IL26 signaling (WP5347)

Homo sapiens

Authors

Rex D A B , Egon Willighagen , Kristina Hanspers , Alex Pico , and Eric Weitz

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

signaling pathway interleukin-6 signaling pathway

References

1. The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains. Hör S, Pirzer H, Dumoutier L, Bauer F, Wittmann S, Sticht H, et al. J Biol Chem. 2004 Aug 6;279(32):33343–51. PubMed Europe PMC Scholia
2. The role of the novel Th17 cytokine IL-26 in intestinal inflammation. Dambacher J, Beigel F, Zitzmann K, De Toni EN, Göke B, Diepolder HM, et al. Gut. 2009 Sep;58(9):1207–17. PubMed Europe PMC Scholia
3. Interleukin-26 in antibacterial host defense of human lungs. Effects on neutrophil mobilization. Che KF, Tengvall S, Levänen B, Silverpil E, Smith ME, Awad M, et al. Am J Respir Crit Care Med. 2014 Nov 1;190(9):1022–31. PubMed Europe PMC Scholia
4. Expression of Interleukin-26 is upregulated in inflammatory bowel disease. Fujii M, Nishida A, Imaeda H, Ohno M, Nishino K, Sakai S, et al. World J Gastroenterol. 2017 Aug 14;23(30):5519–29. PubMed Europe PMC Scholia
5. Recombinant human IL-26 facilitates the innate immune response to endotoxin in the bronchoalveolar space of mice in vivo. Bao A, Che KF, Bozinovski S, Ji J, Gregory JA, Kumlien Georén S, et al. PLoS One. 2017 Dec 5;12(12):e0188909. PubMed Europe PMC Scholia
6. Increased IL-26 Expression Promotes T Helper Type 17- and T Helper Type 2-Associated Cytokine Production by Keratinocytes in Atopic Dermatitis. Kamijo H, Miyagaki T, Hayashi Y, Akatsuka T, Watanabe-Otobe S, Oka T, et al. J Invest Dermatol. 2020 Mar;140(3):636-644.e2. PubMed Europe PMC Scholia
7. Promotion of osteoclastogenesis by IL-26 in rheumatoid arthritis. Lee KA, Kim KW, Kim BM, Won JY, Min HK, Lee DW, et al. Arthritis Res Ther. 2019 Dec 12;21(1):283. PubMed Europe PMC Scholia
8. Interleukin-26 promotes the proliferation and activation of hepatic stellate cells to exacerbate liver fibrosis by the TGF-β1/Smad2 signaling pathway. Zhang X, Xie X, Wang Y, Li W, Lin Z. Int J Clin Exp Pathol. 2019 Dec 1;12(12):4271–9. PubMed Europe PMC Scholia
9. The Microarchitecture of Pancreatic Cancer as Measured by Diffusion-Weighted Magnetic Resonance Imaging Is Altered by T Cells with a Tumor Promoting Th17 Phenotype. Mayer P, Linnebacher A, Glennemeier-Marke H, Marnet N, Bergmann F, Hackert T, et al. Int J Mol Sci. 2020 Jan 5;21(1):346. PubMed Europe PMC Scholia
10. Sputum IL-26 Is Overexpressed in Severe Asthma and Induces Proinflammatory Cytokine Production and Th17 Cell Generation: A Case-Control Study of Women. Louhaichi S, Mlika M, Hamdi B, Hamzaoui K, Hamzaoui A. J Asthma Allergy. 2020 Feb 3;13:95–107. PubMed Europe PMC Scholia
11. Interleukin 26 Skews Macrophage Polarization Towards M1 Phenotype by Activating cJUN and the NF-κB Pathway. Lin YH, Wang YH, Peng YJ, Liu FC, Lin GJ, Huang SH, et al. Cells. 2020 Apr 10;9(4):938. PubMed Europe PMC Scholia
12. IL-26 mediates epidermal growth factor receptor-tyrosine kinase inhibitor resistance through endoplasmic reticulum stress signaling pathway in triple-negative breast cancer cells. Itoh T, Hatano R, Horimoto Y, Yamada T, Song D, Otsuka H, et al. Cell Death Dis. 2021 May 21;12(6):520. PubMed Europe PMC Scholia
13. Interleukin-26 Has Synergistic Catabolic Effects with Palmitate in Human Articular Chondrocytes via the TLR4-ERK1/2-c-Jun Signaling Pathway. Chen YT, Wang CC, Cheng CP, Liu FC, Lee CH, Lee HS, et al. Cells. 2021 Sep 21;10(9):2500. PubMed Europe PMC Scholia