Thick ascending limb transporters (WP3882)

Rattus norvegicus

Open in new tab Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
This pathway shows the main transporters in the thick ascending limb of the Loop of Henle

Authors

Agustin Gonzalez-Vicente , Alex Pico , Kristina Hanspers , Egon Willighagen , Denise Slenter , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Rattus norvegicus

Communities

Renal Genomics Pathways

Annotations

Cell Type Ontology

transporting cell kidney loop of Henle thick ascending limb epithelial cell kidney epithelial cell

Pathway Ontology

transport pathway regulatory pathway

Disease Ontology

Bartter disease

Participants

Label Type Compact URI Comment
Na Metabolite hmdb:HMDB0000588
K Metabolite hmdb:HMDB0000586
2 Cl Metabolite hmdb:HMDB0000492
2 K Metabolite hmdb:HMDB0000586
3 Na Metabolite hmdb:HMDB0000588
H Metabolite hmdb:HMDB0059597
CO2 Metabolite hmdb:HMDB0001967
H2O Metabolite hmdb:HMDB0002111
HCO3 Metabolite hmdb:HMDB0000595
Cl Metabolite hmdb:HMDB0000492
ATP Metabolite hmdb:HMDB0000538
ADP Metabolite hmdb:HMDB0001341
NHE3 GeneProduct ncbigene:24784
NBCn1 GeneProduct ncbigene:117955
ROMK 2/3 GeneProduct ncbigene:24521
NKCC2 GeneProduct ncbigene:25065
ATP1A1 GeneProduct ncbigene:24211
Barttin GeneProduct ncbigene:79430
KCC4 GeneProduct ncbigene:308069
Aquaporin 1 GeneProduct ncbigene:25240
CLC-K2 GeneProduct ncbigene:79430
CA2 GeneProduct ncbigene:54231
CA4 GeneProduct ncbigene:29242
ATP1B1 GeneProduct ncbigene:25650
KCNK12 GeneProduct ncbigene:64119
KCNQ1 GeneProduct ncbigene:84020
KCNK13 GeneProduct ncbigene:64120
KCNJ13 GeneProduct ncbigene:94341
KCNJ16 GeneProduct ncbigene:29719
Fxyd2 GeneProduct ncbigene:29639
CLC-K1 GeneProduct ncbigene:79425
NHE2 GeneProduct ncbigene:24783

References

  1. Ion transport mechanisms in thick ascending limb of Henle’s loop of mammalian nephron. Greger R. Physiol Rev. 1985 Jul;65(3):760–97. PubMed Europe PMC Scholia
  2. Control of NaCl transport in the thick ascending limb. Hebert SC, Andreoli TE. Am J Physiol. 1984 Jun;246(6 Pt 2):F745-56. PubMed Europe PMC Scholia
  3. Sodium-potassium-adenosinetriphosphatase-dependent sodium transport in the kidney: hormonal control. Féraille E, Doucet A. Physiol Rev. 2001 Jan;81(1):345–418. PubMed Europe PMC Scholia
  4. Basolateral membrane K+ channels in renal epithelial cells. Hamilton KL, Devor DC. Am J Physiol Renal Physiol. 2012 May 1;302(9):F1069-81. PubMed Europe PMC Scholia
  5. Membrane-associated aquaporin-1 facilitates osmotically driven water flux across the basolateral membrane of the thick ascending limb. Cabral PD, Herrera M. Am J Physiol Renal Physiol. 2012 Sep;303(5):F621-9. PubMed Europe PMC Scholia
  6. Thick ascending limb of the loop of Henle. Mount DB. Clin J Am Soc Nephrol. 2014 Nov 7;9(11):1974–86. PubMed Europe PMC Scholia
  7. Deep Sequencing in Microdissected Renal Tubules Identifies Nephron Segment-Specific Transcriptomes. Lee JW, Chou CL, Knepper MA. J Am Soc Nephrol. 2015 Nov;26(11):2669–77. PubMed Europe PMC Scholia