ACE inhibitor pathway (WP1033)

Bos taurus

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The core of this pathway was elucidated over a century ago and involves the conversion of angiotensinogen to angiotensin I (Ang I) by renin, its subsequent conversion to angiotensin II (Ang II) by angiotensin converting enzyme. Ang II activates the angiotensin II receptor type 1 to induce aldosterone synthesis, increasing water and salt resorption and potassium excretion in the kidney and increasing blood pressure. Source: PharmGKB (http://www.pharmgkb.org/do/serve?objId=PA2023&objCls=Pathway)

Authors

Thomas Kelder , Egon Willighagen , Christine Chichester , Kristina Hanspers , Martina Summer-Kutmon , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Bos taurus

Communities

Renal Genomics Pathways

Annotations

Pathway Ontology

angiotensin signaling pathway ACE inhibitor drug pathway

Participants

Label Type Compact URI Comment
Ang 1-5 Metabolite kegg.compound:C15852
Aldosterone Metabolite hmdb:HMDB0000037
Bradykinin Metabolite hmdb:HMDB0004246
Angiotensin II Metabolite hmdb:HMDB0001035
Ca++ Metabolite hmdb:HMDB0000464
Angiotensin I Metabolite pubchem.compound:3081372
ACE Inhibitor Metabolite chebi:35457
Deoxycorticosterone Metabolite hmdb:HMDB0000016
Ang 1-7 Metabolite chemspider:110354
Prostacyclin Metabolite pubchem.compound:114805
Ang 1-9 Metabolite kegg.compound:C15851
NOS3 GeneProduct ensembl:ENSBTAG00000017680 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4846
AGTR2 GeneProduct ensembl:ENSBTAG00000040386 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:186
BDKRB1 GeneProduct ensembl:ENSBTAG00000007052 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:623
AGTR1 GeneProduct ensembl:ENSBTAG00000045633 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:185
TGFB1 GeneProduct ensembl:ENSBTAG00000020457 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7040
CTSG GeneProduct ensembl:ENSBTAG00000013234 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1511
KNG1 GeneProduct ensembl:ENSBTAG00000005122 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3827
ACE GeneProduct ensembl:ENSBTAG00000024950 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1636
CMA1 GeneProduct ensembl:ENSBTAG00000027033 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1215
REN GeneProduct ensembl:ENSBTAG00000021333 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5972
CYP11B2 GeneProduct ensembl:ENSBTAG00000037824 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1585
MAS1 GeneProduct ensembl:ENSBTAG00000031724 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4142
ACE2 GeneProduct ensembl:ENSBTAG00000034402 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:59272
AGT GeneProduct ensembl:ENSBTAG00000012393 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:183
NR3C2 GeneProduct ensembl:ENSBTAG00000027182 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4306
ATP6AP2 GeneProduct ensembl:ENSBTAG00000017801 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10159
BDKRB2 GeneProduct ensembl:ENSBTAG00000021717 Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:624

References

  1. The regulation of aldosterone synthase expression. Bassett MH, White PC, Rainey WE. Mol Cell Endocrinol. 2004 Mar 31;217(1–2):67–74. PubMed Europe PMC Scholia
  2. Pharmacogenetics of antihypertensive drug responses. Schwartz GL, Turner ST. Am J Pharmacogenomics. 2004;4(3):151–60. PubMed Europe PMC Scholia
  3. Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms. Huang Y, Wongamorntham S, Kasting J, McQuillan D, Owens RT, Yu L, et al. Kidney Int. 2006 Jan;69(1):105–13. PubMed Europe PMC Scholia
  4. The emerging role of ACE2 in physiology and disease. Hamming I, Cooper ME, Haagmans BL, Hooper NM, Korstanje R, Osterhaus ADME, et al. J Pathol. 2007 May;212(1):1–11. PubMed Europe PMC Scholia
  5. Effects of renin-angiotensin system inhibition on end-organ protection: can we do better? Weir MR. Clin Ther. 2007 Sep;29(9):1803–24. PubMed Europe PMC Scholia
  6. The (pro)renin receptor: a new addition to the renin-angiotensin system? Batenburg WW, Jan Danser AH. Eur J Pharmacol. 2008 May 13;585(2–3):320–4. PubMed Europe PMC Scholia
  7. Are we poised to target ACE2 for the next generation of antihypertensives? Ferreira AJ, Raizada MK. J Mol Med (Berl). 2008 Jun;86(6):685–90. PubMed Europe PMC Scholia
  8. Mineralocorticoid receptor antagonists and endothelial function. Maron BA, Leopold JA. Curr Opin Investig Drugs. 2008 Sep;9(9):963–9. PubMed Europe PMC Scholia