PI3K-Akt signaling (WP4172)

Homo sapiens

Authors

Kristina Hanspers , Anders Riutta , Egon Willighagen , and Eric Weitz

Activity

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

• A Novel Based-Network Strategy to Identify Phytochemicals from Radix Salviae Miltiorrhizae (Danshen) for Treating Alzheimer’s Disease (2022).
• Tumour Stem Cells in Breast Cancer (2022).
• Transcriptome Signature of Immune Cells Post Reovirus Treatment in KRAS Mutated Colorectal Cancer (2021).
• Assessing the Contribution of Relative Macrophage Frequencies to Subcutaneous Adipose Tissue (2021).
• Predictive models for stage and risk classification in head and neck squamous cell carcinoma (HNSCC) (2020).
• A patient-based iPSC-derived hepatocyte model of alcohol-associated cirrhosis reveals bioenergetic insights into disease pathogenesis (2024).
• Non-dialyzable uremic toxins and renal tubular cell damage in CKD patients: a systems biology approach (2024).
• A Practical Strategy for Exploring the Pharmacological Mechanism of Luteolin Against COVID-19/Asthma Comorbidity: Findings of System Pharmacology and Bioinformatics Analysis (2024).
• Transcriptome analysis of newly established carboplatin-resistant ovarian cancer cell model reveals genes shared by drug resistance and drug-induced EMT (2023).
• Autistic spectrum disorder (ASD) - Gene, molecular and pathway signatures linking systemic inflammation, mitochondrial dysfunction, transsynaptic signalling, and neurodevelopmen (2023).

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

cancer pathway phosphatidylinositol 3-kinase signaling pathway phosphatidylinositol 3-kinase signaling pathway signaling pathway mTOR signaling pathway mTOR signaling pathway cell cycle pathway signaling pathway cell adhesion signaling pathway

Disease Ontology

cancer

References

1. Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha. Walker KS, Deak M, Paterson A, Hudson K, Cohen P, Alessi DR. Biochem J. 1998 Apr 1;331 ( Pt 1)(Pt 1):299–308. PubMed Europe PMC Scholia
2. Structure and function of phosphoinositide 3-kinases. Wymann MP, Pirola L. Biochim Biophys Acta. 1998 Dec 8;1436(1–2):127–50. PubMed Europe PMC Scholia
3. Oncogenic kinase signalling. Blume-Jensen P, Hunter T. Nature. 2001 May 17;411(6835):355–65. PubMed Europe PMC Scholia
4. Regulation of Raf-Akt Cross-talk. Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M. J Biol Chem. 2002 Aug 23;277(34):31099–106. PubMed Europe PMC Scholia
5. Activation of the PI3K/Akt pathway and chemotherapeutic resistance. West KA, Castillo SS, Dennis PA. Drug Resist Updat. 2002 Dec;5(6):234–48. PubMed Europe PMC Scholia
6. The role of PI3K in immune cells. Koyasu S. Nat Immunol. 2003 Apr;4(4):313–9. PubMed Europe PMC Scholia
7. PI3K in lymphocyte development, differentiation and activation. Okkenhaug K, Vanhaesebroeck B. Nat Rev Immunol. 2003 Apr;3(4):317–30. PubMed Europe PMC Scholia
8. PI3-kinase and TOR: PIKTORing cell growth. Richardson CJ, Schalm SS, Blenis J. Semin Cell Dev Biol. 2004 Apr;15(2):147–59. PubMed Europe PMC Scholia
9. PI3K-Akt pathway: its functions and alterations in human cancer. Osaki M, Oshimura M, Ito H. Apoptosis. 2004 Nov;9(6):667–76. PubMed Europe PMC Scholia
10. The activation of Akt/PKB signaling pathway and cell survival. Song G, Ouyang G, Bao S. J Cell Mol Med. 2005;9(1):59–71. PubMed Europe PMC Scholia
11. “New”-clear functions of PDK1: beyond a master kinase in the cytosol? Kikani CK, Dong LQ, Liu F. J Cell Biochem. 2005 Dec 15;96(6):1157–62. PubMed Europe PMC Scholia
12. Akt: versatile mediator of cell survival and beyond. Kim D, Chung J. J Biochem Mol Biol. 2002 Jan 31;35(1):106–15. PubMed Europe PMC Scholia
13. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Engelman JA, Luo J, Cantley LC. Nat Rev Genet. 2006 Aug;7(8):606–19. PubMed Europe PMC Scholia
14. Proto-oncogene TCL1: more than just a coactivator for Akt. Noguchi M, Ropars V, Roumestand C, Suizu F. FASEB J. 2007 Aug;21(10):2273–84. PubMed Europe PMC Scholia
15. The life of a cell: apoptosis regulation by the PI3K/PKB pathway. Duronio V. Biochem J. 2008 Nov 1;415(3):333–44. PubMed Europe PMC Scholia
16. Cell signaling by receptor tyrosine kinases. Lemmon MA, Schlessinger J. Cell. 2010 Jun 25;141(7):1117–34. PubMed Europe PMC Scholia
17. Akt, FoxO and regulation of apoptosis. Zhang X, Tang N, Hadden TJ, Rishi AK. Biochim Biophys Acta. 2011 Nov;1813(11):1978–86. PubMed Europe PMC Scholia
18. Akt signalling in health and disease. Hers I, Vincent EE, Tavaré JM. Cell Signal. 2011 Oct;23(10):1515–27. PubMed Europe PMC Scholia
19. PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control. Georgescu MM. Genes Cancer. 2010 Dec;1(12):1170–7. PubMed Europe PMC Scholia
20. The neurotrophin family of neurotrophic factors: an overview. Skaper SD. Methods Mol Biol. 2012;846:1–12. PubMed Europe PMC Scholia
21. PhosphoSitePlus, 2014: mutations, PTMs and recalibrations. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E. Nucleic Acids Res. 2015 Jan;43(Database issue):D512-20. PubMed Europe PMC Scholia