Ganglio sphingolipid metabolism (WP1423)

Homo sapiens

Sphingolipids are metabolites used to make cell-cell and cell-substratum interactions possible. This pathway describes how they are synthesized.

Authors

Kristina Hanspers , Michiel Adriaens , Alex Pico , Egon Willighagen , Martina Summer-Kutmon , Zahra Roudbari , Denise Slenter , and Eric Weitz

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

sphingolipid metabolic pathway ganglioside metabolic pathway sphingolipid biosynthetic pathway

Participants

Label Type Compact URI Comment
Fuc-GM1 Metabolite chebi:90189
Fuc-GD1b Metabolite chebi:90265
O-Acetylated GD3 Metabolite pubchem.compound:73427362
GT1aA Metabolite lipidmaps:LMSP0601BF00
GalNAc-GD1a Metabolite lipidmaps:LMSP0601BG00
GQ1bA Metabolite lipidmaps:LMSP0601BJ00
Gal-GD1b Metabolite lipidmaps:LMSP0601BH00
GalNAc-GM1 Metabolite lipidmaps:LMSP0601BC00
GD1aA Metabolite lipidmaps:LMSP0601BE00
GalNAc-GM1b Metabolite pubchem.compound:73427345
GD1A Metabolite hmdb:HMDB0011777
O-Acetylated GT3 Metabolite kegg.glycan:G00170
GT2 Metabolite pubchem.compound:53481325
GD3 Metabolite hmdb:HMDB0004913
GQ1bA Metabolite hmdb:HMDB0004928
GA2 Metabolite hmdb:HMDB0004898
GM1a Metabolite hmdb:HMDB0004855
GD1a Metabolite hmdb:HMDB0004853
GM3 Metabolite hmdb:HMDB0004844
GM1b Metabolite pubchem.compound:53239726
GQ1c Metabolite pubchem.compound:53481235
GT1b Metabolite hmdb:HMDB0004927
GP1c Metabolite lipidmaps:LMSP0601AX00
GA1 Metabolite hmdb:HMDB0004910
GM2 Metabolite hmdb:HMDB0004938
GD1b Metabolite hmdb:HMDB0004926
GT1a Metabolite pubchem.compound:45259173
LacCer Metabolite hmdb:HMDB0006750
GD2 Metabolite hmdb:HMDB0004925
GT1c Metabolite pubchem.compound:53481295
GD1c Metabolite lipidmaps:LMSP0601BN00
GT3 Metabolite pubchem.compound:53481355
B3GALT4 GeneProduct ensembl:ENSG00000235863 2.4.1.62
B4GALNT1 GeneProduct ncbigene:2583
ST6GALNAC6 GeneProduct ensembl:ENSG00000160408
O-AcetylT GeneProduct ensembl:ENSG00000169359
ST6GALNAC6 GeneProduct ncbigene:30815
B4GALNT1 GeneProduct ncbigene:2583 2.4.1.92
FUT1 GeneProduct ncbigene:2523
ST8SIA5 GeneProduct ensembl:ENSG00000101638
A3GALT2 GeneProduct ncbigene:127550
ST3GAL2 GeneProduct ensembl:ENSG00000157350 2.4.99.4
ST3GAL5 GeneProduct ncbigene:8869
ST8SIA5 GeneProduct ncbigene:29906
ST8SIA3 GeneProduct ncbigene:51046
ST3GAL1 GeneProduct ensembl:ENSG00000008513
B3GAL GeneProduct ensembl:ENSG00000172318
GM3 Synthase GeneProduct ensembl:ENSG00000115525 2.4.99.9
ST8SIA1 GeneProduct ensembl:ENSG00000111728 2.4.99.8
ST8Sia1 GeneProduct ensembl:ENSG00000111728 2.4.99.8
ST3GAL2 GeneProduct ensembl:ENSG00000157350

References

  1. Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics. Merrill AH Jr. Chem Rev. 2011 Oct 12;111(10):6387–422. PubMed Europe PMC Scholia