Post-COVID neuroinflammation (WP5485)

Homo sapiens

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Post-COVID is the sequela disease of COVID-19, a SARS-CoV-2 infectious disease that is characterized by long-term persistent symptoms. To understand the underlying disease mechanisms of post-COVID and the role of persistent neuroinflammation herein, this pathway visualizes the direct and indirect route of SARS-CoV-2-mediated neuroinflammation, which may induce dysautonomia, a major post-COVID symptom. The direct and indirect route are subdivided in a neurological and hematological, and a neurological and humoral route, respectively.

Authors

Laura Admiraal , Egon Willighagen , Kristina Hanspers , and Eric Weitz

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Disease Ontology

COVID-19

Cell Type Ontology

neutrophil macrophage natural killer cell monocyte

Pathway Ontology

signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
substance P(3+) Metabolite chebi:190692
NF-κB inhibitor Metabolite chebi:73240
GFAP GeneProduct uniprot:P14136
MAPK1 Protein uniprot:P28482
IL18 Protein uniprot:Q14116
INF2A Protein uniprot:P01563
TLR3 Protein uniprot:O15455
IL8 Protein uniprot:P10145
TLR4 Protein uniprot:O00206
IL4 Protein uniprot:P05112
IFNG Protein uniprot:P01579
IL2 Protein uniprot:P60568
HMGB1 Protein uniprot:P09429 DAMP
IL10 Protein uniprot:P22301
TLR8 Protein uniprot:Q9NR97
TNF Protein uniprot:P01375
IL6 Protein uniprot:P05231
E protein Protein uniprot:P0DTC4
IL12A Protein uniprot:P29459
TLR7 Protein uniprot:Q9NYK1
CCL11 Protein uniprot:P51671
FURIN Protein uniprot:P09958
ACE2 Protein uniprot:Q9BYF1
TMPRSS2 Protein uniprot:O15393
IL1B Protein uniprot:P01584
IL1A Protein uniprot:P01583
CXCL8 Protein uniprot:P10145

References

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