Fatty acid oxidation (WP91)

Saccharomyces cerevisiae

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In most organisms, the primary mode of fatty acid catabolism is oxidation. The oxidation cycle catalyzes the complete oxidation of a fatty acid molecule, removing two carbon atoms (in the form of acetyl-CoA) with each turn of the cycle. The subcellular location in which oxidation occurs varies by organism; in bacteria, oxidation occurs in the cytoplasm, whereas in mammalian cells it occurs in both the mitochondria and the peroxisome. In contrast, oxidation in S. cerevisiae, plants, and most other fungi occurs exclusively in the peroxisome. Description from YeastPathways

Authors

Jessica Heckman , Martijn Van Iersel , Egon Willighagen , Christine Chichester , and Kristina Hanspers

Activity

last edited

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Organisms

Saccharomyces cerevisiae

Communities

Annotations

Pathway Ontology

classic metabolic pathway fatty acid degradation pathway

Participants

Label Type Compact URI Comment
fatty acid Metabolite chebi:35366
a 3-oxoacyl-CoA Metabolite chebi:57347
(3S)-3-hydroxyacyl-CoA Metabolite chebi:15455
AMP Metabolite chebi:16027
H2O Metabolite hmdb:HMDB02111
NAD Metabolite hmdb:HMDB00902
cis-delta-2-enoyl-CoA Metabolite kegg.compound:C05057
H+ Metabolite hmdb:HMDB59597
O2 Metabolite chebi:15379
trans-delta-2-enoyl-CoA Metabolite kegg.compound:C00658
NADH Metabolite cas:53-84-9
pyrophosphate Metabolite cas:2466-09-3
acetyl-CoA Metabolite cas:72-89-9
acyl(n-2)-CoA Metabolite chebi:17984
acyl-CoA Metabolite chebi:17984
Coenzyme A Metabolite cas:64885-97-8
H2O2 Metabolite hmdb:HMDB0003125
ATP Metabolite cas:1927-31-7
FAA1 GeneProduct sgd:S000005844
FAA3 GeneProduct sgd:S000001271
ECI1 GeneProduct sgd:S000004274
DCI1 GeneProduct sgd:S000005706
POX1 GeneProduct sgd:S000003173
POT1 GeneProduct sgd:S000001422
FAA4 GeneProduct sgd:S000004860
FAT1 GeneProduct sgd:S000000245
FOX2 GeneProduct sgd:S000001717
FAA2 GeneProduct sgd:S000000817

References

  1. Fatty acid metabolism in Saccharomyces cerevisiae. van Roermund CWT, Waterham HR, Ijlst L, Wanders RJA. Cell Mol Life Sci. 2003 Sep;60(9):1838–51. PubMed Europe PMC Scholia
  2. URL: https://pathway.yeastgenome.org/YEAST/NEW-IMAGE?type=NIL&object=YEAST-FAO-PWY