Statin pathway (WP1041)

Bos taurus

Open in new tab Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
Statins inhibit endogenous cholesterol production by competitive inhibition of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol synthesis. This pathway delineates genes involved in statin pharmacogenomics, including genes involved in mediating the effects of statins on plasma lipoprotein metabolism. Sources: [https://www.pharmgkb.org/do/serve?objId=PA2031&objCls=Pathway PharmGKB] and [http://en.wikipedia.org/wiki/Statin Wikipedia]

Authors

Thomas Kelder , Alex Pico , Daniela Digles , Martina Summer-Kutmon , Egon Willighagen , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Bos taurus

Communities

Annotations

Cell Type Ontology

enterocyte hepatocyte

Pathway Ontology

statin drug pathway

Disease Ontology

cardiovascular system disease

Participants

Label Type Compact URI Comment
Cholesterol Metabolite cas:57-88-5
Squalene Metabolite hmdb:HMDB0000256
Acyl-CoA Metabolite hmdb:HMDB0003419
Phospholipid Metabolite kegg.compound:C00865
DAG Metabolite kegg.compound:C00165
VLDL Metabolite chebi:39027
Cholesterol ester Metabolite kegg.compound:C02530
Statin Metabolite chebi:87631
Acetyl-CoA Metabolite hmdb:HMDB0001206
IDL Metabolite kegg.compound:C01834
Lipoproteins Metabolite chebi:6495
Mevalonate Metabolite chebi:25350
HDL Metabolite chebi:39025
Fatty acid Metabolite kegg.compound:C00162
Cholic Acid Metabolite cas:81-25-4
LDL Metabolite chebi:39026
Triglyceride Metabolite kegg.compound:C00422
ABCA1 GeneProduct ensembl:ENSBTAG00000020661 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:19
ABCG8 GeneProduct ensembl:ENSBTAG00000016366 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64241
APOA1 GeneProduct ensembl:ENSBTAG00000002258 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:335
APOA4 GeneProduct ensembl:ENSBTAG00000019770 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:337
bta-mir-33a GeneProduct ensembl:ENSBTAG00000029975 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207932
APOC3 GeneProduct ensembl:ENSBTAG00000012398 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:345
APOA5 GeneProduct ensembl:ENSBTAG00000019764 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:116519
CYP7A1 GeneProduct ensembl:ENSBTAG00000005287 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1581
SCARB1 GeneProduct ensembl:ENSBTAG00000014269 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:949
PLTP GeneProduct ensembl:ENSBTAG00000000559 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5360
ABCG5 GeneProduct ensembl:ENSBTAG00000016365 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64240
APOA2 GeneProduct ensembl:ENSBTAG00000009212 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:336
LCAT GeneProduct ensembl:ENSBTAG00000018043 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3931
LDLR GeneProduct ensembl:ENSBTAG00000012314 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3949
APOB GeneProduct ensembl:ENSBTAG00000008505 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:338
DGAT1 GeneProduct ensembl:ENSBTAG00000026356 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8694
LPL GeneProduct ensembl:ENSBTAG00000012855 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4023
bta-mir-33b GeneProduct ensembl:ENSBTAG00000036437 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207839
SQLE GeneProduct ensembl:ENSBTAG00000005498 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6713
LIPC GeneProduct ensembl:ENSBTAG00000005479 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3990
SOAT1 GeneProduct ensembl:ENSBTAG00000004059 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6646
APOE GeneProduct ensembl:ENSBTAG00000010123 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:348
LRP1 GeneProduct ensembl:ENSBTAG00000010830 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4035
FDFT1 GeneProduct ensembl:ENSBTAG00000012432 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2222
HMGCR GeneProduct ensembl:ENSBTAG00000007840 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3156
PDIA2 Protein ensembl:ENSBTAG00000016575 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64714
ACSS1 Protein ensembl:ENSBTAG00000004281 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84532
MTTP Protein ensembl:ENSBTAG00000011944 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4547

References

  1. Microsomal triglyceride transfer protein. Wetterau JR, Lin MC, Jamil H. Biochim Biophys Acta. 1997 Apr 1;1345(2):136–50. PubMed Europe PMC Scholia
  2. Direct effects of statins on cells primarily involved in atherosclerosis. Chen H, Ikeda U, Shimpo M, Shimada K. Hypertens Res. 2000 Mar;23(2):187–92. PubMed Europe PMC Scholia