Hallmark of cancer: sustaining proliferative signaling (WP5475)

Homo sapiens

Proliferative signalling in cancer cells

Authors

PhilipErnst , Eric Weitz , and Kristina Hanspers

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

cancer pathway signaling pathway

Participants

Label Type Compact URI Comment
PIP3 Metabolite chebi:16618
GDP Metabolite chebi:17552
PIP2 Metabolite chebi:18348
GTP Metabolite chebi:37565
Phosphate Metabolite hmdb:HMDB0001429
GTP Metabolite chebi:15996
RAF GeneProduct ensembl:ENSG00000132155
RAS GeneProduct ensembl:ENSG00000174775
GRB2 GeneProduct ensembl:ENSG00000177885
TSC1 GeneProduct ensembl:ENSG00000165699
SHC GeneProduct ensembl:ENSG00000160691
ULK2 GeneProduct ensembl:ENSG00000083290
FOXO1 GeneProduct ensembl:ENSG00000150907
ERK1 GeneProduct ensembl:ENSG00000102882
FAK GeneProduct ensembl:ENSG00000169398
RHEB GeneProduct ensembl:ENSG00000106615
MAP2K1 GeneProduct ensembl:ENSG00000169032
TSC2 GeneProduct ensembl:ENSG00000103197
SRC GeneProduct ensembl:ENSG00000197122
PTEN GeneProduct ensembl:ENSG00000171862
SOS GeneProduct ensembl:ENSG00000115904
PIK3CA GeneProduct ensembl:ENSG00000121879
PIK3CB GeneProduct ensembl:ENSG00000051382
PIK3CD GeneProduct ensembl:ENSG00000171608
PIK3CG GeneProduct ensembl:ENSG00000105851
ERK2 GeneProduct ensembl:ENSG00000100030
MAP2K2 GeneProduct ensembl:ENSG00000126934
PRAS40 GeneProduct ensembl:ENSG00000204673
TEL2 GeneProduct ensembl:ENSG00000100726
TTI1 GeneProduct ensembl:ENSG00000101407
MLST8 GeneProduct ensembl:ENSG00000167965
DEPTOR GeneProduct ensembl:ENSG00000155792
MTOR GeneProduct ensembl:ENSG00000198793
RPTOR GeneProduct ensembl:ENSG00000141564
MDM2 GeneProduct ensembl:ENSG00000135679
P21 GeneProduct ensembl:ENSG00000124762
FGFR2 GeneProduct ensembl:ENSG00000066468
KDR GeneProduct ensembl:ENSG00000128052
INSR GeneProduct ensembl:ENSG00000171105
FGFR3 GeneProduct ensembl:ENSG00000068078
IGF1R GeneProduct ensembl:ENSG00000140443
KIT GeneProduct ensembl:ENSG00000157404
FGFR1 GeneProduct ensembl:ENSG00000077782
EPHA2 GeneProduct ensembl:ENSG00000142627
EGFR GeneProduct ensembl:ENSG00000146648
CSF1R GeneProduct ensembl:ENSG00000182578
FGFR4 GeneProduct ensembl:ENSG00000160867
FLT1 GeneProduct ensembl:ENSG00000102755
FLT4 GeneProduct ensembl:ENSG00000037280
NGFR GeneProduct ensembl:ENSG00000064300
MET GeneProduct ensembl:ENSG00000105976
PDGFRA GeneProduct ensembl:ENSG00000134853
PDGFRB GeneProduct ensembl:ENSG00000113721
TEK GeneProduct ensembl:ENSG00000120156
FLT3 GeneProduct ensembl:ENSG00000122025
NTRK1 GeneProduct ensembl:ENSG00000198400
NTRK2 GeneProduct ensembl:ENSG00000148053 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687
IL6 GeneProduct ncbigene:3569
AKT2 GeneProduct ncbigene:208
STAT3 GeneProduct ncbigene:6774
AKT3 GeneProduct ncbigene:10000
AKT1 GeneProduct ncbigene:207
IL6R GeneProduct ncbigene:3570
JAK2 GeneProduct ncbigene:3717
RELA GeneProduct ensembl:ENSG00000173039 RelA
NFKBIA GeneProduct ensembl:ENSG00000100906
REL GeneProduct ensembl:ENSG00000162924 c-Rel
NFKB1 GeneProduct ensembl:ENSG00000109320
NFKBIE GeneProduct ensembl:ENSG00000146232
CHUK GeneProduct ensembl:ENSG00000213341 IKKa
IKBKB GeneProduct ensembl:ENSG00000104365
IKBKG GeneProduct ensembl:ENSG00000269335 IKKy
c-MYC GeneProduct ensembl:ENSG00000136997
AML1 GeneProduct ensembl:LRG_482
TCF GeneProduct ensembl:ENSG00000071564 TCF Not Specified
LEF GeneProduct ensembl:ENSG00000138795 LEF Not Specified
PPARD GeneProduct ensembl:ENSG00000112033
GSK3B GeneProduct ensembl:ENSG00000082701
WNT GeneProduct ensembl:ENSG00000125084 Wnt Not Specified
RARA GeneProduct ensembl:ENSG00000131759
PLZF GeneProduct ensembl:ENSG00000109906
BCL9 GeneProduct ensembl:ENSG00000116128
RUNX1T1 GeneProduct ensembl:ENSG00000079102
PML GeneProduct ensembl:ENSG00000140464
LRP6 GeneProduct ensembl:ENSG00000070018
APC GeneProduct ensembl:ENSG00000134982
CK1 GeneProduct ensembl:ENSG00000113712
LRP5 GeneProduct ensembl:ENSG00000162337
AXIN GeneProduct ensembl:ENSG00000168646
SALL4 GeneProduct ensembl:ENSG00000101115
PYGO GeneProduct ensembl:ENSG00000171016 PYGO Not Specified
KSR1 GeneProduct ensembl:ENSG00000141068
ELK1 GeneProduct ensembl:ENSG00000126767
c-FOS GeneProduct ensembl:ENSG00000170345
c-JUN GeneProduct ensembl:ENSG00000177606
CRAF GeneProduct ensembl:ENSG00000132155
SOS2 GeneProduct ensembl:ENSG00000100485
MAPK3 GeneProduct ensembl:ENSG00000102882 Also known as ERK
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MAPK3 GeneProduct ensembl:ENSG00000102882 Also known as ERK
SHC1 GeneProduct ensembl:ENSG00000160691
BRAF GeneProduct ensembl:ENSG00000157764
SOS1 GeneProduct ensembl:ENSG00000115904
IL-11 Protein ena.embl:ENSG00000095752
TP53 Protein ensembl:ENSG00000141510
RETN Protein ensembl:ENSG00000104918
Junction plakoglobin Protein uniprot:P14923
Frizzled Protein uniprot:E5RGK8 Frizzled Not Specified
cyclin-D1 Protein uniprot:P24385
Catenin beta-1 Protein uniprot:B4DGU4
RAS Protein ensembl:ENSG00000133703 RAS protein has three isoforms ( K,N and H RAS). the isoforms differ in ability of activating RAF protein, the isoform which is responsable the most of activating of Raf protein is Kras> also, HRAS has the ability of activating the RAF proteins but less efficiently than KRAS. (PMID: 9727023)
GRB2 Protein uniprot:Q75VX8

References

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  4. Characterization of murine A-raf, a new oncogene related to the v-raf oncogene. Huleihel M, Goldsborough M, Cleveland J, Gunnell M, Bonner T, Rapp UR. Mol Cell Biol. 1986 Jul;6(7):2655–62. PubMed Europe PMC Scholia
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