Folate metabolism (WP176)

Homo sapiens

Authors

Egoyenechea , Martijn Van Iersel , Thomas Kelder , Kristina Hanspers , Jill Dunham , Damariz Rivero , Jildau Bouwman , Alex Pico , Andra Waagmeester , Egon Willighagen , Martina Summer-Kutmon , Denise Slenter , Friederike Ehrhart , Youssef Walid , Eric Weitz , and Marvin Martens

Activity

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Cited In

• Heterogeneity of Lipid and Protein Cartilage Profiles Associated with Human Osteoarthritis with or without Type 2 Diabetes Mellitus (2021).
• Identification of biomarkers and pathways for the SARS-CoV-2 infections that make complexities in pulmonary arterial hypertension patients (2021).
• Network-based identification genetic effect of SARS-CoV-2 infections to Idiopathic pulmonary fibrosis (IPF) patients (2020).
• Long Term Culture of the A549 Cancer Cell Line Promotes Multilamellar Body Formation and Differentiation towards an Alveolar Type II Pneumocyte Phenotype (2016).
• In silico transcriptional analysis of asymptomatic and severe COVID-19 patients reveals the susceptibility of severe patients to other comorbidities and non-viral pathological conditions (2023).

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Organisms

Homo sapiens

Communities

Micronutrients Serious Request 2024 - MetaKids

Annotations

Pathway Ontology

folate metabolic pathway

References

1. The c-rel protooncogene product c-Rel but not NF-kappa B binds to the intronic region of the human interferon-gamma gene at a site related to an interferon-stimulable response element. Sica A, Tan TH, Rice N, Kretzschmar M, Ghosh P, Young HA. Proc Natl Acad Sci U S A. 1992 Mar 1;89(5):1740–4. PubMed Europe PMC Scholia
2. Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product. Santhanam U, Ray A, Sehgal PB. Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7605–9. PubMed Europe PMC Scholia
3. Inhibition of human neutrophil superoxide generation by alpha 1-antichymotrypsin. Kilpatrick L, Johnson JL, Nickbarg EB, Wang ZM, Clifford TF, Banach M, et al. J Immunol. 1991 Apr 1;146(7):2388–93. PubMed Europe PMC Scholia
4. Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa B. Collart MA, Baeuerle P, Vassalli P. Mol Cell Biol. 1990 Apr;10(4):1498–506. PubMed Europe PMC Scholia
5. Kappa B-specific DNA binding proteins: role in the regulation of human interleukin-2 gene expression. Hoyos B, Ballard DW, Böhnlein E, Siekevitz M, Greene WC. Science. 1989 Apr 28;244(4903):457–60. PubMed Europe PMC Scholia
6. Urinary 8-hydroxy-2’-deoxyguanosine as a biological marker of in vivo oxidative DNA damage. Shigenaga MK, Gimeno CJ, Ames BN. Proc Natl Acad Sci U S A. 1989 Dec;86(24):9697–701. PubMed Europe PMC Scholia
7. Inhibition of thromboxane formation in vivo and ex vivo: implications for therapy with platelet inhibitory drugs. Reilly IA, FitzGerald GA. Blood. 1987 Jan;69(1):180–6. PubMed Europe PMC Scholia
8. Effects of serum amyloid A protein (SAA) on composition, size, and density of high density lipoproteins in subjects with myocardial infarction. Clifton PM, Mackinnon AM, Barter PJ. J Lipid Res. 1985 Dec;26(12):1389–98. PubMed Europe PMC Scholia
9. Biochemistry of tryptophan in health and disease. Bender DA. Mol Aspects Med. 1983;6(2):101–97. PubMed Europe PMC Scholia
10. Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: evidence for a positive autoregulatory loop. Hiscott J, Marois J, Garoufalis J, D’Addario M, Roulston A, Kwan I, et al. Mol Cell Biol. 1993 Oct;13(10):6231–40. PubMed Europe PMC Scholia
11. Repression of interleukin-2 and interleukin-4 promoters by tumor suppressor protein p53. Pesch J, Brehm U, Staib C, Grummt F. J Interferon Cytokine Res. 1996 Aug;16(8):595–600. PubMed Europe PMC Scholia
12. Relationship of plasma folic acid and status of DNA methylation in human gastric cancer. Fang JY, Xiao SD, Zhu SS, Yuan JM, Qiu DK, Jiang SJ. J Gastroenterol. 1997 Apr;32(2):171–5. PubMed Europe PMC Scholia
13. A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation. Paz K, Hemi R, LeRoith D, Karasik A, Elhanany E, Kanety H, et al. J Biol Chem. 1997 Nov 21;272(47):29911–8. PubMed Europe PMC Scholia
14. Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria. Leclerc D, Wilson A, Dumas R, Gafuik C, Song D, Watkins D, et al. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3059–64. PubMed Europe PMC Scholia
15. The metabolism of homocysteine: pathways and regulation. Finkelstein JD. Eur J Pediatr. 1998 Apr;157 Suppl 2:S40-4. PubMed Europe PMC Scholia
16. Anxiety and adipose essential fatty acid precursors for prostaglandin E1 and E2. Mamalakis G, Kafatos A, Tornaritis M, Alevizos B. J Am Coll Nutr. 1998 Jun;17(3):239–43. PubMed Europe PMC Scholia
17. Inflammation, antichymotrypsin, and lipid metabolism: autogenic etiology of Alzheimer’s disease. Janciauskiene S, Wright HT. Bioessays. 1998 Dec;20(12):1039–46. PubMed Europe PMC Scholia
18. Lipid peroxidation-DNA damage by malondialdehyde. Marnett LJ. Mutat Res. 1999 Mar 8;424(1–2):83–95. PubMed Europe PMC Scholia
19. Molecular basis for methionine synthase reductase deficiency in patients belonging to the cblE complementation group of disorders in folate/cobalamin metabolism. Wilson A, Leclerc D, Rosenblatt DS, Gravel RA. Hum Mol Genet. 1999 Oct;8(11):2009–16. PubMed Europe PMC Scholia
20. Tissue-specific functions of individual glutathione peroxidases. Brigelius-Flohé R. Free Radic Biol Med. 1999 Nov;27(9–10):951–65. PubMed Europe PMC Scholia
21. Relationships between homocysteine, factor VIIa, and thrombin generation in acute coronary syndromes. Al-Obaidi MK, Philippou H, Stubbs PJ, Adami A, Amersey R, Noble MM, et al. Circulation. 2000 Feb 1;101(4):372–7. PubMed Europe PMC Scholia
22. Serine hydroxymethyltransferase and threonine aldolase: are they identical? Ogawa H, Gomi T, Fujioka M. Int J Biochem Cell Biol. 2000 Mar;32(3):289–301. PubMed Europe PMC Scholia
23. Folate and carcinogenesis: an integrated scheme. Choi SW, Mason JB. J Nutr. 2000 Feb;130(2):129–32. PubMed Europe PMC Scholia
24. Altered folate metabolism and disposition in mothers affected by a spina bifida pregnancy: influence of 677c --> t methylenetetrahydrofolate reductase and 2756a --> g methionine synthase genotypes. Lucock M, Daskalakis I, Briggs D, Yates Z, Levene M. Mol Genet Metab. 2000 May;70(1):27–44. PubMed Europe PMC Scholia
25. Free radicals and hearing. Cause, consequence, and criteria. Evans P, Halliwell B. Ann N Y Acad Sci. 1999 Nov 28;884:19–40. PubMed Europe PMC Scholia
26. Folic acid: nutritional biochemistry, molecular biology, and role in disease processes. Lucock M. Mol Genet Metab. 2000;71(1–2):121–38. PubMed Europe PMC Scholia
27. Determination of S-adenosylmethionine and S-adenosylhomocysteine in plasma and cerebrospinal fluid by stable-isotope dilution tandem mass spectrometry. Struys EA, Jansen EE, de Meer K, Jakobs C. Clin Chem. 2000 Oct;46(10):1650–6. PubMed Europe PMC Scholia
28. Nitric oxide is a physiological substrate for mammalian peroxidases. Abu-Soud HM, Hazen SL. J Biol Chem. 2000 Dec 1;275(48):37524–32. PubMed Europe PMC Scholia
29. Does inflammation contribute to thrombotic events? Esmon CT. Haemostasis. 2000;30 Suppl 2:34–40. PubMed Europe PMC Scholia
30. Hemoglobin variants and determination of glycated hemoglobin (HbA1c). Schnedl WJ, Liebminger A, Roller RE, Lipp RW, Krejs GJ. Diabetes Metab Res Rev. 2001;17(2):94–8. PubMed Europe PMC Scholia
31. Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response. Zhang C, Cai Y, Adachi MT, Oshiro S, Aso T, Kaufman RJ, et al. J Biol Chem. 2001 Sep 21;276(38):35867–74. PubMed Europe PMC Scholia
32. Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3. Xie S, Wang Q, Wu H, Cogswell J, Lu L, Jhanwar-Uniyal M, et al. J Biol Chem. 2001 Sep 28;276(39):36194–9. PubMed Europe PMC Scholia
33. Elements of the fibrinolytic system. Lijnen HR. Ann N Y Acad Sci. 2001;936:226–36. PubMed Europe PMC Scholia
34. Determinants of cobalamin status in newborns. Bjørke Monsen AL, Ueland PM, Vollset SE, Guttormsen AB, Markestad T, Solheim E, et al. Pediatrics. 2001 Sep;108(3):624–30. PubMed Europe PMC Scholia
35. The covalent FAD of monoamine oxidase: structural and functional role and mechanism of the flavinylation reaction. Edmondson DE, Newton-Vinson P. Antioxid Redox Signal. 2001 Oct;3(5):789–806. PubMed Europe PMC Scholia
36. The effects of folate supplementation on some coagulation parameters and oxidative status surrogates. Mayer O Jr, Simon J, Rosolová H, Hromádka M, Subrt I, Vobrubová I. Eur J Clin Pharmacol. 2002 Apr;58(1):1–5. PubMed Europe PMC Scholia
37. Effect of riboflavin supplementation on plasma homocysteine in elderly people with low riboflavin status. McKinley MC, McNulty H, McPartlin J, Strain JJ, Scott JM. Eur J Clin Nutr. 2002 Sep;56(9):850–6. PubMed Europe PMC Scholia
38. Prostaglandin E synthase. Murakami M, Nakatani Y, Tanioka T, Kudo I. Prostaglandins Other Lipid Mediat. 2002 Aug;68–69:383–99. PubMed Europe PMC Scholia
39. Prostaglandin F synthase. Watanabe K. Prostaglandins Other Lipid Mediat. 2002 Aug;68–69:401–7. PubMed Europe PMC Scholia
40. Thromboxane synthase: structure and function of protein and gene. Wang LH, Kulmacz RJ. Prostaglandins Other Lipid Mediat. 2002 Aug;68–69:409–22. PubMed Europe PMC Scholia
41. Folate: a key to optimizing health and reducing disease risk in the elderly. Rampersaud GC, Kauwell GPA, Bailey LB. J Am Coll Nutr. 2003 Feb;22(1):1–8. PubMed Europe PMC Scholia
42. Folic acid says NO to vascular diseases. Das UN. Nutrition. 2003;19(7–8):686–92. PubMed Europe PMC Scholia
43. 5-lipoxygenase and FLAP. Peters-Golden M, Brock TG. Prostaglandins Leukot Essent Fatty Acids. 2003;69(2–3):99–109. PubMed Europe PMC Scholia
44. Ligand binding-induced conformational changes in riboflavin kinase: structural basis for the ordered mechanism. Karthikeyan S, Zhou Q, Osterman AL, Zhang H. Biochemistry. 2003 Nov 4;42(43):12532–8. PubMed Europe PMC Scholia
45. A study on soluble intercellular adhesion molecule-1 and selenium in patients with rheumatoid arthritis complicated by vasculitis. Witkowska AM, Kuryliszyn-Moskal A, Borawska MH, Hukałowicz K, Markiewicz R. Clin Rheumatol. 2003 Dec;22(6):414–9. PubMed Europe PMC Scholia
46. Molecular basis of homocysteine toxicity in humans. Jakubowski H. Cell Mol Life Sci. 2004 Feb;61(4):470–87. PubMed Europe PMC Scholia
47. Endothelial function in post-menopausal women: effect of folic acid supplementation. Paradisi G, Cucinelli F, Mele MC, Barini A, Lanzone A, Caruso A. Hum Reprod. 2004 Apr;19(4):1031–5. PubMed Europe PMC Scholia
48. Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease. Zheng L, Nukuna B, Brennan ML, Sun M, Goormastic M, Settle M, et al. J Clin Invest. 2004 Aug;114(4):529–41. PubMed Europe PMC Scholia
49. Diet and lifestyle are associated with serum C-reactive protein concentrations in a population-based study. Bertran N, Camps J, Fernandez-Ballart J, Arija V, Ferre N, Tous M, et al. J Lab Clin Med. 2005 Jan;145(1):41–6. PubMed Europe PMC Scholia
50. Methionine oxidation by reactive oxygen species: reaction mechanisms and relevance to Alzheimer’s disease. Schöneich C. Biochim Biophys Acta. 2005 Jan 17;1703(2):111–9. PubMed Europe PMC Scholia
51. Myeloperoxidase: friend and foe. Klebanoff SJ. J Leukoc Biol. 2005 May;77(5):598–625. PubMed Europe PMC Scholia
52. Identification of amino acids required for the functional up-regulation of human dihydrofolate reductase protein in response to antifolate Treatment. Skacel N, Menon LG, Mishra PJ, Peters R, Banerjee D, Bertino JR, et al. J Biol Chem. 2005 Jun 17;280(24):22721–31. PubMed Europe PMC Scholia
53. Fibrinogen and fibrin. Weisel JW. Adv Protein Chem. 2005;70:247–99. PubMed Europe PMC Scholia
54. New insights into the regulation of HDL metabolism and reverse cholesterol transport. Lewis GF, Rader DJ. Circ Res. 2005 Jun 24;96(12):1221–32. PubMed Europe PMC Scholia
55. Serum amyloid A promotes cholesterol efflux mediated by scavenger receptor B-I. van der Westhuyzen DR, Cai L, de Beer MC, de Beer FC. J Biol Chem. 2005 Oct 28;280(43):35890–5. PubMed Europe PMC Scholia
56. The serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble gp130 (sgp130) in different tumour stages. Correlation between the two parameters in progression of malignancy. Kovacs E. Biomed Pharmacother. 2005 Oct;59(9):498–500. PubMed Europe PMC Scholia
57. Myeloperoxidase metabolizes thiocyanate in a reaction driven by nitric oxide. Galijasevic S, Saed GM, Hazen SL, Abu-Soud HM. Biochemistry. 2006 Jan 31;45(4):1255–62. PubMed Europe PMC Scholia
58. Modification of low-density lipoprotein by myeloperoxidase-derived oxidants and reagent hypochlorous acid. Malle E, Marsche G, Arnhold J, Davies MJ. Biochim Biophys Acta. 2006 Apr;1761(4):392–415. PubMed Europe PMC Scholia
59. NF-kappaB1 (p50) homodimers differentially regulate pro- and anti-inflammatory cytokines in macrophages. Cao S, Zhang X, Edwards JP, Mosser DM. J Biol Chem. 2006 Sep 8;281(36):26041–50. PubMed Europe PMC Scholia
60. Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit. Schumm K, Rocha S, Caamano J, Perkins ND. EMBO J. 2006 Oct 18;25(20):4820–32. PubMed Europe PMC Scholia
61. Insulin resistance and oxidative stress interdependency in non-alcoholic fatty liver disease. Videla LA, Rodrigo R, Araya J, Poniachik J. Trends Mol Med. 2006 Dec;12(12):555–8. PubMed Europe PMC Scholia
62. Glutathione peroxidases and redox-regulated transcription factors. Brigelius-Flohé R. Biol Chem. 2006;387(10–11):1329–35. PubMed Europe PMC Scholia
63. Human glycinamide ribonucleotide transformylase: active site mutants as mechanistic probes. Manieri W, Moore ME, Soellner MB, Tsang P, Caperelli CA. Biochemistry. 2007 Jan 9;46(1):156–63. PubMed Europe PMC Scholia
64. Association between the intake of vitamins and trace elements from supplements and C-reactive protein: results of the MONICA/KORA Augsburg study. Scheurig AC, Thorand B, Fischer B, Heier M, Koenig W. Eur J Clin Nutr. 2008 Jan;62(1):127–37. PubMed Europe PMC Scholia
65. Removal of triacylglycerols from chylomicrons and VLDL by capillary beds: the basis of lipoprotein remnant formation. Karpe F, Bickerton AS, Hodson L, Fielding BA, Tan GD, Frayn KN. Biochem Soc Trans. 2007 Jun;35(Pt 3):472–6. PubMed Europe PMC Scholia
66. Properties of an unusual heme cofactor in PLP-dependent cystathionine beta-synthase. Singh S, Madzelan P, Banerjee R. Nat Prod Rep. 2007 Jun;24(3):631–9. PubMed Europe PMC Scholia
67. Rosiglitazone attenuates NF-kappaB-dependent ICAM-1 and TNF-alpha production caused by homocysteine via inhibiting ERK1/2/p38MAPK activation. Bai YP, Liu YH, Chen J, Song T, You Y, Tang ZY, et al. Biochem Biophys Res Commun. 2007 Aug 17;360(1):20–6. PubMed Europe PMC Scholia
68. Glucose metabolism and catecholamines. Barth E, Albuszies G, Baumgart K, Matejovic M, Wachter U, Vogt J, et al. Crit Care Med. 2007 Sep;35(9 Suppl):S508-18. PubMed Europe PMC Scholia
69. Serum selenium concentrations correlate significantly with inflammatory biomarker high-sensitive CRP levels in Hungarian gestational diabetic and healthy pregnant women at mid-pregnancy. Molnar J, Garamvolgyi Z, Herold M, Adanyi N, Somogyi A, Rigo J Jr. Biol Trace Elem Res. 2008 Jan;121(1):16–22. PubMed Europe PMC Scholia
70. Structures of prostacyclin synthase and its complexes with substrate analog and inhibitor reveal a ligand-specific heme conformation change. Li YC, Chiang CW, Yeh HC, Hsu PY, Whitby FG, Wang LH, et al. J Biol Chem. 2008 Feb 1;283(5):2917–26. PubMed Europe PMC Scholia
71. Plasma S-adenosylhomocysteine is a better biomarker of atherosclerosis than homocysteine in apolipoprotein E-deficient mice fed high dietary methionine. Liu C, Wang Q, Guo H, Xia M, Yuan Q, Hu Y, et al. J Nutr. 2008 Feb;138(2):311–5. PubMed Europe PMC Scholia
72. Roles of MAPK and NF-kappaB in interleukin-6 induction by lipopolysaccharide in vascular smooth muscle cells. Son YH, Jeong YT, Lee KA, Choi KH, Kim SM, Rhim BY, et al. J Cardiovasc Pharmacol. 2008 Jan;51(1):71–7. PubMed Europe PMC Scholia
73. Cyclooxygenase and prostaglandin synthases in atherosclerosis: recent insights and future perspectives. Cipollone F, Cicolini G, Bucci M. Pharmacol Ther. 2008 May;118(2):161–80. PubMed Europe PMC Scholia
74. Evolution of catalases from bacteria to humans. Zamocky M, Furtmüller PG, Obinger C. Antioxid Redox Signal. 2008 Sep;10(9):1527–48. PubMed Europe PMC Scholia
75. F2-isoprostanes in human health and diseases: from molecular mechanisms to clinical implications. Basu S. Antioxid Redox Signal. 2008 Aug;10(8):1405–34. PubMed Europe PMC Scholia
76. The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier. Zhao R, Qiu A, Tsai E, Jansen M, Akabas MH, Goldman ID. Mol Pharmacol. 2008 Sep;74(3):854–62. PubMed Europe PMC Scholia
77. Association between dietary fiber and markers of systemic inflammation in the Women’s Health Initiative Observational Study. Ma Y, Hébert JR, Li W, Bertone-Johnson ER, Olendzki B, Pagoto SL, et al. Nutrition. 2008 Oct;24(10):941–9. PubMed Europe PMC Scholia
78. Oxidative stress in normal and impaired wound repair. Schäfer M, Werner S. Pharmacol Res. 2008 Aug;58(2):165–71. PubMed Europe PMC Scholia
79. FoxO1 integrates insulin signaling to VLDL production. Kamagate A, Dong HH. Cell Cycle. 2008 Oct;7(20):3162–70. PubMed Europe PMC Scholia
80. Oxidative modification of LDL: its pathological role in atherosclerosis. Itabe H. Clin Rev Allergy Immunol. 2009 Aug;37(1):4–11. PubMed Europe PMC Scholia
81. Fructosamine--an underutilized tool in diabetes management: case report and literature review. Youssef D, El Abbassi A, Jordan RM, Peiris AN. Tenn Med. 2008 Nov;101(11):31–3. PubMed Europe PMC Scholia
82. Genetic variants in phosphatidylethanolamine N-methyltransferase and methylenetetrahydrofolate dehydrogenase influence biomarkers of choline metabolism when folate intake is restricted. Ivanov A, Nash-Barboza S, Hinkis S, Caudill MA. J Am Diet Assoc. 2009 Feb;109(2):313–8. PubMed Europe PMC Scholia
83. Structure and mechanism of a eukaryotic FMN adenylyltransferase. Huerta C, Borek D, Machius M, Grishin NV, Zhang H. J Mol Biol. 2009 Jun 5;389(2):388–400. PubMed Europe PMC Scholia
84. Studies of biomarker responses to intervention with riboflavin: a systematic review. Hoey L, McNulty H, Strain JJ. Am J Clin Nutr. 2009 Jun;89(6):1960S-1980S. PubMed Europe PMC Scholia
85. Should D-dimer testing be used to predict the risk of recurrence after discontinuation of anticoagulant therapy for a first unprovoked episode of venous thromboembolism? Wu C, Bates SM. Pol Arch Med Wewn. 2009 Apr;119(4):225–30. PubMed Europe PMC Scholia
86. Protein tyrosine nitration: selectivity, physicochemical and biological consequences, denitration, and proteomics methods for the identification of tyrosine-nitrated proteins. Abello N, Kerstjens HAM, Postma DS, Bischoff R. J Proteome Res. 2009 Jul;8(7):3222–38. PubMed Europe PMC Scholia
87. Role of the MTHFR polymorphisms in cancer risk modification and treatment. Kim YI. Future Oncol. 2009 May;5(4):523–42. PubMed Europe PMC Scholia
88. Human S-adenosylhomocysteine hydrolase: common gene sequence variation and functional genomic characterization. Feng Q, Keshtgarpour M, Pelleymounter LL, Moon I, Kalari KR, Eckloff BW, et al. J Neurochem. 2009 Sep;110(6):1806–17. PubMed Europe PMC Scholia
89. Folate/homocysteine phenotypes and MTHFR 677C>T genotypes are associated with serum levels of monocyte chemoattractant protein-1. Hammons AL, Summers CM, Woodside JV, McNulty H, Strain JJ, Young IS, et al. Clin Immunol. 2009 Oct;133(1):132–7. PubMed Europe PMC Scholia
90. Tetrahydrobiopterin, superoxide, and vascular dysfunction. Vásquez-Vivar J. Free Radic Biol Med. 2009 Oct 15;47(8):1108–19. PubMed Europe PMC Scholia
91. Review article: Coagulation cascade and therapeutics update: relevance to nephrology. Part 1: Overview of coagulation, thrombophilias and history of anticoagulants. Adams RLC, Bird RJ. Nephrology (Carlton). 2009 Aug;14(5):462–70. PubMed Europe PMC Scholia
92. The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake. Bailey SW, Ayling JE. Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15424–9. PubMed Europe PMC Scholia
93. Reversible severe combined immunodeficiency phenotype secondary to a mutation of the proton-coupled folate transporter. Borzutzky A, Crompton B, Bergmann AK, Giliani S, Baxi S, Martin M, et al. Clin Immunol. 2009 Dec;133(3):287–94. PubMed Europe PMC Scholia
94. Proinflammatory cytokines in CRP baseline regulation. Eklund CM. Adv Clin Chem. 2009;48:111–36. PubMed Europe PMC Scholia
95. p53 and the regulation of hepatocyte apoptosis: implications for disease pathogenesis. Amaral JD, Castro RE, Steer CJ, Rodrigues CMP. Trends Mol Med. 2009 Nov;15(11):531–41. PubMed Europe PMC Scholia
96. Associations of plasma homocysteine level with brachial-ankle pulse wave velocity, LDL atherogenicity, and inflammation profile in healthy men. Yun J, Kim JY, Kim OY, Jang Y, Chae JS, Kwak JH, et al. Nutr Metab Cardiovasc Dis. 2011 Feb;21(2):136–43. PubMed Europe PMC Scholia
97. Folate receptor beta is expressed by tumor-associated macrophages and constitutes a marker for M2 anti-inflammatory/regulatory macrophages. Puig-Kröger A, Sierra-Filardi E, Domínguez-Soto A, Samaniego R, Corcuera MT, Gómez-Aguado F, et al. Cancer Res. 2009 Dec 15;69(24):9395–403. PubMed Europe PMC Scholia