Network map of SARS-CoV-2 signaling (WP5115)

Homo sapiens

Authors

Dr. T. S. Keshava Prasad , Friederike Ehrhart , Eric Weitz , Egon Willighagen , Susan Coort , Martijn Van De Garde , John Figueira Hasbun , Lars Willighagen , Hiromasa Ono , and Aishwarya Iyer

Activity

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Cited In

• Identifying Drug-Induced Liver Injury Associated With Inflammation-Drug and Drug-Drug Interactions in Pharmacologic Treatments for COVID-19 by Bioinformatics and System Biology Analyses: The Role of Pregnane X Receptor (2022).
• SARS-CoV-2 signaling pathway map: A functional landscape of molecular mechanisms in COVID-19 (2021).
• SARS-CoV-2 induces “cytokine storm” hyperinflammatory responses in RA patients through pyroptosis (2022).
• Single-cell ‘omic profiles of human aortic endothelial cells in vitro and human atherosclerotic lesions ex vivo reveal heterogeneity of endothelial subtype and response to activating perturbations (2024).
• Investigation of the relationship between COVID-19 and pancreatic cancer using bioinformatics and systems biology approaches (2024).
• Autistic spectrum disorder (ASD) - Gene, molecular and pathway signatures linking systemic inflammation, mitochondrial dysfunction, transsynaptic signalling, and neurodevelopmen (2023).

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Organisms

Homo sapiens

Communities

COVID-19

Annotations

Pathway Ontology

disease pathway respiratory system disease pathway

Disease Ontology

severe acute respiratory syndrome

References

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2. ACE2 and TMPRSS2 are expressed on the human ocular surface, suggesting susceptibility to SARS-CoV-2 infection [Internet]. Zhou L, Xu Z, Castiglione GM, Soiberman US, Eberhart CG, Duh EJ. Cold Spring Harbor Laboratory; 2020. Available from: http://dx.doi.org/10.1101/2020.05.09.086165 DOI Scholia
3. Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Yan R, Zhang Y, Li Y, Xia L, Guo Y, Zhou Q. Science. 2020 Mar 27;367(6485):1444–8. PubMed Europe PMC Scholia
4. Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Xiong Y, Liu Y, Cao L, Wang D, Guo M, Jiang A, et al. Emerg Microbes Infect. 2020 Dec;9(1):761–70. PubMed Europe PMC Scholia
5. Downregulated Gene Expression Spectrum and Immune Responses Changed During the Disease Progression in Patients With COVID-19. Ouyang Y, Yin J, Wang W, Shi H, Shi Y, Xu B, et al. Clin Infect Dis. 2020 Nov 19;71(16):2052–60. PubMed Europe PMC Scholia
6. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, et al. Nature. 2020 Jul;583(7816):459–68. PubMed Europe PMC Scholia
7. Cell entry mechanisms of SARS-CoV-2. Shang J, Wan Y, Luo C, Ye G, Geng Q, Auerbach A, et al. Proc Natl Acad Sci U S A. 2020 May 26;117(21):11727–34. PubMed Europe PMC Scholia
8. Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19. Blanco-Melo D, Nilsson-Payant BE, Liu WC, Uhl S, Hoagland D, Møller R, et al. Cell. 2020 May 28;181(5):1036-1045.e9. PubMed Europe PMC Scholia
9. Proteomic and Metabolomic Characterization of COVID-19 Patient Sera. Shen B, Yi X, Sun Y, Bi X, Du J, Zhang C, et al. Cell. 2020 Jul 9;182(1):59-72.e15. PubMed Europe PMC Scholia
10. Upper airway gene expression differentiates COVID-19 from other acute respiratory illnesses and reveals suppression of innate immune responses by SARS-CoV-2. Mick E, Kamm J, Pisco AO, Ratnasiri K, Babik JM, Calfee CS, et al. medRxiv. 2020 May 19;2020.05.18.20105171. PubMed Europe PMC Scholia
11. The ORF3a protein of SARS-CoV-2 induces apoptosis in cells. Ren Y, Shu T, Wu D, Mu J, Wang C, Huang M, et al. Cell Mol Immunol. 2020 Aug;17(8):881–3. PubMed Europe PMC Scholia
12. Platelet gene expression and function in patients with COVID-19. Manne BK, Denorme F, Middleton EA, Portier I, Rowley JW, Stubben C, et al. Blood. 2020 Sep 10;136(11):1317–29. PubMed Europe PMC Scholia
13. Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection. Messner CB, Demichev V, Wendisch D, Michalick L, White M, Freiwald A, et al. Cell Syst. 2020 Jul 22;11(1):11-24.e4. PubMed Europe PMC Scholia
14. Dysregulation in Akt/mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells. Appelberg S, Gupta S, Svensson Akusjärvi S, Ambikan AT, Mikaeloff F, Saccon E, et al. Emerg Microbes Infect. 2020 Dec;9(1):1748–60. PubMed Europe PMC Scholia
15. Activation and evasion of type I interferon responses by SARS-CoV-2. Lei X, Dong X, Ma R, Wang W, Xiao X, Tian Z, et al. Nat Commun. 2020 Jul 30;11(1):3810. PubMed Europe PMC Scholia
16. Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis. Li J, Guo M, Tian X, Wang X, Yang X, Wu P, et al. Med (N Y). 2021 Jan 15;2(1):99-112.e7. PubMed Europe PMC Scholia
17. Evasion of Type I Interferon by SARS-CoV-2. Xia H, Cao Z, Xie X, Zhang X, Chen JYC, Wang H, et al. Cell Rep. 2020 Oct 6;33(1):108234. PubMed Europe PMC Scholia
18. ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation. Miao G, Zhao H, Li Y, Ji M, Chen Y, Shi Y, et al. Dev Cell. 2021 Feb 22;56(4):427-442.e5. PubMed Europe PMC Scholia
19. Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Stukalov A, Girault V, Grass V, Karayel O, Bergant V, Urban C, et al. Nature. 2021 Jun;594(7862):246–52. PubMed Europe PMC Scholia