Nod-like receptor (NLR) signaling pathway (WP1032)

Bos taurus

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Mammalian cells have evolved a set of specialized pattern recognition-molecules (PRMs) to detect conserved molecular motifs present on pathogens known as pathogen associated-molecular-patterns (PAMPs). NLR proteins (alternatively named NBD-LRR or CATERPILLER) represent one subclass of PRMs that have recently attracted much attention. Their cytoplasmic location differs from the classical PRMs which are mostly membrane spanning receptors (such as the Toll-like-receptors (TLRs) or lectins) and accordingly NLRs were proposed to be activated mainly by intracellular bacterial pathogens.

Authors

Alex Pico , Martina Summer-Kutmon , and Eric Weitz

Activity

last edited

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

NOD-like receptor signaling pathway

Participants

Label Type Compact URI Comment
MAP3K7 GeneProduct ensembl:ENSBTAG00000002625 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6885
ERBB2IP GeneProduct ensembl:ENSBTAG00000000415 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55914
EPHB2 GeneProduct ensembl:ENSBTAG00000045902 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2048
MAPK8 GeneProduct ensembl:ENSBTAG00000007876 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5599
IKBKG GeneProduct ensembl:ENSBTAG00000006268 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8517
CHUK GeneProduct ensembl:ENSBTAG00000007591 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1147
IKBKB GeneProduct ensembl:ENSBTAG00000007599 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3551
RELA GeneProduct ensembl:ENSBTAG00000013895 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5970
CD40 GeneProduct ensembl:ENSBTAG00000020736 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:958

References

  1. Intracellular pattern recognition receptors in the host response. Meylan E, Tschopp J, Karin M. Nature. 2006 Jul 6;442(7098):39–44. PubMed Europe PMC Scholia
  2. Nod-like proteins in immunity, inflammation and disease. Fritz JH, Ferrero RL, Philpott DJ, Girardin SE. Nat Immunol. 2006 Dec;7(12):1250–7. PubMed Europe PMC Scholia
  3. Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation. Mariathasan S, Monack DM. Nat Rev Immunol. 2007 Jan;7(1):31–40. PubMed Europe PMC Scholia
  4. Nod-like proteins in inflammation and disease. Carneiro LAM, Magalhaes JG, Tattoli I, Philpott DJ, Travassos LH. J Pathol. 2008 Jan;214(2):136–48. PubMed Europe PMC Scholia
  5. Signal transduction pathways used by NLR-type innate immune receptors. Kufer TA. Mol Biosyst. 2008 May;4(5):380–6. PubMed Europe PMC Scholia
  6. NOD-like receptors (NLRs): bona fide intracellular microbial sensors. Shaw MH, Reimer T, Kim YG, Nuñez G. Curr Opin Immunol. 2008 Aug;20(4):377–82. PubMed Europe PMC Scholia