COVID-19 and endothelial cell senescence (WP5256)

Homo sapiens

Open in new tab Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
GABA SARS-CoV-2

Authors

Laure-Alix Clerbaux , Egon Willighagen , Eric Weitz , Denise Slenter , and John Figueira Hasbun

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

COVID-19

Annotations

Pathway Ontology

type I interferon signaling pathway signaling pathway

Disease Ontology

viral infectious disease COVID-19 severe acute respiratory syndrome

Participants
Query Drugst.One

Label Type Compact URI Comment
IL17RA GeneProduct ensembl:ENSG00000177663
ANO6 GeneProduct ensembl:ENSG00000177119
IL17A GeneProduct ensembl:ENSG00000112115
IL17RC GeneProduct ensembl:ENSG00000163702
TLR4 Protein uniprot:O00206
orf3a Protein uniprot:P0DTC3 PDB structure for SARS-CoV strain: 6JYT
orf8 Protein uniprot:P0DTC8 PDB structure for SARS-CoV strain: 6JYT
nsp4 Protein uniprot:PRO_0000449622 PDB structure for SARS-CoV strain: 6JYT; PRO_0000449622

References

  1. Viral Mimicry of Interleukin-17A by SARS-CoV-2 ORF8. Wu X, Xia T, Shin WJ, Yu KM, Jung W, Herrmann A, et al. mBio. 2022 Apr 26;13(2):e0040222. PubMed Europe PMC Scholia