Folate metabolism (WP176)
Homo sapiens
The folic acid-centred micronutrient biological network. The most relevant biochemical processes related to folic acid in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying the folic acid centred plasma metabolome. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP176 CPTAC Assay Portal]
Authors
Egoyenechea , Martijn Van Iersel , Thomas Kelder , Kristina Hanspers , Jill Dunham , Damariz Rivero , Jildau Bouwman , Alex Pico , Andra Waagmeester , Egon Willighagen , Martina Summer-Kutmon , Denise Slenter , Friederike Ehrhart , Youssef Walid , Eric Weitz , and Marvin MartensActivity
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Cited In
- Heterogeneity of Lipid and Protein Cartilage Profiles Associated with Human Osteoarthritis with or without Type 2 Diabetes Mellitus (2021).
- Identification of biomarkers and pathways for the SARS-CoV-2 infections that make complexities in pulmonary arterial hypertension patients (2021).
- Network-based identification genetic effect of SARS-CoV-2 infections to Idiopathic pulmonary fibrosis (IPF) patients (2020).
- Long Term Culture of the A549 Cancer Cell Line Promotes Multilamellar Body Formation and Differentiation towards an Alveolar Type II Pneumocyte Phenotype (2016).
- In silico transcriptional analysis of asymptomatic and severe COVID-19 patients reveals the susceptibility of severe patients to other comorbidities and non-viral pathological conditions (2023).
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Organisms
Homo sapiensCommunities
MicronutrientsAnnotations
Pathway Ontology
folate metabolic pathwayLabel | Type | Compact URI | Comment |
---|---|---|---|
PGE1 | Metabolite | hmdb:HMDB0001442 | Prostaglandin E1 |
F2-Isoprostane | Metabolite | wikidata:Q33659470 | |
8-Isoprostaglandin F2a | Metabolite | hmdb:HMDB0005083 | |
PGE2 | Metabolite | hmdb:HMDB0001220 | Prostaglandin E2 |
Thromboxane B2 | Metabolite | hmdb:HMDB0003252 | |
Thromboxane A2 | Metabolite | hmdb:HMDB0001452 | |
PGF2a | Metabolite | hmdb:HMDB0001139 | Prostaglandin F2a |
NADP+ | Metabolite | hmdb:HMDB0000217 | Nicotinamide adenine dinucleotide phosphate-Oxidized |
Cysteine | Metabolite | hmdb:HMDB0000574 | |
H2O2 | Metabolite | hmdb:HMDB0003125 | Hydrogen peroxide |
5,10-Methylene-THF | Metabolite | hmdb:HMDB0001533 | 5,10-Methylenetetrahydrofolate |
5,10-Methenyl-THF | Metabolite | hmdb:HMDB0001354 | 5,10-Methenyltetrahydrofolic acid |
5-Formyl-THF | Metabolite | hmdb:HMDB0001562 | 5-Formyltetrahydrofolate |
10-Formyl-THF | Metabolite | hmdb:HMDB0000972 | 10-formyltetrahydrofolate |
GAR | Metabolite | hmdb:HMDB0002022 | glycinamide ribonucleotide |
FGAR | Metabolite | chebi:18272 | formylglycinamide ribonucleotide |
Dihydrofolate | Metabolite | hmdb:HMDB0001056 | |
5-methyl-THF | Metabolite | hmdb:HMDB0001396 | 5-methyltetrahydrofolatePredominant food folate |
Folate | Metabolite | chebi:37445 | Generic term used to denote both naturally occurring folate in foods (food folate) and the synthetic form of the vitamin (folic acid). |
H2O | Metabolite | hmdb:HMDB0002111 | Glutathione disulfide |
Heme | Metabolite | hmdb:HMDB0003178 | |
THF | Metabolite | hmdb:HMDB0001846 | Tetrahydrofolic acid |
NADPH | Metabolite | hmdb:HMDB0000221 | Nicotinamide adenine dinucleotide phosphate-Reduced |
Manganese | Metabolite | hmdb:HMDB0001333 | |
Folic acid | Metabolite | hmdb:HMDB0000121 | Synthetic folate |
RNS | Metabolite | chebi:62764 | reactive nitrogen specieshttp://en.wikipedia.org/wiki/Reactive_nitrogen_species |
Homocysteine | Metabolite | hmdb:HMDB0000742 | |
Pyridoxal 5'-phosphate | Metabolite | hmdb:HMDB0001491 | |
Pyridoxal 5'-phosphate | Metabolite | hmdb:HMDB0001491 | Vitamin B6 |
Glycine | Metabolite | hmdb:HMDB0000123 | |
L-Arginine | Metabolite | hmdb:HMDB0000517 | |
Serine | Metabolite | hmdb:HMDB0000187 | |
LDL | Metabolite | chebi:39026 | low-density lipoprotein |
HDL/APOA1 | Metabolite | chebi:39025 | high-density lipoproteinApoA-I is present on the majority of HDL particles and constitutes aprox 70% of the apolipoprotein content of HDL particles |
TAG | Metabolite | chebi:17855 | TriglycerideTriacylglycerol |
Cholesterol | Metabolite | hmdb:HMDB0000067 | |
HDL/SAA | Metabolite | chebi:39025 | high-density lipoproteinSAA circulates in plasma as a constituent of high density lipoproteins (HDL). |
HDL | Metabolite | chebi:39025 | high-density lipoprotein |
oxLDL | Metabolite | chebi:60151 | oxidized low-density lipoprotein |
VLDL | Metabolite | chebi:39027 | very-low-density lipoprotein |
FMN | Metabolite | hmdb:HMDB0001520 | Flavin Mononucleotide |
HDL-C | Metabolite | chebi:47775 | high-density lipoprotein cholesterolCholesterol transport |
VLDL-TAG | Metabolite | chebi:47776 | very-low-density lipoprotein-triglycerideTriglyceride transport |
VLDL/APOB | Metabolite | chebi:39027 | very-low-density lipoproteinThe VLDL is produced in the liver, contains one molecule of apoB100 |
O2 | Metabolite | hmdb:HMDB0001377 | |
Cob(I)alamin | Metabolite | hmdb:HMDB0002174 | Reduced cobalamin |
FAD | Metabolite | hmdb:HMDB0001248 | Flavin adenine dinucleotide |
8-OHdG | Metabolite | hmdb:HMDB0003333 | 8-Hydroxy-deoxyguanosine |
Cob(II)alamin | Metabolite | hmdb:HMDB0002174 | oxidized cobalamin |
ADP | Metabolite | hmdb:HMDB0001341 | Adenosine diphosphate |
Magnesium | Metabolite | hmdb:HMDB0000547 | |
Chlorine | Metabolite | hmdb:HMDB0000492 | |
S-nitrosohomocysteine | Metabolite | pubchem.compound:3035701 | |
Cystathionine | Metabolite | hmdb:HMDB0000099 | |
ATP | Metabolite | hmdb:HMDB0000538 | Adenosine triphosphate |
Zinc | Metabolite | hmdb:HMDB0015532 | |
NO | Metabolite | hmdb:HMDB0003378 | Nitric oxide |
HOCl | Metabolite | hmdb:HMDB0001050 | Hypochlorite |
O3 | Metabolite | chebi:25812 | ozone |
NO2 | Metabolite | chebi:33101 | Nitrogen dioxide |
HNO2 | Metabolite | chebi:25567 | Nitrous acid |
Fibrin | Metabolite | wikidata:Q27205 | |
Riboflavin | Metabolite | hmdb:HMDB0000244 | |
O2 | Metabolite | hmdb:HMDB0002168 | Superoxide |
S-Adenosylmethionine | Metabolite | hmdb:HMDB0001185 | |
Methionine | Metabolite | hmdb:HMDB0000696 | |
S-Adenosylhomocysteine | Metabolite | hmdb:HMDB0000939 | |
ONOO/ONOOH | Metabolite | hmdb:HMDB0002179 | Peroxynitrite |
Nitrotyrosine | Metabolite | hmdb:HMDB0001904 | |
Tetrahydrobiopterin | Metabolite | hmdb:HMDB0000027 | H4B |
Glucose | Metabolite | hmdb:HMDB0000122 | |
Fructosamine | Metabolite | hmdb:HMDB0002030 | |
Iron | Metabolite | hmdb:HMDB0000692 | |
NFKB1 | GeneProduct | ncbigene:4790 | nuclear factor NF-kappa-B p50 subunit |
FOLR1 | GeneProduct | ncbigene:2348 | folate receptor 1 (adult) |
RELA | GeneProduct | ncbigene:5970 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 |
MCP1 | GeneProduct | ncbigene:6347 | Monocyte Chemotactic Protein 1CCL2 |
p53 | GeneProduct | ncbigene:7157 | tumor protein p53 |
FOLR4 | GeneProduct | ncbigene:390243 | folate receptor 4 (delta) homolog (mouse) |
FOLR3 | GeneProduct | ncbigene:2352 | folate receptor 3 (gamma) |
SLC19A1 | GeneProduct | ncbigene:6573 | solute carrier family 19 (folate transporter), member 1 |
NFKB2 | GeneProduct | ncbigene:4791 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 |
FOLR2 | GeneProduct | ncbigene:2350 | folate receptor 2 (fetal) |
SLC46A1 | GeneProduct | ncbigene:113235 | solute carrier family 46 (folate transporter), member 1 |
MTHFD2 | Protein | ncbigene:10797 | EC 3.5.4.9methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase |
MSR* | Protein | ncbigene:4552 | EC 1.16.1.85-methyltetrahydrofolate-homocysteine methyltransferase reductase |
MAT | Protein | ncbigene:4143 | EC 2.5.1.6Methionine adenosyltransferase |
MTHFD1* | Protein | ncbigene:4522 | EC 1.5.1.5methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 |
MTR* | Protein | ncbigene:4548 | EC 2.1.1.135-methyltetrahydrofolate-homocysteine methyltransferaseAlso known as MS |
AHCY | Protein | ncbigene:191 | EC 3.3.1.1Adenosylhomocysteinase |
SHMT | Protein | ncbigene:6472 | EC 2.1.2.1Serine hydroxymethyltransferase |
DHFR | Protein | ncbigene:1719 | EC 1.5.1.3Dihydrofolate reductase |
CBS | Protein | ncbigene:875 | EC 4.2.1.22cystathionine-beta-synthase |
MPO | Protein | ncbigene:4353 | EC 1.11.1.7Myeloperoxidase |
NOS | Protein | uniprot:C9J5P6 | Nitric oxide synthase |
Catalase | Protein | ncbigene:847 | EC 1.11.1.6 |
tPA | Protein | ncbigene:5327 | EC 3.4.21.68plasminogen activator, tissue |
Factor VII | Protein | ncbigene:2155 | EC 3.4.21.21coagulation factor VII (serum prothrombin conversion accelerator) |
PLG | Protein | ncbigene:5340 | EC 3.4.21.7Plasminogen |
Thrombin | Protein | ncbigene:2147 | EC 3.4.21.5coagulation factor II (thrombin) |
PAI-1 | Protein | ncbigene:5054 | Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
GPX 4 | Protein | ncbigene:2879 | EC 1.11.1.12Selenoprotein-glutathione peroxidase 4 |
SOD3 | Protein | ncbigene:6649 | EC 1.15.1.1superoxide dismutase 3, extracellular |
RFK | Protein | ncbigene:55312 | EC 2.7.1.26riboflavin kinase |
GPX 3 | Protein | ncbigene:2878 | EC 1.11.1.9Selenoprotein-glutathione peroxidase 3 |
CTH | Protein | ncbigene:1491 | EC 4.4.1.1cystathionase |
GPX 6 | Protein | ncbigene:257202 | EC 1.11.1.9Selenoprotein-glutathione peroxidase 6 |
GPX 2 | Protein | ncbigene:2877 | EC 1.11.1.9Selenoprotein-glutathione peroxidase 2 |
GPX 1 | Protein | ncbigene:2876 | EC 1.11.1.9Selenoprotein-glutathione peroxidase 1 |
MTHFR* | Protein | ncbigene:4524 | EC 1.5.1.205,10-methylenetetrahydrofolate reductaseHomozygous of (MTHFR) 677C-T variant may have enzyme activities up to 50% lower than those without the polymorphism increasing the risk of hyperhomocysteinemia |
GART | Protein | ncbigene:2618 | EC 2.1.2.2phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase |
MTHFS | Protein | ncbigene:10588 | EC 6.3.3.25,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) |
SHMT | Protein | ncbigene:6470 | EC 2.1.2.1Serine hydroxymethyltransferase 1 (soluble) |
SOD1 | Protein | ncbigene:6647 | EC 1.15.1.1superoxide dismutase 1, soluble |
ACT | Protein | ncbigene:12 | alpha-1-antichymotrypsinserpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 |
APOB | Protein | ncbigene:338 | apolipoprotein B |
APOA1 | Protein | ncbigene:335 | apolipoprotein A-I |
SAA1 | Protein | ncbigene:6288 | serum amyloid A1 |
ABCA1 | Protein | ncbigene:19 | ATP-binding cassette, sub-family A (ABC1), member 1 |
SAA4 | Protein | ncbigene:6291 | serum amyloid A4, constitutive |
SAA2 | Protein | ncbigene:6289 | serum amyloid A2 |
SRB1 | Protein | ncbigene:949 | scavenger receptor class B, member 1 |
SAA3 | Protein | ncbigene:6290 | serum amyloid A3 pseudogene |
APOA1-NO2Tyr | Protein | ncbigene:335 | Nitrotyrosinated apolipoprotein A-I |
LDLR | Protein | ncbigene:3949 | low density lipoprotein receptor |
SOD2 | Protein | ncbigene:6648 | EC 1.15.1.1superoxide dismutase 2, mitochondrial |
IL1B | Protein | ncbigene:3553 | interleukin 1, beta |
IL2 | Protein | ncbigene:3558 | interleukin 2 |
Fibrinogen | Protein | wikidata:Q381899 | |
CRP | Protein | ncbigene:1401 | C-reactive protein, pentraxin-related |
HBB | Protein | ncbigene:3043 | hemoglobin, beta |
INSR | Protein | ncbigene:3643 | Insulin receptor |
HBA1 | Protein | ncbigene:3039 | hemoglobin, alpha 1 |
Fibrin | Protein | wikidata:Q27205 | |
IL10 | Protein | ncbigene:3458 | interferon, gamma |
HbA1c | Protein | wikidata:Q311213 | Glycated hemoglobinhttp://en.wikipedia.org/wiki/Glycated_hemoglobin |
IL4 | Protein | ncbigene:3565 | interleukin 4 |
CSF1 | Protein | ncbigene:1435 | colony stimulating factor 1 (macrophage) |
ALB | Protein | ncbigene:213 | albumin |
D-dimer | Protein | wikidata:Q2162109 | http://en.wikipedia.org/wiki/Fibrin_degradation_product |
INS | Protein | ncbigene:3630 | Insulin |
IFNg | Protein | ncbigene:3458 | interferon, gamma |
sICAM-1 | Protein | ncbigene:3383 | soluble intercellular adhesion molecule 1 |
TNFa | Protein | ncbigene:7124 | tumor necrosis factor (TNF superfamily, member 2) |
IL6 | Protein | ncbigene:3569 | interleukin 6 (interferon, beta 2) |
FLAD1 | Protein | ncbigene:80308 | EC 2.7.7.2FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae) |
FGA | Protein | ensembl:ENSG00000171560 | |
FGB | Protein | ensembl:ENSG00000171564 | |
FGG | Protein | ensembl:ENSG00000171557 |
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