Mevalonate pathway (WP3963)
Homo sapiens
The mevalonate pathway, also known as the isoprenoid pathway or HMG-CoA reductase pathway is an essential metabolic pathway present in eukaryotes, archaea, and some bacteria. The pathway produces two five-carbon building blocks called isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP), which are used to make isoprenoids, a diverse class of over 30,000 biomolecules such as cholesterol, vitamin K, coenzyme Q10, and all steroid hormones. (Wikipedia)
For a description of pathway objects, see the WikiPathways Legend.
Authors
Kristina Hanspers , Jacob Windsor , Martina Summer-Kutmon , Egon Willighagen , and Alex PicoActivity
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Cited In
- MicroRNA-874 targets phosphomevalonate kinase and inhibits cancer cell growth via the mevalonate pathway (2022).
- Glypican-3 regulated epithelial mesenchymal transformation-related genes in osteosarcoma: based on comprehensive tumor microenvironment profiling (2025).
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Organisms
Homo sapiensCommunities
ONTOXAnnotations
Pathway Ontology
isoprenoid metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| (R)-5-diphosphomevalonate | Metabolite | chebi:15899 | |
| Dimethylallyl diphosphate | Metabolite | chebi:16057 | |
| Acetyl-CoA | Metabolite | chebi:15351 | |
| Dolichol | Metabolite | chebi:88766 | |
| Ubiquinone | Metabolite | chebi:16389 | |
| Geranyl diphosphate | Metabolite | chebi:17211 | |
| Acetoacetyl-CoA | Metabolite | chebi:15345 | |
| (R)-5-phosphomevalonate | Metabolite | chebi:17436 | |
| HMG-CoA | Metabolite | chebi:15467 | |
| mevalonate | Metabolite | wikidata:Q27109878 | |
| Cholesterol | Metabolite | hmdb:HMDB0000067 | |
| ACAT2 | GeneProduct | ensembl:ENSG00000120437 | |
| PMVK | GeneProduct | ensembl:ENSG00000163344 | |
| MVD | GeneProduct | ensembl:ENSG00000167508 | |
| HMGCS1 | GeneProduct | ensembl:ENSG00000112972 | |
| MVK | GeneProduct | ensembl:ENSG00000110921 | |
| FDPS | GeneProduct | ensembl:ENSG00000160752 | |
| HMGCR | GeneProduct | ensembl:ENSG00000113161 |
References
- The interplay between cell signalling and the mevalonate pathway in cancer. Mullen PJ, Yu R, Longo J, Archer MC, Penn LZ. Nat Rev Cancer. 2016 Nov;16(11):718–31. PubMed Europe PMC Scholia