W, Song H, et al. Stem Cells. 2019 Aug;37(8):1095–107. PubMed Europe PMC Scholia
105. Glial cell line-derived neurotrophic factor (GDNF) mediates hepatic stellate cell activation via ALK5/Smad signalling. Tao L, Ma W, Wu L, Xu M, Yang Y, Zhang W, et al. Gut. 2019 Dec;68(12):2214–27. PubMed Europe PMC Scholia
106. Neurotrophic factor GDNF regulates intestinal barrier function in inflammatory bowel disease. Meir M, Burkard N, Ungewiß H, Diefenbacher M, Flemming S, Kannapin F, et al. J Clin Invest. 2019 Jun 17;129(7):2824–40. PubMed Europe PMC Scholia
107. RET isoform-specific interaction with scaffold protein Ezrin promotes cell migration and chemotaxis in lung adenocarcinoma. Moodley S, Lian EY, Crupi MJF, Hyndman BD, Mulligan LM. Lung Cancer. 2020 Apr;142:123–31. PubMed Europe PMC Scholia