Mechanisms associated with pluripotency (WP1763)

Mus musculus

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The aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we intentionally focused on information flow, neglecting reactions, metabolites, intracellular movement of components, and their modifications such as protein phosphorylation Each edge can be seen as direct mechanism between its nodes. For more information, see Som A, Harder C, Greber B, Siatkowski M, Paudel Y, et al. 2010 The PluriNetWork: An Electronic Representation of the Network Underlying Pluripotency in Mouse, and Its Applications. PLoS ONE 5(12): e15165. doi:10.1371/journal.pone.0015165 http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0015165 The June 2010 PluriNetWork described in the paper can be found at http://www.ibima.med.uni-rostock.de/IBIMA/PluriNetWork/ . The PluriNetWork at WikiPathWays started with the December 2010 version.

Authors

C.Harder , Alex Pico , Daniela Digles , Martina Summer-Kutmon , Chris Evelo , Eric Weitz , and Egon Willighagen

Activity

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

signaling pathway pertinent to development

Cell Type Ontology

pluripotent stem cell

Participants

Label Type Compact URI Comment
Smarcad1 GeneProduct ncbigene:13990 full name: SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
Crebbp GeneProduct ncbigene:12914 full name: CREB binding protein
Rel GeneProduct ncbigene:19696 full name: reticuloendotheliosis oncogene
Ctbp1 GeneProduct ncbigene:13016 full name: C-terminal binding protein 1
Tert GeneProduct ncbigene:21752 full name: telomerase reverse transcriptase
Cdkn2a GeneProduct ncbigene:12578 full name: cyclin-dependent kinase inhibitor 2A
Mdm2 GeneProduct ncbigene:17246 full name: transformed mouse 3T3 cell double minute 2
Cdkn1a GeneProduct ncbigene:12575 full name: cyclin-dependent kinase inhibitor 1A (P21)
Zfp143 GeneProduct ncbigene:20841 full name: zinc finger protein 143
Nr2f2 GeneProduct ncbigene:11819 full name: nuclear receptor subfamily 2, group F, member 2
Nr2f1 GeneProduct ncbigene:13865 full name: nuclear receptor subfamily 2, group F, member 1
Sp1 GeneProduct ncbigene:20683 full name: trans-acting transcription factor 1
Xist GeneProduct ncbigene:213742 full name: inactive X specific transcripts
Mpl GeneProduct ncbigene:17480 full name: myeloproliferative leukemia virus oncogene
Fgf4 GeneProduct ncbigene:14175 full name: fibroblast growth factor 4
Tcfcp2l1 GeneProduct ncbigene:81879 full name: transcription factor CP2-like 1
Mycn GeneProduct ncbigene:18109 full name: v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
Bmpr2 GeneProduct ncbigene:12168 full name: bone morphogenic protein receptor, type II (serine/threonine kinase)
Smad4 GeneProduct ncbigene:17128 full name: MAD homolog 4 (Drosophila)
Notch1 GeneProduct ncbigene:18128 full name: Notch gene homolog 1 (Drosophila)
Rras GeneProduct ncbigene:20130 full name: Harvey rat sarcoma oncogene, subgroup R
Wnt5a GeneProduct ncbigene:22418 full name: wingless-related MMTV integration site 5A
Pias2 GeneProduct ncbigene:17344 full name: protein inhibitor of activated STAT 2
Psen1 GeneProduct ncbigene:19164 full name: Presenilin 1
Tpo GeneProduct ncbigene:22018 full name: thyroid peroxidase
Dkk1 GeneProduct ncbigene:13380 full name: dickkopf homolog 1 (Xenopus laevis)
Cer1 GeneProduct ncbigene:12622 full name: cerberus 1 homolog (Xenopus laevis)
Nfkb1 GeneProduct ncbigene:18033 full name: nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105
Lefty1 GeneProduct ncbigene:13590 full name: left right determination factor 1
Ptprs GeneProduct ncbigene:19280 full name: protein tyrosine phosphatase, receptor type, S
Fbxo15 GeneProduct ncbigene:50764 full name: F-box protein 15
Cdk2ap1 GeneProduct ncbigene:13445 full name: CDK2 (cyclin-dependent kinase 2)-associated protein 1
Mbd2 GeneProduct ncbigene:17191 full name: methyl-CpG binding domain protein 2
Mbd3 GeneProduct ncbigene:17192 full name: methyl-CpG binding domain protein 3
Ep400 GeneProduct ncbigene:75560 full name: E1A binding protein p400
Ogt GeneProduct ncbigene:108155 full name: O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
Ube2i GeneProduct ncbigene:22196 full name: ubiquitin-conjugating enzyme E2I
Med12 GeneProduct ncbigene:59024 full name: mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)
Hdac2 GeneProduct ncbigene:15182 full name: Histone deacetylase 2
Trim28 GeneProduct ncbigene:21849 full name: Tripartitemotif-containing28
Yy1 GeneProduct ncbigene:22632 full name: YY1 transcription factor
Arid3b GeneProduct ncbigene:56380 full name: AT rich interactive domain 3B (BRIGHT-like)
Rnf2 GeneProduct ncbigene:19821 full name: ring finger protein 2
Nr5a2 GeneProduct ncbigene:26424 full name: nuclear receptor subfamily 5, group A, member 2
Tcf7 GeneProduct ncbigene:21414 full name: Transcription factor7 ,T-cell specific
Rcor2 GeneProduct ncbigene:104383 full name: REST corepressor 2
Cubn GeneProduct ncbigene:65969 full name: cubilin (intrinsic factor-cobalamin receptor)
Ercc5 GeneProduct ncbigene:22592 full name: excision repair cross-complementing rodent repair deficiency, complementation group 5
Gadd45a GeneProduct ncbigene:13197 full name: growth arrest and DNA-damage-inducible 45 alpha
Nr6a1 GeneProduct ncbigene:328572 full name: nuclear receptor subfamily 6, group A, member 1
Rif1 GeneProduct ncbigene:51869 full name: Rap1 interacting factor 1 homolog (yeast)
Zfp281 GeneProduct ncbigene:226442 full name: zinc finger protein 281
Nacc1 GeneProduct ncbigene:66830 full name: nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
Nr0b1 GeneProduct ncbigene:11614 full name: nuclear receptor subfamily 0, group B, member 1
Zfx GeneProduct ncbigene:22764 full name: zinc finger protein X-linked
Mybl2 GeneProduct ncbigene:17865 full name: myeloblastosis oncogene-like 2
Klf4 GeneProduct ncbigene:16600 full name: Kruppel-like factor 4 (gut)
Dhx9 GeneProduct ncbigene:13211 full name: DEAH (Asp-Glu-Ala-His) box polypeptide 9
Rest GeneProduct ncbigene:19712 full name: RE1-silencing transcription factor
Thap11 GeneProduct ncbigene:59016 full name: THAP domain containing 11
Hcfc1 GeneProduct ncbigene:15161 full name: host cell factor C1
Pou5f1 GeneProduct ncbigene:18999 full name: POU domain, class 5, transcription factor 1
Mapk3 GeneProduct ncbigene:26417 full name: mitogen-activated protein kinase 3
Tcl1 GeneProduct ncbigene:21432 full name: T-cell lymphoma breakpoint 1
Tbx3 GeneProduct ncbigene:21386 full name: T-box3
Id1 GeneProduct ncbigene:15901 full name: inhibitor of DNA binding 1
Gata6 GeneProduct ncbigene:14465 full name: GATA binding protein 6
Pou2f1 GeneProduct ncbigene:18986 full name: POU domain, class 2, transcription factor 1
P4ha1 GeneProduct ncbigene:18451 full name: procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide
Gab1 GeneProduct ncbigene:14388 full name: growth factor receptor bound protein 2-associated protein 1
Jak1 GeneProduct ncbigene:16451 full name: Janus kinase 1
Socs1 GeneProduct ncbigene:216233 full name: suppressorofcytokinesignaling2
Il6st GeneProduct ncbigene:16195 full name: interleukin 6 signal transducer
Lifr GeneProduct ncbigene:16880 full name: leukemia inhibitory factor receptor
Lif GeneProduct ncbigene:16878 full name: leukemia inhibitory factor
Apc GeneProduct ncbigene:11789 full name: adenomatosis polyposis coli
Axin1 GeneProduct ncbigene:12005 full name: Axin1
Lef1 GeneProduct ncbigene:16842 full name: lymphoid enhancer binding factor 1
Zic3 GeneProduct ncbigene:22773 full name: zinc finger protein of the cerebellum 3
Trim33 GeneProduct ncbigene:94093 full name: tripartite motif-containing 33
Frap1 GeneProduct ncbigene:56717 full name: FK506 binding protein 12-rapamycin associated protein 1
Akt1 GeneProduct ncbigene:11651 full name: thymoma viral proto-oncogene 1
Myc GeneProduct ncbigene:17869 full name: myelocytomatosis oncogene
Cdx2 GeneProduct ncbigene:12591 full name: caudal type homeo box 2
Ccnd1 GeneProduct ncbigene:12443 full name: cyclin D1
Stat3 GeneProduct ncbigene:20848 full name: signal transducer and activator of transcription 3
Sall4 GeneProduct ncbigene:99377 full name: sal-like 4 (Drosophila)
Foxd3 GeneProduct ncbigene:15221 full name: forkhead box D3
Nanog GeneProduct ncbigene:71950 full name: Nanog homeobox
Sox2 GeneProduct ncbigene:20674 full name: SRY-box containing gene 2
Ddb1 GeneProduct ncbigene:13194 full name: damage specific DNA binding protein 1
Trp53 GeneProduct ncbigene:22059 full name: transformation related protein 53
Eras GeneProduct ncbigene:353283 full name: ES cell-expressed Ras
Pten GeneProduct ncbigene:19211 full name: phosphatase and tensin homolog
Pik3cd GeneProduct ncbigene:18707 full name: phosphatidylinositol 3-kinase, catalytic delta polypeptide
Map2k1 GeneProduct ncbigene:26395 full name: mitogen-activated protein kinase kinase 1
Raf1 GeneProduct ncbigene:110157 full name: v-raf-leukemia viral oncogene 1
Hras1 GeneProduct ncbigene:15461 full name: Harvey rat sarcoma virus oncogene 1
Smad2 GeneProduct ncbigene:17126 full name: MAD homolog 2 (Drosophila)
Tgfbr1 GeneProduct ncbigene:21812 full name: transforming growth factor, beta receptor I / ALK5
Nodal GeneProduct ncbigene:18119 full name: Nodal homolog
Hnrnpu GeneProduct ncbigene:51810 full name: heterogeneous nuclear ribonucleoprotein U
Fgfr1 GeneProduct ncbigene:14182 full name: fibroblast growth factor receptor 1
Bmp4 GeneProduct ncbigene:12159 full name: bone morphogenetic protein 4
Acvr1 GeneProduct ncbigene:11477 full name: activin A receptor, type 1
Smad1 GeneProduct ncbigene:17125 full name: MAD homolog 1 (Drosophila)
Cdh1 GeneProduct ncbigene:12550 full name: cadherin 1
Ctnnb1 GeneProduct ncbigene:12387 full name: catenin (cadherin associated protein), beta 1
Tcf3 GeneProduct ncbigene:21415 full name: transcription factor 3
Itgb1 GeneProduct ncbigene:16412 full name: integrin beta 1 (fibronectin receptor beta)
Gsk3b GeneProduct ncbigene:56637 full name: glycogen synthase kinase 3 beta
Dvl1 GeneProduct ncbigene:13542 full name: dishevelled, dsh homolog 1 (Drosophila)
Hdac4 GeneProduct ncbigene:208727 full name: histone deacetylase 4
Phf17 GeneProduct ncbigene:269424 full name: PHD finger protein 17
Fzd1 GeneProduct ncbigene:14362 full name: frizzled homolog 1 (Drosophila)
Lrp5 GeneProduct ncbigene:16973 full name: low density lipoprotein receptor-related protein 5
Wnt3a GeneProduct ncbigene:22416 full name: wingless-related MMTV integration site 3A
Ptpn11 GeneProduct ncbigene:19247 full name: protein tyrosine phosphatase, non-receptor type 11
Grb2 GeneProduct ncbigene:14784 full name: growthfactorreceptor-boundprotein2
Zfp42 GeneProduct ncbigene:22702 full name: zinc finger protein 42
Ep300 GeneProduct ncbigene:328572 full name: E1A binding protein p300
Utf1 GeneProduct ncbigene:22286 full name: undifferentiated embryonic cell transcription factor 1
Esrrb GeneProduct ncbigene:26380 full name: estrogen related receptor, beta
Phc1 GeneProduct ncbigene:13619 full name: polyhomeotic-like 1 (Drosophila)
Zic2 GeneProduct ncbigene:22772 full name: zinc finger protein of the cerebellum 2
Etv5 GeneProduct ncbigene:104156 full name: ets variant gene 5
Tcfap2c GeneProduct ncbigene:21420 full name: transcription factor AP-2, gamma
Otx2 GeneProduct ncbigene:18424 full name: orthodenticle homolog 2 (Drosophila)
Zfp219 GeneProduct ncbigene:69890 full name: zinc finger protein 219
Rybp GeneProduct ncbigene:56353 full name: RING1 and YY1 binding protein
Tle4 GeneProduct ncbigene:21888 full name: Transducin-likeenhancerofsplit4
Rbpj GeneProduct ncbigene:19664 full name: recombination signal binding protein for immunoglobulin kappa J region
Sall1 GeneProduct ncbigene:58198 full name: sal-like 1 (Drosophila)
Fos GeneProduct ncbigene:14281 full name: FBJ osteosarcoma oncogene
Paf1 GeneProduct ncbigene:54624 full name: Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
Tcfe3 GeneProduct ncbigene:209446 full name: transcription factor E3
Kat5 GeneProduct ncbigene:81601 full name: K(lysine) acetyltransferase 5
Sos1 GeneProduct ncbigene:20662 full name: Son of sevenless homolog 1 (Drosophila)
Inhbb GeneProduct ncbigene:16324 full name: inhibin beta-B
Tgfb1 GeneProduct ncbigene:21803 full name: transforming growth factor, beta 1
Smad7 GeneProduct ncbigene:17131 full name: MADhomolog7
Ewsr1 GeneProduct ncbigene:14030 full name: Ewing sarcoma breakpoint region 1
Smarcc1 GeneProduct ncbigene:20588 full name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
Parp1 GeneProduct ncbigene:11545 full name: poly (ADP-ribose) polymerase family, member 1
Ctcf GeneProduct ncbigene:13018 full name: CCCTC-binding factor
Tsix GeneProduct ncbigene:22097 full name: X (inactive)-specific transcript, antisense
Mitf GeneProduct ncbigene:17342 full name: microphthalmia-associated transcription factor
Xite GeneProduct ncbigene:619209 full name: X-inactivation intergenic transcription element
Kdm4c GeneProduct ncbigene:76804 full name: lysine (K)-specific demethylase 4C
Kdm3a GeneProduct ncbigene:104263 full name: lysine (K)-specific demethylase 3A
Zfp57 GeneProduct ncbigene:22715 full name: zinc finger protein 57
Kpna2 GeneProduct ncbigene:16647 full name: karyopherin (importin) alpha 2
Casp3 GeneProduct ncbigene:12367 full name: caspase 3
Rtn4r GeneProduct ncbigene:65079 full name: reticulon 4 receptor
Cd44 GeneProduct ncbigene:12505 full name: CD44 antigen
Mapk1 GeneProduct ncbigene:26413 full name: mitogen-activated protein kinase 1
Nme2 GeneProduct ncbigene:18103 full name: non-metastatic cells 2, protein (NM23B) expressed in
Tcfeb GeneProduct ncbigene:21425 full name: transcription factor EB
Ehmt2 GeneProduct ncbigene:110147 full name: euchromatic histone lysine N-methyltransferase 2
Dnmt3l GeneProduct ncbigene:54427 full name: DNA (cytosine-5-)-methyltransferase 3-like
Irs1 GeneProduct ncbigene:16367 full name: insulin receptor substrate 1
Insr GeneProduct ncbigene:16337 full name: insulin receptor
Ins1 GeneProduct ncbigene:16333 full name: insulin I
Shh GeneProduct ncbigene:20423 full name: sonic hedgehog
Smo GeneProduct ncbigene:319757 full name: smoothened homolog (Drosophila)
Ehmt1 GeneProduct ncbigene:77683 full name: euchromatic histone methyltransferase 1
Gadd45gip1 GeneProduct ncbigene:102060 full name: growth arrest and DNA-damage-inducible, gamma interacting protein 1
Ncoa1 GeneProduct ncbigene:17977 full name: nuclear receptor coactivator 1
Ctbp2 GeneProduct ncbigene:13017 full name: C-terminal binding protein 2
Prkaca GeneProduct ncbigene:18747 full name: protein kinase, cAMP dependent, catalytic, alpha
Dnmt3a GeneProduct ncbigene:13435 full name: DNA methyltransferase 3A
Dnmt3b GeneProduct ncbigene:13436 full name: DNA methyltransferase 3B
Tcfap2a GeneProduct ncbigene:21418 full name: transcription factor AP-2, alpha
Satb1 GeneProduct ncbigene:20230 full name: special AT-rich sequence binding protein 1
Satb2 GeneProduct ncbigene:212712 full name: special AT-rich sequence binding protein 2
Pax6 GeneProduct ncbigene:77766 full name: paired box gene 6
Spp1 GeneProduct ncbigene:20750 full name: secreted phosphoprotein 1
Pias4 GeneProduct ncbigene:59004 full name: protein inhibitor of activated STAT 4; PIASy
Wwp2 GeneProduct ncbigene:66894 full name: WW domain containing E3 ubiquitin protein ligase 2
Creb1 GeneProduct ncbigene:12912 full name: cAMP responsive element binding protein 1
Uhrf1 GeneProduct ncbigene:18140 full name: ubiquitin-like, containing PHD and RING finger domains, 1
Rcn2 GeneProduct ncbigene:26611 full name: reticulocalbin 2
Stk40 GeneProduct ncbigene:74178 full name: serine/threonine kinase 40
Fgf5 GeneProduct ncbigene:14176 full name: fibroblast growth factor 5
Dazl GeneProduct ncbigene:13164 full name: deleted in azoospermia-like
Grsf1 GeneProduct ncbigene:231413 full name: G-rich RNA sequence binding factor 1
Aes GeneProduct ncbigene:14797 full name: amino-terminal enhancer of split
Pim1 GeneProduct ncbigene:18712 full name: proviral integration site 1
Pim3 GeneProduct ncbigene:223775 full name: proviral integration site 3
Ocln GeneProduct ncbigene:18260 full name: occludin
Atf2 GeneProduct ncbigene:11909 full name: activating transcription factor 2
Icam1 GeneProduct ncbigene:15894 full name: intercellular adhesion molecule 1
Brca1 GeneProduct ncbigene:12189 full name: breast cancer 1
Sumo1 GeneProduct ncbigene:22218 full name: SMT3 suppressor of mif two 3 homolog 1 (yeast)
Tet1 GeneProduct ncbigene:52463 full name: tet oncogene 1
T GeneProduct ncbigene:20997 full name: brachyury
Gbx2 GeneProduct ncbigene:14472 full name: gastrulation brain homeobox 2
Nr2f6 GeneProduct ncbigene:13864 full name: nuclear receptor subfamily 2, group F, member 6
Nr2c1 GeneProduct ncbigene:22025 full name: nuclear receptor subfamily 2, group C, member 1
Sf1 GeneProduct ncbigene:22668 full name: splicing factor 1
Usp7 GeneProduct ncbigene:252870 full name: ubiquitin specific peptidase 7
Cabin1 GeneProduct ncbigene:104248 full name: calcineurin binding protein 1
Pin1 GeneProduct ncbigene:23988 full name: protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1
Rock1 GeneProduct ncbigene:19877 full name: Rho-associated coiled-coil containing protein kinase 1
Rock2 GeneProduct ncbigene:19878 full name: Rho-associated coiled-coil containing protein kinase 2
Prkcc GeneProduct ncbigene:18752 full name: protein kinase C, gamma
E130012A19Rik GeneProduct ncbigene:103551 full name: RIKEN cDNA E130012A19 gene
Igfbp3 GeneProduct ncbigene:16009 full name: insulin-like growth factor binding protein 3
Bcam GeneProduct ncbigene:57278 full name: basal cell adhesion molecule
1600029D21Rik GeneProduct ncbigene:76509 full name: RIKEN cDNA 1600029D21 gene
Perp GeneProduct ncbigene:64058 full name: PERP, TP53 apoptosis effector
Dgka GeneProduct ncbigene:13139 full name: diacylglycerol kinase, alpha
Hira GeneProduct ncbigene:15260 full name: histone cell cycle regulation defective homolog A (S. cerevisiae)
Fam129a GeneProduct ncbigene:63913 full name: family with sequence similarity 129, member A
Hck GeneProduct ncbigene:15162 full name: hemopoietic cell kinase
Acvr1c GeneProduct ncbigene:269275 full name: activin A receptor, type IC / Alk7
Smarca5 GeneProduct ncbigene:93762 full name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
Ssrp1 GeneProduct ncbigene:20833 full name: structure specific recognition protein 1
Sall3 GeneProduct ncbigene:20689 full name: sal-like 3 (Drosophila)
Chd4 GeneProduct ncbigene:107932 full name: chromodomain helicase DNA binding protein 4
H3f3a GeneProduct ncbigene:15078 full name: H3 histone, family 3A
Atrx GeneProduct ncbigene:22589 full name: alpha thalassemia/mental retardation syndrome X-linked homolog (human)
Nkd1 GeneProduct ncbigene:93960 full name: naked cuticle 1 homolog (Drosophila)
Ppp2r1a GeneProduct ncbigene:51792 full name: protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform
Nobox GeneProduct ncbigene:18291 full name: NOBOX oogenesis homeobox
Gdf9 GeneProduct ncbigene:14566 full name: growth differentiation factor 9
Acvr1b GeneProduct ncbigene:11479 full name: activin A receptor, type 1B / Alk4
Mtf2 GeneProduct ncbigene:17765 full name: metal response element binding transcription factor 2 / PCL2
Rbbp4 GeneProduct ncbigene:19646 full name: retinoblastoma binding protein 4
Rbbp7 GeneProduct ncbigene:245688 full name: retinoblastoma binding protein 7
Suz12 GeneProduct ncbigene:52615 full name: suppressor of zeste 12 homolog (Drosophila)
Jarid2 GeneProduct ncbigene:16468 full name: jumonji, AT rich interactive domain 2
Nppb GeneProduct ncbigene:18158 full name: natriuretic peptide precursor type B
Npr1 GeneProduct ncbigene:18160 full name: natriuretic peptide receptor 1
Cad GeneProduct ncbigene:69719 full name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Dffa GeneProduct ncbigene:13347 full name: DNA fragmentation factor, alpha subunit
Ezh2 GeneProduct ncbigene:14056 full name: enhancer of zeste homolog 2 (Drosophila)
Smad3 GeneProduct ncbigene:17127 full name: MAD homolog 3 (Drosophila)
Ezh1 GeneProduct ncbigene:14055 full name: enhancer of zeste homolog 1 (Drosophila)
Eed GeneProduct ncbigene:13626 full name: embryonic ectoderm development
Ipo7 GeneProduct ncbigene:233726 full name: importin 7
Kpnb1 GeneProduct ncbigene:16211 full name: karyopherin (importin) beta 1
Xpo4 GeneProduct ncbigene:57258 full name: exportin 4
Ipo9 GeneProduct ncbigene:226432 full name: importin 9
Sp3 GeneProduct ncbigene:20687 full name: trans-acting transcription factor 3
Terf2 GeneProduct ncbigene:21750 full name: telomeric repeat binding factor 2
Hand2 GeneProduct ncbigene:15111 full name: heart and neural crest derivatives expressed transcript 2
Dpysl2 GeneProduct ncbigene:12934 full name: dihydropyrimidinase-like 2
Kdm5c GeneProduct ncbigene:20591 full name: lysine (K)-specific demethylase 5C
Kdm6b GeneProduct ncbigene:216850 full name: KDM1 lysine (K)-specific demethylase 6B
Mll2 GeneProduct ncbigene:381022 full name: myeloid/lymphoid or mixed-lineage leukemia 2, ALR
Kdm6a GeneProduct ncbigene:22289 full name: 4lysine (K)-specific demethylase 6A
Mef2c GeneProduct ncbigene:17260 full name: myocyte enhancer factor 2C
Mef2d GeneProduct ncbigene:17261 full name: myocyte enhancer factor 2D
Myod1 GeneProduct ncbigene:17927 full name: myogenic differentiation 1
Smurf1 GeneProduct ncbigene:75788 full name: SMAD specific E3 ubiquitin protein ligase 1
Sgk1 GeneProduct ncbigene:20393 full name: serum/glucocorticoid regulated kinase 1
Nedd4l GeneProduct ncbigene:83814 full name: neural precursor cell expressed, developmentally down-regulated gene 4-like
Hif1a GeneProduct ncbigene:15251 full name: hypoxia inducible factor 1, alpha subunit
Dppa4 GeneProduct ncbigene:73693 full name: developmental pluripotency associated 4
Klf2 GeneProduct ncbigene:16598 full name: Kruppel-like factor 2 (lung)
Hells GeneProduct ncbigene:15201 full name: helicase, lymphoid specific
Dnmt1 GeneProduct ncbigene:13433 full name: DNA methyltransferase (cytosine-5) 1
Ctr9 GeneProduct ncbigene:22083 full name: Ctr9 (Alco called 'SH2 domain-binding protein 1')
Leo1 GeneProduct ncbigene:235497 full name: Leo1
Cdc73 GeneProduct ncbigene:214498 full name: cell division cycle 73, Paf1/RNA polymerase II complex component, homolog
Wdr61 GeneProduct ncbigene:66317 full name: WD repeat domain 61
Carm1 GeneProduct ncbigene:74766 full name: coactivator-associated arginine methyltransferase 1
Rbl2 GeneProduct ncbigene:19651 full name: retinoblastoma-like 2
Cdk2 GeneProduct ncbigene:12566 full name: cyclin-dependent kinase 2
Relb GeneProduct ncbigene:19698 full name: avian reticuloendotheliosis viral (v-rel) oncogene related B
Setdb1 GeneProduct ncbigene:76893 full name: SET domain, bifurcated 1
Ncl GeneProduct ncbigene:17975 full name: nucleolin
Lyar GeneProduct ncbigene:17089 full name: Ly1 antibody reactive clone
Trim24 GeneProduct ncbigene:21848 full name: tripartite motif-containing 24
Twist1 GeneProduct ncbigene:22160 full name: twist gene homolog 1 (Drosophila)
Zscan10 GeneProduct ncbigene:332221 full name: zinc finger and SCAN domain containing 10
Smarca2 GeneProduct ncbigene:67155 full name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Pml GeneProduct ncbigene:18854 full name: promyelocytic leukemia
Kdm1a GeneProduct ncbigene:99982 full name: lysine (K)-specific demethylase 1A
Gatad2a GeneProduct ncbigene:234366 full name: GATA zinc finger domain containing 2A
Rela GeneProduct ncbigene:19697 full name: v-rel reticuloendotheliosis viral oncogene homolog A (avian)
Smarca4 GeneProduct ncbigene:20586 full name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Gatad2b GeneProduct ncbigene:229542 full name: GATA zinc finger domain containing 2B
Pbrm1 GeneProduct ncbigene:66923 full name: polybromo 1 / BAF180
Hdac1 GeneProduct ncbigene:433759 full name: histone deacetylase 1
Mta1 GeneProduct ncbigene:116870 full name: metastasis associated 1
Sin3a GeneProduct ncbigene:20466 full name: transcriptional regulator, SIN3A (yeast)
Klf5 GeneProduct ncbigene:12224 full name: Kruppel-like factor 5
Mta2 GeneProduct ncbigene:23942 full name: metastasis-associated gene family, member 2
Zmym2 GeneProduct ncbigene:76007 full name: zinc finger, MYM-type 2
Tle2 GeneProduct ncbigene:21886 full name: transducin-like enhancer of split 2, homolog of Drosophila E(spl)

References

  1. Octamer-dependent regulation of the kFGF gene in embryonal carcinoma and embryonic stem cells. Schoorlemmer J, Kruijer W. Mech Dev. 1991 Dec;36(1–2):75–86. PubMed Europe PMC Scholia
  2. Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3. Yuan H, Corbi N, Basilico C, Dailey L. Genes Dev. 1995 Nov 1;9(21):2635–45. PubMed Europe PMC Scholia
  3. Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, et al. Science. 1994 Nov 25;266(5189):1376–80. PubMed Europe PMC Scholia
  4. Characterization of a negative retinoic acid response element in the murine Oct4 promoter. Schoorlemmer J, van Puijenbroek A, van Den Eijnden M, Jonk L, Pals C, Kruijer W. Mol Cell Biol. 1994 Feb;14(2):1122–36. PubMed Europe PMC Scholia
  5. Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes. van Lohuizen M, Tijms M, Voncken JW, Schumacher A, Magnuson T, Wientjens E. Mol Cell Biol. 1998 Jun;18(6):3572–9. PubMed Europe PMC Scholia
  6. Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3. Niwa H, Burdon T, Chambers I, Smith A. Genes Dev. 1998 Jul 1;12(13):2048–60. PubMed Europe PMC Scholia
  7. New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2. Botquin V, Hess H, Fuhrmann G, Anastassiadis C, Gross MK, Vriend G, et al. Genes Dev. 1998 Jul 1;12(13):2073–90. PubMed Europe PMC Scholia
  8. Activation of mitochondrial Raf-1 is involved in the antiapoptotic effects of Akt. Majewski M, Nieborowska-Skorska M, Salomoni P, Slupianek A, Reiss K, Trotta R, et al. Cancer Res. 1999 Jun 15;59(12):2815–9. PubMed Europe PMC Scholia
  9. Synergy of SF1 and RAR in activation of Oct-3/4 promoter. Barnea E, Bergman Y. J Biol Chem. 2000 Mar 3;275(9):6608–19. PubMed Europe PMC Scholia
  10. Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5. Kurooka H, Honjo T. J Biol Chem. 2000 Jun 2;275(22):17211–20. PubMed Europe PMC Scholia
  11. The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter. Zhang W, Geiman DE, Shields JM, Dang DT, Mahatan CS, Kaestner KH, et al. J Biol Chem. 2000 Jun 16;275(24):18391–8. PubMed Europe PMC Scholia
  12. A novel transrepression pathway of c-Myc. Recruitment of a transcriptional corepressor complex to c-Myc by MM-1, a c-Myc-binding protein. Satou A, Taira T, Iguchi-Ariga SM, Ariga H. J Biol Chem. 2001 Dec 7;276(49):46562–7. PubMed Europe PMC Scholia
  13. Mouse germline restriction of Oct4 expression by germ cell nuclear factor. Fuhrmann G, Chung AC, Jackson KJ, Hummelke G, Baniahmad A, Sutter J, et al. Dev Cell. 2001 Sep;1(3):377–87. PubMed Europe PMC Scholia
  14. Insulin signalling and the regulation of glucose and lipid metabolism. Saltiel AR, Kahn CR. Nature. 2001 Dec 13;414(6865):799–806. PubMed Europe PMC Scholia
  15. Thrombopoietin acts synergistically with LIF to maintain an undifferentiated state of embryonic stem cells homozygous for a Shp-2 deletion mutation. Xie X, Chan RJ, Yoder MC. FEBS Lett. 2002 Oct 9;529(2–3):361–4. PubMed Europe PMC Scholia
  16. Degradation of chromosomal DNA during apoptosis. Nagata S, Nagase H, Kawane K, Mukae N, Fukuyama H. Cell Death Differ. 2003 Jan;10(1):108–16. PubMed Europe PMC Scholia
  17. Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. Tokuzawa Y, Kaiho E, Maruyama M, Takahashi K, Mitsui K, Maeda M, et al. Mol Cell Biol. 2003 Apr;23(8):2699–708. PubMed Europe PMC Scholia
  18. Role of ERas in promoting tumour-like properties in mouse embryonic stem cells. Takahashi K, Mitsui K, Yamanaka S. Nature. 2003 May 29;423(6939):541–5. PubMed Europe PMC Scholia
  19. Identification and characterisation of mRif1: a mouse telomere-associated protein highly expressed in germ cells and embryo-derived pluripotent stem cells. Adams IR, McLaren A. Dev Dyn. 2004 Apr;229(4):733–44. PubMed Europe PMC Scholia
  20. Wwp2, an E3 ubiquitin ligase that targets transcription factor Oct-4 for ubiquitination. Xu HM, Liao B, Zhang QJ, Wang BB, Li H, Zhong XM, et al. J Biol Chem. 2004 May 28;279(22):23495–503. PubMed Europe PMC Scholia
  21. BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways. Qi X, Li TG, Hao J, Hu J, Wang J, Simmons H, et al. Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6027–32. PubMed Europe PMC Scholia
  22. Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. Paling NRD, Wheadon H, Bone HK, Welham MJ. J Biol Chem. 2004 Nov 12;279(46):48063–70. PubMed Europe PMC Scholia
  23. Conserved and divergent paths that regulate self-renewal in mouse and human embryonic stem cells. Rao M. Dev Biol. 2004 Nov 15;275(2):269–86. PubMed Europe PMC Scholia
  24. Oct-3/4 and Sox2 regulate Oct-3/4 gene in embryonic stem cells. Okumura-Nakanishi S, Saito M, Niwa H, Ishikawa F. J Biol Chem. 2005 Feb 18;280(7):5307–17. PubMed Europe PMC Scholia
  25. p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression. Lin T, Chao C, Saito S, Mazur SJ, Murphy ME, Appella E, et al. Nat Cell Biol. 2005 Feb;7(2):165–71. PubMed Europe PMC Scholia
  26. LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism. Cartwright P, McLean C, Sheppard A, Rivett D, Jones K, Dalton S. Development. 2005 Mar;132(5):885–96. PubMed Europe PMC Scholia
  27. The C terminus of p53 family proteins is a cell fate determinant. Harms KL, Chen X. Mol Cell Biol. 2005 Mar;25(5):2014–30. PubMed Europe PMC Scholia
  28. Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression. Kuroda T, Tada M, Kubota H, Kimura H, Hatano S ya, Suemori H, et al. Mol Cell Biol. 2005 Mar;25(6):2475–85. PubMed Europe PMC Scholia
  29. Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development. Gu P, Goodwin B, Chung ACK, Xu X, Wheeler DA, Price RR, et al. Mol Cell Biol. 2005 May;25(9):3492–505. PubMed Europe PMC Scholia
  30. Transcriptional regulation of nanog by OCT4 and SOX2. Rodda DJ, Chew JL, Lim LH, Loh YH, Wang B, Ng HH, et al. J Biol Chem. 2005 Jul 1;280(26):24731–7. PubMed Europe PMC Scholia
  31. Stimulation of Oct-4 activity by Ewing’s sarcoma protein. Lee J, Rhee BK, Bae GY, Han YM, Kim J. Stem Cells. 2005;23(6):738–51. PubMed Europe PMC Scholia
  32. The circuitry of a master switch: Myod and the regulation of skeletal muscle gene transcription. Tapscott SJ. Development. 2005 Jun;132(12):2685–95. PubMed Europe PMC Scholia
  33. Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Chew JL, Loh YH, Zhang W, Chen X, Tam WL, Yeap LS, et al. Mol Cell Biol. 2005 Jul;25(14):6031–46. PubMed Europe PMC Scholia
  34. Microarray analysis of LIF/Stat3 transcriptional targets in embryonic stem cells. Sekkaï D, Gruel G, Herry M, Moucadel V, Constantinescu SN, Albagli O, et al. Stem Cells. 2005;23(10):1634–42. PubMed Europe PMC Scholia
  35. Core transcriptional regulatory circuitry in human embryonic stem cells. Boyer LA, Lee TI, Cole MF, Johnstone SE, Levine SS, Zucker JP, et al. Cell. 2005 Sep 23;122(6):947–56. PubMed Europe PMC Scholia
  36. Regulatory networks in embryo-derived pluripotent stem cells. Boiani M, Schöler HR. Nat Rev Mol Cell Biol. 2005 Nov;6(11):872–84. PubMed Europe PMC Scholia
  37. The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene. Rowland BD, Bernards R, Peeper DS. Nat Cell Biol. 2005 Nov;7(11):1074–82. PubMed Europe PMC Scholia
  38. Role of the phosphoinositide 3-kinase pathway in mouse embryonic stem (ES) cells. Takahashi K, Murakami M, Yamanaka S. Biochem Soc Trans. 2005 Dec;33(Pt 6):1522–5. PubMed Europe PMC Scholia
  39. Dual regulation of c-Myc by p300 via acetylation-dependent control of Myc protein turnover and coactivation of Myc-induced transcription. Faiola F, Liu X, Lo S, Pan S, Zhang K, Lymar E, et al. Mol Cell Biol. 2005 Dec;25(23):10220–34. PubMed Europe PMC Scholia
  40. The Wnt-inducible transcription factor Twist1 inhibits chondrogenesis. Reinhold MI, Kapadia RM, Liao Z, Naski MC. J Biol Chem. 2006 Jan 20;281(3):1381–8. PubMed Europe PMC Scholia
  41. Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. Niwa H, Toyooka Y, Shimosato D, Strumpf D, Takahashi K, Yagi R, et al. Cell. 2005 Dec 2;123(5):917–29. PubMed Europe PMC Scholia
  42. WNT/beta-catenin pathway up-regulates Stat3 and converges on LIF to prevent differentiation of mouse embryonic stem cells. Hao J, Li TG, Qi X, Zhao DF, Zhao GQ. Dev Biol. 2006 Feb 1;290(1):81–91. PubMed Europe PMC Scholia
  43. G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis. Feldman N, Gerson A, Fang J, Li E, Zhang Y, Shinkai Y, et al. Nat Cell Biol. 2006 Feb;8(2):188–94. PubMed Europe PMC Scholia
  44. The NuRD component Mbd3 is required for pluripotency of embryonic stem cells. Kaji K, Caballero IM, MacLeod R, Nichols J, Wilson VA, Hendrich B. Nat Cell Biol. 2006 Mar;8(3):285–92. PubMed Europe PMC Scholia
  45. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Loh YH, Wu Q, Chew JL, Vega VB, Zhang W, Chen X, et al. Nat Genet. 2006 Apr;38(4):431–40. PubMed Europe PMC Scholia
  46. Functional analysis of two Sp1/Sp3 binding sites in murine Nanog gene promoter. Wu DY, Yao Z. Cell Res. 2006 Mar;16(3):319–22. PubMed Europe PMC Scholia
  47. Molecular enzymology of mammalian DNA methyltransferases. Jeltsch A. Curr Top Microbiol Immunol. 2006;301:203–25. PubMed Europe PMC Scholia
  48. The orphan nuclear receptor GCNF recruits DNA methyltransferase for Oct-3/4 silencing. Sato N, Kondo M, Arai K ichi. Biochem Biophys Res Commun. 2006 Jun 9;344(3):845–51. PubMed Europe PMC Scholia
  49. Regulation of the pluripotency marker Rex-1 by Nanog and Sox2. Shi W, Wang H, Pan G, Geng Y, Guo Y, Pei D. J Biol Chem. 2006 Aug 18;281(33):23319–25. PubMed Europe PMC Scholia
  50. The murine homolog of SALL4, a causative gene in Okihiro syndrome, is essential for embryonic stem cell proliferation, and cooperates with Sall1 in anorectal, heart, brain and kidney development. Sakaki-Yumoto M, Kobayashi C, Sato A, Fujimura S, Matsumoto Y, Takasato M, et al. Development. 2006 Aug;133(15):3005–13. PubMed Europe PMC Scholia
  51. A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal. Pan G, Li J, Zhou Y, Zheng H, Pei D. FASEB J. 2006 Aug;20(10):1730–2. PubMed Europe PMC Scholia
  52. Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells. Suzuki A, Raya Á, Kawakami Y, Morita M, Matsui T, Nakashima K, et al. Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10294–9. PubMed Europe PMC Scholia
  53. Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells. Wu Q, Chen X, Zhang J, Loh YH, Low TY, Zhang W, et al. J Biol Chem. 2006 Aug 25;281(34):24090–4. PubMed Europe PMC Scholia
  54. Repression of Nanog gene transcription by Tcf3 limits embryonic stem cell self-renewal. Pereira L, Yi F, Merrill BJ. Mol Cell Biol. 2006 Oct;26(20):7479–91. PubMed Europe PMC Scholia
  55. The Grb2/Mek pathway represses Nanog in murine embryonic stem cells. Hamazaki T, Kehoe SM, Nakano T, Terada N. Mol Cell Biol. 2006 Oct;26(20):7539–49. PubMed Europe PMC Scholia
  56. Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells. Nakatake Y, Fukui N, Iwamatsu Y, Masui S, Takahashi K, Yagi R, et al. Mol Cell Biol. 2006 Oct;26(20):7772–82. PubMed Europe PMC Scholia
  57. Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1. Zhang J, Tam WL, Tong GQ, Wu Q, Chan HY, Soh BS, et al. Nat Cell Biol. 2006 Oct;8(10):1114–23. PubMed Europe PMC Scholia
  58. Identification of Jmjd1a as a STAT3 downstream gene in mES cells. Ko SY, Kang HY, Lee HS, Han SY, Hong SH. Cell Struct Funct. 2006;31(2):53–62. PubMed Europe PMC Scholia
  59. Characterization of NOBOX DNA binding specificity and its regulation of Gdf9 and Pou5f1 promoters. Choi Y, Rajkovic A. J Biol Chem. 2006 Nov 24;281(47):35747–56. PubMed Europe PMC Scholia
  60. Mechanisms controlling embryonic stem cell self-renewal and differentiation. Sun Y, Li H, Yang H, Rao MS, Zhan M. Crit Rev Eukaryot Gene Expr. 2006;16(3):211–31. PubMed Europe PMC Scholia
  61. A protein interaction network for pluripotency of embryonic stem cells. Wang J, Rao S, Chu J, Shen X, Levasseur DN, Theunissen TW, et al. Nature. 2006 Nov 16;444(7117):364–8. PubMed Europe PMC Scholia
  62. Activin-Nodal signaling is involved in propagation of mouse embryonic stem cells. Ogawa K, Saito A, Matsui H, Suzuki H, Ohtsuka S, Shimosato D, et al. J Cell Sci. 2007 Jan 1;120(Pt 1):55–65. PubMed Europe PMC Scholia
  63. Dissecting Oct3/4-regulated gene networks in embryonic stem cells by expression profiling. Matoba R, Niwa H, Masui S, Ohtsuka S, Carter MG, Sharov AA, et al. PLoS One. 2006 Dec 20;1(1):e26. PubMed Europe PMC Scholia
  64. SUMOylation of Tr2 orphan receptor involves Pml and fine-tunes Oct4 expression in stem cells. Park SW, Hu X, Gupta P, Lin YP, Ha SG, Wei LN. Nat Struct Mol Biol. 2007 Jan;14(1):68–75. PubMed Europe PMC Scholia
  65. Beta-catenin up-regulates Nanog expression through interaction with Oct-3/4 in embryonic stem cells. Takao Y, Yokota T, Koide H. Biochem Biophys Res Commun. 2007 Feb 16;353(3):699–705. PubMed Europe PMC Scholia
  66. Nanog and transcriptional networks in embryonic stem cell pluripotency. Pan G, Thomson JA. Cell Res. 2007 Jan;17(1):42–9. PubMed Europe PMC Scholia
  67. How is pluripotency determined and maintained? Niwa H. Development. 2007 Feb;134(4):635–46. PubMed Europe PMC Scholia
  68. Identification of a Ctcf cofactor, Yy1, for the X chromosome binary switch. Donohoe ME, Zhang LF, Xu N, Shi Y, Lee JT. Mol Cell. 2007 Jan 12;25(1):43–56. PubMed Europe PMC Scholia
  69. Zic3 is required for maintenance of pluripotency in embryonic stem cells. Lim LS, Loh YH, Zhang W, Li Y, Chen X, Wang Y, et al. Mol Biol Cell. 2007 Apr;18(4):1348–58. PubMed Europe PMC Scholia
  70. Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. Barreto G, Schäfer A, Marhold J, Stach D, Swaminathan SK, Handa V, et al. Nature. 2007 Feb 8;445(7128):671–5. PubMed Europe PMC Scholia
  71. Balancing BMP signaling through integrated inputs into the Smad1 linker. Sapkota G, Alarcón C, Spagnoli FM, Brivanlou AH, Massagué J. Mol Cell. 2007 Feb 9;25(3):441–54. PubMed Europe PMC Scholia
  72. Oct4 and Sox2 directly regulate expression of another pluripotency transcription factor, Zfp206, in embryonic stem cells. Wang ZX, Teh CHL, Kueh JLL, Lufkin T, Robson P, Stanton LW. J Biol Chem. 2007 Apr 27;282(17):12822–30. PubMed Europe PMC Scholia
  73. Hypoxia-inducible factor-1 alpha inhibits self-renewal of mouse embryonic stem cells in Vitro via negative regulation of the leukemia inhibitory factor-STAT3 pathway. Jeong CH, Lee HJ, Cha JH, Kim JH, Kim KR, Kim JH, et al. J Biol Chem. 2007 May 4;282(18):13672–9. PubMed Europe PMC Scholia
  74. Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Miyabayashi T, Teo JL, Yamamoto M, McMillan M, Nguyen C, Kahn M. Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5668–73. PubMed Europe PMC Scholia
  75. Zfx controls the self-renewal of embryonic and hematopoietic stem cells. Galan-Caridad JM, Harel S, Arenzana TL, Hou ZE, Doetsch FK, Mirny LA, et al. Cell. 2007 Apr 20;129(2):345–57. PubMed Europe PMC Scholia
  76. Post-translational modification of POU domain transcription factor Oct-4 by SUMO-1. Zhang Z, Liao B, Xu M, Jin Y. FASEB J. 2007 Oct;21(12):3042–51. PubMed Europe PMC Scholia
  77. Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells. Masui S, Nakatake Y, Toyooka Y, Shimosato D, Yagi R, Takahashi K, et al. Nat Cell Biol. 2007 Jun;9(6):625–35. PubMed Europe PMC Scholia
  78. Oct4 targets regulatory nodes to modulate stem cell function. Campbell PA, Perez-Iratxeta C, Andrade-Navarro MA, Rudnicki MA. PLoS One. 2007 Jun 20;2(6):e553. PubMed Europe PMC Scholia
  79. Pluripotent stem cells and their niches. Lensch MW, Daheron L, Schlaeger TM. Stem Cell Rev. 2006;2(3):185–201. PubMed Europe PMC Scholia
  80. Zfp206 is a transcription factor that controls pluripotency of embryonic stem cells. Wang ZX, Kueh JLL, Teh CHL, Rossbach M, Lim L, Li P, et al. Stem Cells. 2007 Sep;25(9):2173–82. PubMed Europe PMC Scholia
  81. WNT signaling pathway and stem cell signaling network. Katoh M, Katoh M. Clin Cancer Res. 2007 Jul 15;13(14):4042–5. PubMed Europe PMC Scholia
  82. UHRF1 plays a role in maintaining DNA methylation in mammalian cells. Bostick M, Kim JK, Estève PO, Clark A, Pradhan S, Jacobsen SE. Science. 2007 Sep 21;317(5845):1760–4. PubMed Europe PMC Scholia
  83. UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Agger K, Cloos PAC, Christensen J, Pasini D, Rose S, Rappsilber J, et al. Nature. 2007 Oct 11;449(7163):731–4. PubMed Europe PMC Scholia
  84. The molecular mechanism of embryonic stem cell pluripotency and self-renewal. Liu Y, Ji L, Ten Y, Wang Y, Pei X. Sci China C Life Sci. 2007 Oct;50(5):619–23. PubMed Europe PMC Scholia
  85. Kruppel-like factor 4 is acetylated by p300 and regulates gene transcription via modulation of histone acetylation. Evans PM, Zhang W, Chen X, Yang J, Bhakat KK, Liu C. J Biol Chem. 2007 Nov 23;282(47):33994–4002. PubMed Europe PMC Scholia
  86. Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog. Li JY, Pu MT, Hirasawa R, Li BZ, Huang YN, Zeng R, et al. Mol Cell Biol. 2007 Dec;27(24):8748–59. PubMed Europe PMC Scholia
  87. Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells. Loh YH, Zhang W, Chen X, George J, Ng HH. Genes Dev. 2007 Oct 15;21(20):2545–57. PubMed Europe PMC Scholia
  88. A gene regulatory network in mouse embryonic stem cells. Zhou Q, Chipperfield H, Melton DA, Wong WH. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16438–43. PubMed Europe PMC Scholia
  89. Small molecules in stem cell self-renewal and differentiation. Schugar RC, Robbins PD, Deasy BM. Gene Ther. 2008 Jan;15(2):126–35. PubMed Europe PMC Scholia
  90. PIAS proteins as repressors of Oct4 function. Tolkunova E, Malashicheva A, Parfenov VN, Sustmann C, Grosschedl R, Tomilin A. J Mol Biol. 2007 Dec 14;374(5):1200–12. PubMed Europe PMC Scholia
  91. STAT3 and Oct-3/4 control histone modification through induction of Eed in embryonic stem cells. Ura H, Usuda M, Kinoshita K, Sun C, Mori K, Akagi T, et al. J Biol Chem. 2008 Apr 11;283(15):9713–23. PubMed Europe PMC Scholia
  92. Intracellular signaling pathways regulating pluripotency of embryonic stem cells. Okita K, Yamanaka S. Curr Stem Cell Res Ther. 2006 Jan;1(1):103–11. PubMed Europe PMC Scholia
  93. Nanog maintains pluripotency of mouse embryonic stem cells by inhibiting NFkappaB and cooperating with Stat3. Torres J, Watt FM. Nat Cell Biol. 2008 Feb;10(2):194–201. PubMed Europe PMC Scholia
  94. A core Klf circuitry regulates self-renewal of embryonic stem cells. Jiang J, Chan YS, Loh YH, Cai J, Tong GQ, Lim CA, et al. Nat Cell Biol. 2008 Mar;10(3):353–60. PubMed Europe PMC Scholia
  95. Nuclear Receptors in Regulation of Mouse ES Cell Pluripotency and Differentiation. Mullen EM, Gu P, Cooney AJ. PPAR Res. 2007;2007:61563. PubMed Europe PMC Scholia
  96. Capturing pluripotency. Silva J, Smith A. Cell. 2008 Feb 22;132(4):532–6. PubMed Europe PMC Scholia
  97. Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Jaenisch R, Young R. Cell. 2008 Feb 22;132(4):567–82. PubMed Europe PMC Scholia
  98. A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Benetti R, Gonzalo S, Jaco I, Muñoz P, Gonzalez S, Schoeftner S, et al. Nat Struct Mol Biol. 2008 Mar;15(3):268–79. PubMed Europe PMC Scholia
  99. Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity. Endoh M, Endo TA, Endoh T, Fujimura Y ichi, Ohara O, Toyoda T, et al. Development. 2008 Apr;135(8):1513–24. PubMed Europe PMC Scholia
  100. Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells. Cole MF, Johnstone SE, Newman JJ, Kagey MH, Young RA. Genes Dev. 2008 Mar 15;22(6):746–55. PubMed Europe PMC Scholia
  101. Identification of DPPA4 and other genes as putative Sox2:Oct-3/4 target genes using a combination of in silico analysis and transcription-based assays. Chakravarthy H, Boer B, Desler M, Mallanna SK, McKeithan TW, Rizzino A. J Cell Physiol. 2008 Sep;216(3):651–62. PubMed Europe PMC Scholia
  102. Requirement of Nanog dimerization for stem cell self-renewal and pluripotency. Wang J, Levasseur DN, Orkin SH. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6326–31. PubMed Europe PMC Scholia
  103. Regulation of Sox2 by STAT3 initiates commitment to the neural precursor cell fate. Foshay KM, Gallicano GI. Stem Cells Dev. 2008 Apr;17(2):269–78. PubMed Europe PMC Scholia
  104. Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells. Liang J, Wan M, Zhang Y, Gu P, Xin H, Jung SY, et al. Nat Cell Biol. 2008 Jun;10(6):731–9. PubMed Europe PMC Scholia
  105. A hierarchical network controls protein translation during murine embryonic stem cell self-renewal and differentiation. Sampath P, Pritchard DK, Pabon L, Reinecke H, Schwartz SM, Morris DR, et al. Cell Stem Cell. 2008 May 8;2(5):448–60. PubMed Europe PMC Scholia
  106. T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways. Tam WL, Lim CY, Han J, Zhang J, Ang YS, Ng HH, et al. Stem Cells. 2008 Aug;26(8):2019–31. PubMed Europe PMC Scholia
  107. Caspase activity mediates the differentiation of embryonic stem cells. Fujita J, Crane AM, Souza MK, Dejosez M, Kyba M, Flavell RA, et al. Cell Stem Cell. 2008 Jun 5;2(6):595–601. PubMed Europe PMC Scholia
  108. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Chen X, Xu H, Yuan P, Fang F, Huss M, Vega VB, et al. Cell. 2008 Jun 13;133(6):1106–17. PubMed Europe PMC Scholia
  109. The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells. Ramos JW. Int J Biochem Cell Biol. 2008;40(12):2707–19. PubMed Europe PMC Scholia
  110. B-MYB is essential for normal cell cycle progression and chromosomal stability of embryonic stem cells. Tarasov KV, Tarasova YS, Tam WL, Riordon DR, Elliott ST, Kania G, et al. PLoS One. 2008 Jun 25;3(6):e2478. PubMed Europe PMC Scholia
  111. Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cells. Dejosez M, Krumenacker JS, Zitur LJ, Passeri M, Chu LF, Songyang Z, et al. Cell. 2008 Jun 27;133(7):1162–74. PubMed Europe PMC Scholia
  112. An RNAi screen of chromatin proteins identifies Tip60-p400 as a regulator of embryonic stem cell identity. Fazzio TG, Huff JT, Panning B. Cell. 2008 Jul 11;134(1):162–74. PubMed Europe PMC Scholia
  113. Prospective of Ras signaling in stem cells. Chakrabarty K, Heumann R. Biol Chem. 2008 Jul;389(7):791–8. PubMed Europe PMC Scholia
  114. Klf5 is involved in self-renewal of mouse embryonic stem cells. Parisi S, Passaro F, Aloia L, Manabe I, Nagai R, Pastore L, et al. J Cell Sci. 2008 Aug 15;121(Pt 16):2629–34. PubMed Europe PMC Scholia
  115. Estrogen-related receptor beta interacts with Oct4 to positively regulate Nanog gene expression. van den Berg DLC, Zhang W, Yates A, Engelen E, Takacs K, Bezstarosti K, et al. Mol Cell Biol. 2008 Oct;28(19):5986–95. PubMed Europe PMC Scholia
  116. Zfp143 regulates Nanog through modulation of Oct4 binding. Chen X, Fang F, Liou YC, Ng HH. Stem Cells. 2008 Nov;26(11):2759–67. PubMed Europe PMC Scholia
  117. The transcription factor Zfp281 controls embryonic stem cell pluripotency by direct activation and repression of target genes. Wang ZX, Teh CHL, Chan CMY, Chu C, Rossbach M, Kunarso G, et al. Stem Cells. 2008 Nov;26(11):2791–9. PubMed Europe PMC Scholia
  118. Pleiotropic function of FGF-4: its role in development and stem cells. Kosaka N, Sakamoto H, Terada M, Ochiya T. Dev Dyn. 2009 Feb;238(2):265–76. PubMed Europe PMC Scholia
  119. Molecular coupling of Xist regulation and pluripotency. Navarro P, Chambers I, Karwacki-Neisius V, Chureau C, Morey C, Rougeulle C, et al. Science. 2008 Sep 19;321(5896):1693–5. PubMed Europe PMC Scholia
  120. Evolutionarily conserved transcriptional co-expression guiding embryonic stem cell differentiation. Sun Y, Li H, Liu Y, Mattson MP, Rao MS, Zhan M. PLoS One. 2008;3(10):e3406. PubMed Europe PMC Scholia
  121. De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes. Epsztejn-Litman S, Feldman N, Abu-Remaileh M, Shufaro Y, Gerson A, Ueda J, et al. Nat Struct Mol Biol. 2008 Nov;15(11):1176–83. PubMed Europe PMC Scholia
  122. Esrrb activates Oct4 transcription and sustains self-renewal and pluripotency in embryonic stem cells. Zhang X, Zhang J, Wang T, Esteban MA, Pei D. J Biol Chem. 2008 Dec 19;283(51):35825–33. PubMed Europe PMC Scholia
  123. Krüppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs. Ema M, Mori D, Niwa H, Hasegawa Y, Yamanaka Y, Hitoshi S, et al. Cell Stem Cell. 2008 Nov 6;3(5):555–67. PubMed Europe PMC Scholia
  124. Yamanaka factors critically regulate the developmental signaling network in mouse embryonic stem cells. Liu X, Huang J, Chen T, Wang Y, Xin S, Li J, et al. Cell Res. 2008 Dec;18(12):1177–89. PubMed Europe PMC Scholia
  125. Role for Med12 in regulation of Nanog and Nanog target genes. Tutter AV, Kowalski MP, Baltus GA, Iourgenko V, Labow M, Li E, et al. J Biol Chem. 2009 Feb 6;284(6):3709–18. PubMed Europe PMC Scholia
  126. Genome-wide analysis reveals Sall4 to be a major regulator of pluripotency in murine-embryonic stem cells. Yang J, Chai L, Fowles TC, Alipio Z, Xu D, Fink LM, et al. Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19756–61. PubMed Europe PMC Scholia
  127. Stat3 and c-Myc genome-wide promoter occupancy in embryonic stem cells. Kidder BL, Yang J, Palmer S. PLoS One. 2008;3(12):e3932. PubMed Europe PMC Scholia
  128. Cdk2ap1 is required for epigenetic silencing of Oct4 during murine embryonic stem cell differentiation. Deshpande AM, Dai YS, Kim Y, Kim J, Kimlin L, Gao K, et al. J Biol Chem. 2009 Mar 6;284(10):6043–7. PubMed Europe PMC Scholia
  129. Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb. Feng B, Jiang J, Kraus P, Ng JH, Heng JCD, Chan YS, et al. Nat Cell Biol. 2009 Feb;11(2):197–203. PubMed Europe PMC Scholia
  130. Critical roles of coactivator p300 in mouse embryonic stem cell differentiation and Nanog expression. Zhong X, Jin Y. J Biol Chem. 2009 Apr 3;284(14):9168–75. PubMed Europe PMC Scholia
  131. Signal transducer and activator of transcription 3 is a transcriptional factor regulating the gene expression of SALL4. Bard JD, Gelebart P, Amin HM, Young LC, Ma Y, Lai R. FASEB J. 2009 May;23(5):1405–14. PubMed Europe PMC Scholia
  132. Post-translational regulation of Oct4 transcriptional activity. Saxe JP, Tomilin A, Schöler HR, Plath K, Huang J. PLoS One. 2009;4(2):e4467. PubMed Europe PMC Scholia
  133. Genome-wide discovery of functional transcription factor binding sites by comparative genomics: the case of Stat3. Vallania F, Schiavone D, Dewilde S, Pupo E, Garbay S, Calogero R, et al. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5117–22. PubMed Europe PMC Scholia
  134. Mouse cofactor of BRCA1 (Cobra1) is required for early embryogenesis. Amleh A, Nair SJ, Sun J, Sutherland A, Hasty P, Li R. PLoS One. 2009;4(4):e5034. PubMed Europe PMC Scholia
  135. A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity. Ding L, Paszkowski-Rogacz M, Nitzsche A, Slabicki MM, Heninger AK, de Vries I, et al. Cell Stem Cell. 2009 May 8;4(5):403–15. PubMed Europe PMC Scholia
  136. Exportin 4 mediates a novel nuclear import pathway for Sox family transcription factors. Gontan C, Güttler T, Engelen E, Demmers J, Fornerod M, Grosveld FG, et al. J Cell Biol. 2009 Apr 6;185(1):27–34. PubMed Europe PMC Scholia
  137. BNP signaling is crucial for embryonic stem cell proliferation. Abdelalim EM, Tooyama I. PLoS One. 2009;4(4):e5341. PubMed Europe PMC Scholia
  138. Nogo-66 regulates nanog expression through stat3 pathway in murine embryonic stem cells. Gao Y, Wang B, Xiao Z, Chen B, Han J, Wang X, et al. Stem Cells Dev. 2010 Jan;19(1):53–60. PubMed Europe PMC Scholia
  139. Regulatory circuits underlying pluripotency and reprogramming. Do JT, Schöler HR. Trends Pharmacol Sci. 2009 Jun;30(6):296–302. PubMed Europe PMC Scholia
  140. A small molecule primes embryonic stem cells for differentiation. Zhu S, Wurdak H, Wang J, Lyssiotis CA, Peters EC, Cho CY, et al. Cell Stem Cell. 2009 May 8;4(5):416–26. PubMed Europe PMC Scholia
  141. Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex. Lu J, Jeong HW, Kong N, Yang Y, Carroll J, Luo HR, et al. PLoS One. 2009;4(5):e5577. PubMed Europe PMC Scholia
  142. Ly-1 antibody reactive clone is an important nucleolar protein for control of self-renewal and differentiation in embryonic stem cells. Li H, Wang B, Yang A, Lu R, Wang W, Zhou Y, et al. Stem Cells. 2009 Jun;27(6):1244–54. PubMed Europe PMC Scholia
  143. Acetylation and activation of STAT3 mediated by nuclear translocation of CD44. Lee JL, Wang MJ, Chen JY. J Cell Biol. 2009 Jun 15;185(6):949–57. PubMed Europe PMC Scholia
  144. Dax1 binds to Oct3/4 and inhibits its transcriptional activity in embryonic stem cells. Sun C, Nakatake Y, Akagi T, Ura H, Matsuda T, Nishiyama A, et al. Mol Cell Biol. 2009 Aug;29(16):4574–83. PubMed Europe PMC Scholia
  145. PARP1 poly(ADP-ribosyl)ates Sox2 to control Sox2 protein levels and FGF4 expression during embryonic stem cell differentiation. Gao F, Kwon SW, Zhao Y, Jin Y. J Biol Chem. 2009 Aug 14;284(33):22263–73. PubMed Europe PMC Scholia
  146. The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting. Donohoe ME, Silva SS, Pinter SF, Xu N, Lee JT. Nature. 2009 Jul 2;460(7251):128–32. PubMed Europe PMC Scholia
  147. The transcriptional foundation of pluripotency. Chambers I, Tomlinson SR. Development. 2009 Jul;136(14):2311–22. PubMed Europe PMC Scholia
  148. CARM1 is required in embryonic stem cells to maintain pluripotency and resist differentiation. Wu Q, Bruce AW, Jedrusik A, Ellis PD, Andrews RM, Langford CF, et al. Stem Cells. 2009 Nov;27(11):2637–45. PubMed Europe PMC Scholia
  149. Novel STAT3 target genes exert distinct roles in the inhibition of mesoderm and endoderm differentiation in cooperation with Nanog. Bourillot PY, Aksoy I, Schreiber V, Wianny F, Schulz H, Hummel O, et al. Stem Cells. 2009 Aug;27(8):1760–71. PubMed Europe PMC Scholia
  150. Trim24 targets endogenous p53 for degradation. Allton K, Jain AK, Herz HM, Tsai WW, Jung SY, Qin J, et al. Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11612–6. PubMed Europe PMC Scholia
  151. Cyclin-dependent kinase 2-associating protein 1 commits murine embryonic stem cell differentiation through retinoblastoma protein regulation. Kim Y, Deshpande A, Dai Y, Kim JJ, Lindgren A, Conway A, et al. J Biol Chem. 2009 Aug 28;284(35):23405–14. PubMed Europe PMC Scholia
  152. Cross-regulation of the Nanog and Cdx2 promoters. Chen L, Yabuuchi A, Eminli S, Takeuchi A, Lu CW, Hochedlinger K, et al. Cell Res. 2009 Sep;19(9):1052–61. PubMed Europe PMC Scholia
  153. Telomerase modulates Wnt signalling by association with target gene chromatin. Park JI, Venteicher AS, Hong JY, Choi J, Jun S, Shkreli M, et al. Nature. 2009 Jul 2;460(7251):66–72. PubMed Europe PMC Scholia
  154. A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells. Niwa H, Ogawa K, Shimosato D, Adachi K. Nature. 2009 Jul 2;460(7251):118–22. PubMed Europe PMC Scholia
  155. Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington’s canal. Hemberger M, Dean W, Reik W. Nat Rev Mol Cell Biol. 2009 Aug;10(8):526–37. PubMed Europe PMC Scholia
  156. Lsh participates in DNA methylation and silencing of stem cell genes. Xi S, Geiman TM, Briones V, Guang Tao Y, Xu H, Muegge K. Stem Cells. 2009 Nov;27(11):2691–702. PubMed Europe PMC Scholia
  157. The Ink4/Arf locus is a barrier for iPS cell reprogramming. Li H, Collado M, Villasante A, Strati K, Ortega S, Cañamero M, et al. Nature. 2009 Aug 27;460(7259):1136–9. PubMed Europe PMC Scholia
  158. Zfp206, Oct4, and Sox2 are integrated components of a transcriptional regulatory network in embryonic stem cells. Yu H bing, Kunarso G, Hong FH, Stanton LW. J Biol Chem. 2009 Nov 6;284(45):31327–35. PubMed Europe PMC Scholia
  159. The bHLH transcription factor Hand2 regulates the expression of nanog in ANS differentiation. Hashimoto Y, Myojin R, Katoh N, Ohtsu M, Tashiro F, Onoda F, et al. Biochem Biophys Res Commun. 2009 Dec 11;390(2):223–9. PubMed Europe PMC Scholia
  160. Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells. Meilinger D, Fellinger K, Bultmann S, Rothbauer U, Bonapace IM, Klinkert WEF, et al. EMBO Rep. 2009 Nov;10(11):1259–64. PubMed Europe PMC Scholia
  161. ERG-associated protein with SET domain (ESET)-Oct4 interaction regulates pluripotency and represses the trophectoderm lineage. Yeap LS, Hayashi K, Surani MA. Epigenetics Chromatin. 2009 Oct 7;2(1):12. PubMed Europe PMC Scholia
  162. Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming. Wei Z, Yang Y, Zhang P, Andrianakos R, Hasegawa K, Lyu J, et al. Stem Cells. 2009 Dec;27(12):2969–78. PubMed Europe PMC Scholia
  163. RNA polymerase II associated factor 1/PD2 maintains self-renewal by its interaction with Oct3/4 in mouse embryonic stem cells. Ponnusamy MP, Deb S, Dey P, Chakraborty S, Rachagani S, Senapati S, et al. Stem Cells. 2009 Dec;27(12):3001–11. PubMed Europe PMC Scholia
  164. Eset partners with Oct4 to restrict extraembryonic trophoblast lineage potential in embryonic stem cells. Yuan P, Han J, Guo G, Orlov YL, Huss M, Loh YH, et al. Genes Dev. 2009 Nov 1;23(21):2507–20. PubMed Europe PMC Scholia
  165. Mbd3, a component of NuRD/Mi-2 complex, helps maintain pluripotency of mouse embryonic stem cells by repressing trophectoderm differentiation. Zhu D, Fang J, Li Y, Zhang J. PLoS One. 2009 Nov 3;4(11):e7684. PubMed Europe PMC Scholia
  166. A novel signaling by vitamin A/retinol promotes self renewal of mouse embryonic stem cells by activating PI3K/Akt signaling pathway via insulin-like growth factor-1 receptor. Chen L, Khillan JS. Stem Cells. 2010 Jan;28(1):57–63. PubMed Europe PMC Scholia
  167. Hypoxia-inducible factors in stem cells and cancer. Mazumdar J, Dondeti V, Simon MC. J Cell Mol Med. 2009;13(11–12):4319–28. PubMed Europe PMC Scholia
  168. Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling. Gao S, Alarcón C, Sapkota G, Rahman S, Chen PY, Goerner N, et al. Mol Cell. 2009 Nov 13;36(3):457–68. PubMed Europe PMC Scholia
  169. Genome-wide mapping of SMAD target genes reveals the role of BMP signaling in embryonic stem cell fate determination. Fei T, Xia K, Li Z, Zhou B, Zhu S, Chen H, et al. Genome Res. 2010 Jan;20(1):36–44. PubMed Europe PMC Scholia
  170. Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression. Savarese F, Dávila A, Nechanitzky R, De La Rosa-Velazquez I, Pereira CF, Engelke R, et al. Genes Dev. 2009 Nov 15;23(22):2625–38. PubMed Europe PMC Scholia
  171. Oct4 and LIF/Stat3 additively induce Krüppel factors to sustain embryonic stem cell self-renewal. Hall J, Guo G, Wray J, Eyres I, Nichols J, Grotewold L, et al. Cell Stem Cell. 2009 Dec 4;5(6):597–609. PubMed Europe PMC Scholia
  172. Oct-4 controls cell-cycle progression of embryonic stem cells. Lee J, Go Y, Kang I, Han YM, Kim J. Biochem J. 2010 Feb 9;426(2):171–81. PubMed Europe PMC Scholia
  173. Wwp2 mediates Oct4 ubiquitination and its own auto-ubiquitination in a dosage-dependent manner. Liao B, Jin Y. Cell Res. 2010 Mar;20(3):332–44. PubMed Europe PMC Scholia
  174. Dissecting early differentially expressed genes in a mixture of differentiating embryonic stem cells. Hong F, Fang F, He X, Cao X, Chipperfield H, Xie D, et al. PLoS Comput Biol. 2009 Dec;5(12):e1000607. PubMed Europe PMC Scholia
  175. The cyclin-dependent kinase inhibitor p21 is a crucial target for histone deacetylase 1 as a regulator of cellular proliferation. Zupkovitz G, Grausenburger R, Brunmeir R, Senese S, Tischler J, Jurkin J, et al. Mol Cell Biol. 2010 Mar;30(5):1171–81. PubMed Europe PMC Scholia
  176. Kruppel-like factor 4 (Klf4) prevents embryonic stem (ES) cell differentiation by regulating Nanog gene expression. Zhang P, Andrianakos R, Yang Y, Liu C, Lu W. J Biol Chem. 2010 Mar 19;285(12):9180–9. PubMed Europe PMC Scholia
  177. JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Pasini D, Cloos PAC, Walfridsson J, Olsson L, Bukowski JP, Johansen JV, et al. Nature. 2010 Mar 11;464(7286):306–10. PubMed Europe PMC Scholia
  178. Stk40 links the pluripotency factor Oct4 to the Erk/MAPK pathway and controls extraembryonic endoderm differentiation. Li L, Sun L, Gao F, Jiang J, Yang Y, Li C, et al. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1402–7. PubMed Europe PMC Scholia
  179. The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells. Heng JCD, Feng B, Han J, Jiang J, Kraus P, Ng JH, et al. Cell Stem Cell. 2010 Feb 5;6(2):167–74. PubMed Europe PMC Scholia
  180. ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells. Wong LH, McGhie JD, Sim M, Anderson MA, Ahn S, Hannan RD, et al. Genome Res. 2010 Mar;20(3):351–60. PubMed Europe PMC Scholia
  181. Jarid2 and PRC2, partners in regulating gene expression. Li G, Margueron R, Ku M, Chambon P, Bernstein BE, Reinberg D. Genes Dev. 2010 Feb 15;24(4):368–80. PubMed Europe PMC Scholia
  182. Tbx3 improves the germ-line competency of induced pluripotent stem cells. Han J, Yuan P, Yang H, Zhang J, Soh BS, Li P, et al. Nature. 2010 Feb 25;463(7284):1096–100. PubMed Europe PMC Scholia
  183. Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation. Walker E, Chang WY, Hunkapiller J, Cagney G, Garcha K, Torchia J, et al. Cell Stem Cell. 2010 Feb 5;6(2):153–66. PubMed Europe PMC Scholia
  184. Caspase 3/caspase-activated DNase promote cell differentiation by inducing DNA strand breaks. Larsen BD, Rampalli S, Burns LE, Brunette S, Dilworth FJ, Megeney LA. Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4230–5. PubMed Europe PMC Scholia
  185. A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency. Mak AB, Ni Z, Hewel JA, Chen GI, Zhong G, Karamboulas K, et al. Mol Cell Proteomics. 2010 May;9(5):811–23. PubMed Europe PMC Scholia
  186. An expanded Oct4 interaction network: implications for stem cell biology, development, and disease. Pardo M, Lang B, Yu L, Prosser H, Bradley A, Babu MM, et al. Cell Stem Cell. 2010 Apr 2;6(4):382–95. PubMed Europe PMC Scholia
  187. A novel SALL4/OCT4 transcriptional feedback network for pluripotency of embryonic stem cells. Yang J, Gao C, Chai L, Ma Y. PLoS One. 2010 May 21;5(5):e10766. PubMed Europe PMC Scholia
  188. OCT3/4 regulates transcription of histone deacetylase 4 (Hdac4) in mouse embryonic stem cells. Addis RC, Prasad MK, Yochem RL, Zhan X, Sheets TP, Axelman J, et al. J Cell Biochem. 2010 Oct 1;111(2):391–401. PubMed Europe PMC Scholia
  189. TIF1beta regulates the pluripotency of embryonic stem cells in a phosphorylation-dependent manner. Seki Y, Kurisaki A, Watanabe-Susaki K, Nakajima Y, Nakanishi M, Arai Y, et al. Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):10926–31. PubMed Europe PMC Scholia
  190. Regulation of p53 in embryonic stem cells. Solozobova V, Blattner C. Exp Cell Res. 2010 Sep 10;316(15):2434–46. PubMed Europe PMC Scholia
  191. Phosphorylation stabilizes Nanog by promoting its interaction with Pin1. Moretto-Zita M, Jin H, Shen Z, Zhao T, Briggs SP, Xu Y. Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13312–7. PubMed Europe PMC Scholia
  192. Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Ito S, D’Alessio AC, Taranova OV, Hong K, Sowers LC, Zhang Y. Nature. 2010 Aug 26;466(7310):1129–33. PubMed Europe PMC Scholia
  193. Direct targets of Klf5 transcription factor contribute to the maintenance of mouse embryonic stem cell undifferentiated state. Parisi S, Cozzuto L, Tarantino C, Passaro F, Ciriello S, Aloia L, et al. BMC Biol. 2010 Sep 27;8:128. PubMed Europe PMC Scholia
  194. LRH-1 and Nanog regulate Dax1 transcription in mouse embryonic stem cells. Kelly VR, Hammer GD. Mol Cell Endocrinol. 2011 Jan 30;332(1–2):116–24. PubMed Europe PMC Scholia
  195. Dax1 up-regulates Oct4 expression in mouse embryonic stem cells via LRH-1 and SRA. Kelly VR, Xu B, Kuick R, Koenig RJ, Hammer GD. Mol Endocrinol. 2010 Dec;24(12):2281–91. PubMed Europe PMC Scholia