MAPK signaling pathway (WP510)

Saccharomyces cerevisiae

The MAPK/ERK pathway is a signal transduction pathway that couples intracellular responses to the binding of growth factors to cell surface receptors. In many cell types, activation of this pathway promotes cell division. Adapted from: http://www.genome.ad.jp/dbget-bin/get_pathway?org_name=sce&mapno=04010

Authors

Nathan Salomonis , Bruce Conklin , Ron Shigeta , Thomas Kelder , Michiel Adriaens , Daniela Digles , Egon Willighagen , Nuno , Kristina Hanspers , Alex Pico , Finterly Hu , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Saccharomyces cerevisiae

Communities

Annotations

Pathway Ontology

mitogen activated protein kinase signaling pathway

Participants

Label Type Compact URI Comment
GTP Metabolite cas:2564-35-4
GDP Metabolite cas:146-91-8
Ste4 GeneProduct sgd:S000005738
Ste1 GeneProduct sgd:S000001126
Mlp1 GeneProduct sgd:S000001803
Msg5 GeneProduct sgd:S000004998
Wsc1,2,3 GeneProduct sgd:S000005534
Ste7 GeneProduct sgd:S000002318
Ssk2 GeneProduct sgd:S000005314
Ras2 GeneProduct sgd:S000005042
Ste11 GeneProduct sgd:S000004354
Hog1 GeneProduct sgd:S000004103
Cdc42 GeneProduct sgd:S000004219
Sho1 GeneProduct sgd:S000000920
Ctt1 GeneProduct sgd:S000003320
Swi4 GeneProduct sgd:S000000913
Rho1 GeneProduct sgd:S000006369
Ste5 scaffold GeneProduct sgd:S000002510
Mkk1 GeneProduct sgd:S000005757
Ste20 GeneProduct sgd:S000000999
Fus1 GeneProduct sgd:S000000532
Ssk1 GeneProduct sgd:S000003996
Kss1 GeneProduct sgd:S000003272
Mid2 GeneProduct sgd:S000004324
Pkc1 GeneProduct sgd:S000000201
MATalpha GeneProduct sgd:S000006108
Cdc24 GeneProduct sgd:S000000039
Ste2 GeneProduct sgd:S000001868
Mcm1 GeneProduct sgd:S000004646
Fks2 GeneProduct sgd:S000003264
Bkc1 GeneProduct sgd:S000003631
Msn2 GeneProduct sgd:S000004640
Fks1 GeneProduct sgd:S000004334
Pbs2 GeneProduct sgd:S000003664
Dig1 GeneProduct sgd:S000005970
Sln1 GeneProduct sgd:S000001409
Ste12 GeneProduct sgd:S000001126
Ypd1 GeneProduct sgd:S000002394
Tec1 GeneProduct sgd:S000000287
Ste18 GeneProduct sgd:S000003846
Bem1 GeneProduct sgd:S000000404
Ste3 GeneProduct sgd:S000001661
Glo1 GeneProduct sgd:S000004463
GPA1 GeneProduct sgd:S000001047
Dig1,2 GeneProduct sgd:S000005970
MATa GeneProduct sgd:S000002869
Rlm1 GeneProduct sgd:S000006010
Bni1 GeneProduct sgd:S000005215
Slt2 GeneProduct sgd:S000001072
Far1 GeneProduct sgd:S000003693

References

  1. Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae. Chen RE, Thorner J. Biochim Biophys Acta. 2007 Aug;1773(8):1311–40. PubMed Europe PMC Scholia