Cell lineage map for neuronal differentiation (WP5417)

Homo sapiens

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This cell lineage map consists of a set of cell types emerging during neural differentiation. A selection of cell type-specific markers was made based on literature (e.g. Beccari et al., 2018, https://doi.org/10.1038/s41586-018-0578-0; Kügler et al., 2010, https://doi.org/10.14573/altex.2010.1.16; Spangler et al., 2018, https://doi.org/10.1016/j.scr.2018.07.022; Tao and Zhang, 2016, https://doi.org/10.1016/j.stem.2016.10.015) to distinguish these different cell types. This map was published in: Victoria de Leeuw et al., 2020, NeuroToxicology 76, 1-9. https://doi.org/10.1016/j.neuro.2019.09.014.

Authors

Jeroen Pennings , Egon Willighagen , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Cell Type Ontology

neuron mesodermal cell neural crest cell ectodermal cell noradrenergic neuron cholinergic neuron stem cell astrocyte dopaminergic neuron endodermal cell glutamatergic neuron GABAergic neuron oligodendrocyte neural progenitor cell serotonergic neuron

Pathway Ontology

regulatory pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
DPPA3 GeneProduct ensembl:ENSG00000187569
POU5F1 GeneProduct ensembl:ENSG00000204531
SOX2 GeneProduct ensembl:ENSG00000181449
ZFP42 GeneProduct ensembl:ENSG00000179059
HES1 GeneProduct ensembl:ENSG00000114315
NOTCH1 GeneProduct ensembl:ENSG00000148400
PECAM1 GeneProduct ensembl:ENSG00000261371
TBXT GeneProduct ensembl:ENSG00000164458
TPM1 GeneProduct ensembl:ENSG00000140416
TNC GeneProduct ensembl:ENSG00000041982
ITGB1 GeneProduct ensembl:ENSG00000150093
KRT15 GeneProduct ensembl:ENSG00000171346
ITGA6 GeneProduct ensembl:ENSG00000091409
MSX2 GeneProduct ensembl:ENSG00000120149
NGFR GeneProduct ensembl:ENSG00000064300
PAX3 GeneProduct ensembl:ENSG00000135903
ROBO1 GeneProduct ensembl:ENSG00000169855
SOX10 GeneProduct ensembl:ENSG00000100146
SOX9 GeneProduct ensembl:ENSG00000125398
TWIST1 GeneProduct ensembl:ENSG00000122691
TWIST2 GeneProduct ensembl:ENSG00000233608
SNAI1 GeneProduct ensembl:ENSG00000124216
SNAI2 GeneProduct ensembl:ENSG00000019549
SLC1A2 GeneProduct ensembl:ENSG00000110436
SLC1A3 GeneProduct ensembl:ENSG00000079215
S100B GeneProduct ensembl:ENSG00000160307
CSPG4 GeneProduct ensembl:ENSG00000173546
MBP GeneProduct ensembl:ENSG00000197971
MOG GeneProduct ensembl:ENSG00000204655
OLIG2 GeneProduct ensembl:ENSG00000205927
LIN7A GeneProduct ensembl:ENSG00000111052
RIMS2 GeneProduct ensembl:ENSG00000176406
SYP GeneProduct ensembl:ENSG00000102003
DLG4 GeneProduct ensembl:ENSG00000132535
HOMER2 GeneProduct ensembl:ENSG00000103942
SLC17A6 GeneProduct ensembl:ENSG00000091664
SLC6A1 GeneProduct ensembl:ENSG00000157103
GAD1 GeneProduct ensembl:ENSG00000128683
GAD2 GeneProduct ensembl:ENSG00000136750
GLRB GeneProduct ensembl:ENSG00000109738
SLC6A5 GeneProduct ensembl:ENSG00000165970
SLC18A3 GeneProduct ensembl:ENSG00000187714
TH GeneProduct ensembl:ENSG00000180176
SLC6A3 GeneProduct ensembl:ENSG00000142319
SLC6A2 GeneProduct ensembl:ENSG00000103546
ADRA2B GeneProduct ensembl:ENSG00000274286
TPH1 GeneProduct ensembl:ENSG00000129167
SLC6A4 GeneProduct ensembl:ENSG00000108576
CLDN11 GeneProduct ensembl:ENSG00000013297
GPHN GeneProduct ensembl:ENSG00000171723
CHAT GeneProduct ensembl:ENSG00000070748
SHANK3 GeneProduct ensembl:ENSG00000251322
GRIN2B GeneProduct ensembl:ENSG00000273079
ACHE GeneProduct ensembl:ENSG00000087085
SNAP25 GeneProduct ensembl:ENSG00000132639
NODAL GeneProduct ensembl:ENSG00000156574
ALDH1L1 GeneProduct ensembl:ENSG00000144908
GLRA2 GeneProduct ensembl:ENSG00000101958
NANOG GeneProduct ensembl:ENSG00000111704
HTR1A GeneProduct ensembl:ENSG00000178394
RBFOX3 GeneProduct ensembl:ENSG00000167281
SOX17 GeneProduct ensembl:ENSG00000164736
GABBR1 GeneProduct ensembl:ENSG00000204681
MIXL1 GeneProduct ensembl:ENSG00000185155
ERAS GeneProduct ensembl:ENSG00000187682
KCNJ6 GeneProduct ensembl:ENSG00000157542
ESRRB GeneProduct ensembl:ENSG00000119715
CASK GeneProduct ensembl:ENSG00000147044
PCLO GeneProduct ensembl:ENSG00000186472
ADRA2C GeneProduct ensembl:ENSG00000184160
NES GeneProduct ensembl:ENSG00000132688
LEF1 GeneProduct ensembl:ENSG00000138795
PPFIA1 GeneProduct ensembl:ENSG00000131626
FABP7 GeneProduct ensembl:ENSG00000164434
HOMER3 GeneProduct ensembl:ENSG00000051128
NLGN1 GeneProduct ensembl:ENSG00000169760
ERC1 GeneProduct ensembl:ENSG00000082805
UNC13A GeneProduct ensembl:ENSG00000130477
FOXA2 GeneProduct ensembl:ENSG00000125798
LMX1B GeneProduct ensembl:ENSG00000136944
NEFL GeneProduct ensembl:ENSG00000277586
GFAP GeneProduct ensembl:ENSG00000131095
HOMER1 GeneProduct ensembl:ENSG00000152413
GATA4 GeneProduct ensembl:ENSG00000136574
GRIN1 GeneProduct ensembl:ENSG00000176884
NEFM GeneProduct ensembl:ENSG00000104722
NR4A2 GeneProduct ensembl:ENSG00000153234
GLS GeneProduct ensembl:ENSG00000115419
GLRA4 GeneProduct ensembl:ENSG00000188828
PAX6 GeneProduct ensembl:ENSG00000007372
KLF4 GeneProduct ensembl:ENSG00000136826
AP2A2 GeneProduct ensembl:ENSG00000183020
BSN GeneProduct ensembl:ENSG00000164061
CDH2 GeneProduct ensembl:ENSG00000170558
HNF4A GeneProduct ensembl:ENSG00000101076
LHX1 GeneProduct ensembl:ENSG00000273706
FEV GeneProduct ensembl:ENSG00000163497
CNP GeneProduct ensembl:ENSG00000173786
GLRA3 GeneProduct ensembl:ENSG00000145451
DLL1 GeneProduct ensembl:ENSG00000198719
EVX1 GeneProduct ensembl:ENSG00000106038
AQP4 GeneProduct ensembl:ENSG00000171885
SHANK1 GeneProduct ensembl:ENSG00000161681
AP2A1 GeneProduct ensembl:ENSG00000196961
GLRA1 GeneProduct ensembl:ENSG00000145888
DLG3 GeneProduct ensembl:ENSG00000082458
HES5 GeneProduct ensembl:ENSG00000197921
CACNG2 GeneProduct ensembl:ENSG00000166862
DCX GeneProduct ensembl:ENSG00000077279
CDH1 GeneProduct ensembl:ENSG00000039068
SLC17A7 GeneProduct ensembl:ENSG00000104888
CD24 GeneProduct ensembl:ENSG00000272398
SLC6A9 GeneProduct ensembl:ENSG00000196517
MSX1 GeneProduct ensembl:ENSG00000163132
FOXD3 GeneProduct ensembl:ENSG00000187140
DLG2 GeneProduct ensembl:ENSG00000150672
GABBR2 GeneProduct ensembl:ENSG00000136928
FBXO15 GeneProduct ensembl:ENSG00000141665
GLUL GeneProduct ensembl:ENSG00000135821
TBR1 GeneProduct ensembl:ENSG00000136535
RIMBP2 GeneProduct ensembl:ENSG00000060709
BMP4 GeneProduct ensembl:ENSG00000125378
HES3 GeneProduct ensembl:ENSG00000173673
DPPA2 GeneProduct ensembl:ENSG00000163530
HTR5A GeneProduct ensembl:ENSG00000157219
TUBB3 GeneProduct ensembl:ENSG00000258947
DLG1 GeneProduct ensembl:ENSG00000075711
MAP2 GeneProduct ensembl:ENSG00000078018
FGF4 GeneProduct ensembl:ENSG00000075388
GATA6 GeneProduct ensembl:ENSG00000141448
CD34 GeneProduct ensembl:ENSG00000174059
FUT4 GeneProduct ensembl:ENSG00000196371
ADRA2A GeneProduct ensembl:ENSG00000150594

References

  1. Differential effects of fluoxetine and venlafaxine in the neural embryonic stem cell test (ESTn) revealed by a cell lineage map. de Leeuw VC, Hessel EVS, Pennings JLA, Hodemaekers HM, Wackers PFK, van Oostrom CTM, et al. NeuroToxicology [Internet]. 2020 Jan;76:1–9. Available from: http://dx.doi.org/10.1016/j.neuro.2019.09.014 DOI Scholia
  2. A single cell transcriptional portrait of embryoid body differentiation and comparison to progenitors of the developing embryo. Spangler A, Su EY, Craft AM, Cahan P. Stem Cell Research [Internet]. 2018 Aug;31:201–15. Available from: http://dx.doi.org/10.1016/j.scr.2018.07.022 DOI Scholia
  3. Neural Subtype Specification from Human Pluripotent Stem Cells. Tao Y, Zhang SC. Cell Stem Cell [Internet]. 2016 Nov;19(5):573–86. Available from: http://dx.doi.org/10.1016/j.stem.2016.10.015 DOI Scholia
  4. Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids. Beccari L, Moris N, Girgin M, Turner DA, Baillie-Johnson P, Cossy AC, et al. Nature [Internet]. 2018 Oct;562(7726):272–6. Available from: http://dx.doi.org/10.1038/s41586-018-0578-0 DOI Scholia
  5. Markers of murine embryonic and neural stem cells, neurons and astrocytes: reference points for developmental neurotoxicity testing. Kuegler P. ALTEX [Internet]. 2010;16–41. Available from: http://dx.doi.org/10.14573/altex.2010.1.16 DOI Scholia