Thick ascending limb transporters (WP3882)

Rattus norvegicus

Authors

Agustin Gonzalez-Vicente , Alex Pico , Kristina Hanspers , Egon Willighagen , Denise Slenter , and Eric Weitz

Activity

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Cited In

• Enhanced glucose metabolism through activation of HIF-1α covers the energy demand in a rat embryonic heart primordium after heartbeat initiation (2022).
• Unraveling the blood transcriptome after real-life exposure of Wistar-rats to PM2.5, PM1 and water-soluble metals in the ambient air (2020).
• Developing Tools for Analysis of Renal Genomic Data: An Invitation to Participate (2017).

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Organisms

Rattus norvegicus

Communities

Renal Genomics Pathways

Annotations

Cell Type Ontology

transporting cell kidney loop of Henle thick ascending limb epithelial cell kidney epithelial cell

Pathway Ontology

transport pathway regulatory pathway

Disease Ontology

Bartter disease

References

1. Ion transport mechanisms in thick ascending limb of Henle’s loop of mammalian nephron. Greger R. Physiol Rev. 1985 Jul;65(3):760–97. PubMed Europe PMC Scholia
2. Control of NaCl transport in the thick ascending limb. Hebert SC, Andreoli TE. Am J Physiol. 1984 Jun;246(6 Pt 2):F745-56. PubMed Europe PMC Scholia
3. Sodium-potassium-adenosinetriphosphatase-dependent sodium transport in the kidney: hormonal control. Féraille E, Doucet A. Physiol Rev. 2001 Jan;81(1):345–418. PubMed Europe PMC Scholia
4. Basolateral membrane K+ channels in renal epithelial cells. Hamilton KL, Devor DC. Am J Physiol Renal Physiol. 2012 May 1;302(9):F1069-81. PubMed Europe PMC Scholia
5. Membrane-associated aquaporin-1 facilitates osmotically driven water flux across the basolateral membrane of the thick ascending limb. Cabral PD, Herrera M. Am J Physiol Renal Physiol. 2012 Sep;303(5):F621-9. PubMed Europe PMC Scholia
6. Thick ascending limb of the loop of Henle. Mount DB. Clin J Am Soc Nephrol. 2014 Nov 7;9(11):1974–86. PubMed Europe PMC Scholia
7. Deep Sequencing in Microdissected Renal Tubules Identifies Nephron Segment-Specific Transcriptomes. Lee JW, Chou CL, Knepper MA. J Am Soc Nephrol. 2015 Nov;26(11):2669–77. PubMed Europe PMC Scholia