p53 transcriptional gene network (WP4963)

Homo sapiens

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The mechanisms underlying p53 tumor-suppressor function as gleaned from mouse models of genetic disruption to p53, its regulators and its targets (Kaiser 2017).

Authors

Xin Ding , Ernesto Diaz-Flores , Egon Willighagen , Alex Pico , Kristina Hanspers , and Julia Johnsson

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

p53 signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
RPTOR GeneProduct ensembl:ENSG00000141564
MIR34A GeneProduct ensembl:ENSG00000284357
AKT1S1 GeneProduct ensembl:ENSG00000204673
E2F7 GeneProduct ensembl:ENSG00000165891
PRKAA2 GeneProduct ensembl:ENSG00000162409
APAF1 GeneProduct ensembl:ENSG00000120868
SFN GeneProduct ensembl:ENSG00000175793
MTOR GeneProduct ensembl:ENSG00000198793
CDK2 GeneProduct ensembl:ENSG00000123374
FASLG GeneProduct ensembl:ENSG00000117560
PCNA GeneProduct ensembl:ENSG00000132646
TP53I3 GeneProduct ensembl:ENSG00000115129
TP53I3 GeneProduct ensembl:ENSG00000115129
AURKA GeneProduct ensembl:ENSG00000087586
SCO2 GeneProduct ensembl:ENSG00000284194
PRKAG3 GeneProduct ensembl:ENSG00000115592
DDIT4 GeneProduct ensembl:ENSG00000168209
TP53I3 GeneProduct ensembl:ENSG00000115129
MLST8 GeneProduct ensembl:ENSG00000167965
TNFRSF10B GeneProduct ensembl:ENSG00000120889
PRKAA1 GeneProduct ensembl:ENSG00000132356
PRKAG2 GeneProduct ensembl:ENSG00000106617
TNF GeneProduct ensembl:ENSG00000232810
CDC25C GeneProduct ensembl:ENSG00000158402
MIR34A GeneProduct ensembl:ENSG00000284357
DEPTOR GeneProduct ensembl:ENSG00000155792
CCNE1 GeneProduct ensembl:ENSG00000105173
PRKAG1 GeneProduct ensembl:ENSG00000181929
TSC2 GeneProduct ensembl:ENSG00000103197
MIR34C GeneProduct ensembl:ENSG00000207562
BAX GeneProduct ensembl:ENSG00000087088
FAS GeneProduct ensembl:ENSG00000026103
MIR34A GeneProduct ensembl:ENSG00000284357
PMAIP1 GeneProduct ensembl:ENSG00000141682
TP53AIP1 GeneProduct ensembl:ENSG00000120471
TRAF4 GeneProduct ensembl:ENSG00000076604
PERP GeneProduct ensembl:ENSG00000112378
PIDD1 GeneProduct ensembl:ENSG00000177595
TP53I3 GeneProduct ensembl:ENSG00000115129
BBC3 GeneProduct ensembl:ENSG00000105327
SIVA1 GeneProduct ensembl:ENSG00000184990
TNFRSF10D GeneProduct ensembl:ENSG00000173530
YWHAB-208 GeneProduct ensembl:ENST00000633979
BTG2 GeneProduct ensembl:ENSG00000159388
CCNG1 GeneProduct ensembl:ENSG00000113328
CDKN1A GeneProduct ensembl:ENSG00000124762
GADD45A GeneProduct ensembl:ENSG00000116717
MIR34A GeneProduct ensembl:ENSG00000284357
MIR34B GeneProduct ensembl:ENSG00000207811
SMR3B GeneProduct ensembl:ENSG00000171201
RPRM GeneProduct ensembl:ENSG00000177519
ZMAT3 GeneProduct ensembl:ENSG00000172667
CDKN1A GeneProduct ensembl:ENSG00000124762
SERPINE1 GeneProduct ensembl:ENSG00000106366
PML GeneProduct ensembl:ENSG00000140464
DDB2 GeneProduct ensembl:ENSG00000134574
ERCC5 GeneProduct ensembl:ENSG00000134899
FANCC GeneProduct ensembl:ENSG00000158169
GADD45A GeneProduct ensembl:ENSG00000116717
XRCC5 GeneProduct ensembl:ENSG00000079246
MGMT GeneProduct ensembl:ENSG00000170430
MLH1 GeneProduct ensembl:ENSG00000076242
MSH2 GeneProduct ensembl:ENSG00000095002
POLH GeneProduct ensembl:ENSG00000170734
POLK GeneProduct ensembl:ENSG00000122008
RRM2B GeneProduct ensembl:ENSG00000048392
XPC GeneProduct ensembl:ENSG00000154767
SAT1 GeneProduct ensembl:ENSG00000130066
SLC7A11 GeneProduct ensembl:ENSG00000151012
GLS2 GeneProduct ensembl:ENSG00000135423
CDKN1A GeneProduct ensembl:ENSG00000124762
MIR34A GeneProduct ensembl:ENSG00000284357
MIR200C GeneProduct ensembl:ENSG00000207713
SERPINB5 GeneProduct ensembl:ENSG00000206075
CDKN1A GeneProduct ensembl:ENSG00000124762
LIF GeneProduct ensembl:ENSG00000128342
MIR34A GeneProduct ensembl:ENSG00000284357
MIR34B GeneProduct ensembl:ENSG00000207811
MIR34C GeneProduct ensembl:ENSG00000207562
MIR145 GeneProduct ensembl:ENSG00000276365
NANOG GeneProduct ensembl:ENSG00000111704
NOTCH1 GeneProduct ensembl:ENSG00000148400
ACAD11 GeneProduct ensembl:ENSG00000240303
ADORA2B GeneProduct ensembl:ENSG00000170425
ALDH4A1 GeneProduct ensembl:ENSG00000159423
CPT1C GeneProduct ensembl:ENSG00000169169
DRAM1 GeneProduct ensembl:ENSG00000136048
FUCA1 GeneProduct ensembl:ENSG00000179163
GLS2 GeneProduct ensembl:ENSG00000135423
SLC2A1 GeneProduct ensembl:ENSG00000117394
GPX1 GeneProduct ensembl:ENSG00000233276
PRKAB1 GeneProduct ensembl:ENSG00000111725
PRKAB2 GeneProduct ensembl:ENSG00000131791
PTEN GeneProduct ensembl:ENSG00000171862
SESN1 GeneProduct ensembl:ENSG00000080546
SESN2 GeneProduct ensembl:ENSG00000130766
TIGAR GeneProduct ensembl:ENSG00000078237
TP53INP1 GeneProduct ensembl:ENSG00000164938 mouse ortholog: Trp53inp1
ULK1 GeneProduct ensembl:ENSG00000177169
ULK2 GeneProduct ensembl:ENSG00000083290
ADGRB1 GeneProduct ensembl:ENSG00000181790
CX3CL1 GeneProduct ensembl:ENSG00000006210
ICAM1 GeneProduct ensembl:ENSG00000090339
IRF5 GeneProduct ensembl:ENSG00000128604
IRF9 GeneProduct ensembl:ENSG00000213928
ISG15 GeneProduct ensembl:ENSG00000187608
SERPINB5 GeneProduct ensembl:ENSG00000206075
CCL2 GeneProduct ensembl:ENSG00000108691
NCF2 GeneProduct ensembl:ENSG00000116701
SERPINE1 GeneProduct ensembl:ENSG00000106366
THBS1 GeneProduct ensembl:ENSG00000137801
ULBP1 GeneProduct ensembl:ENSG00000111981
ULBP2 GeneProduct ensembl:ENSG00000131015
MIR34C GeneProduct ensembl:ENSG00000207562
CDC25A Protein uniprot:C9JH94

References

  1. Deconstructing networks of p53-mediated tumor suppression in vivo. Kaiser AM, Attardi LD. Cell Death Differ. 2018 Jan;25(1):93–103. PubMed Europe PMC Scholia
  2. p53: 800 million years of evolution and 40 years of discovery. Levine AJ. Nat Rev Cancer. 2020 Aug;20(8):471–80. PubMed Europe PMC Scholia
  3. Tumor suppressor p53: Biology, signaling pathways, and therapeutic targeting. Hernández Borrero LJ, El-Deiry WS. Biochim Biophys Acta Rev Cancer. 2021 Aug;1876(1):188556. PubMed Europe PMC Scholia