Wnt/Beta-catenin signaling inhibitors in current and past clinical trials (WP5442)

Homo sapiens

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Wnt/Beta-catenin signaling inhibitors in current and past clinical trials

Authors

Andra Waagmeester , Alex Pico , Egon Willighagen , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

signaling pathway Wnt signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
ETC-1922159 Metabolite wikidata:Q124448578
SM08502 Metabolite wikidata:Q124448796
RXC004 Metabolite wikidata:Q124439695
OMP-18R5 Metabolite wikidata:Q7915216
WNT-974 Metabolite pubchem.compound:46926973
PRI 724 Metabolite wikidata:Q123515698
OMP-54f28 Metabolite wikidata:Q124625115
CGX-1321 Metabolite wikidata:Q124448546
OTSA101-DTPA-90Y Metabolite wikidata:Q124449028
CBP GeneProduct uniprot:Q92793
PORCN GeneProduct ensembl:ENSG00000102312
LRP5 GeneProduct ensembl:ENSG00000162337
WNT GeneProduct interpro:IPR005817
CTNNB1 GeneProduct ensembl:ENSG00000168036
LRP6 GeneProduct ensembl:ENSG00000070018
Frizzled Protein interpro:IPR000539

References

  1. Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex. Jung YS, Park JI. Exp Mol Med. 2020 Feb;52(2):183–91. PubMed Europe PMC Scholia