Asparagine degradation (WP432)

Saccharomyces cerevisiae

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Like many other amino acids, asparagine may be utilized by S. cerevisiae as a sole source of nitrogen. Catabolism of asparagine for nitrogen involves the action of asparaginases, which hydrolyze the amide group in the side chain of asparagine. This converts asparagine to aspartate and releases an assimilable molecule of ammonia (NH3). Further nitrogen can be derived from the newly generated aspartate molecule via its reversible conversion to glutamate by aspartate aminotransferases. Glutamate, whose amino group can be hydrolyzed to release ammonia, represents one of the major sources of nitrogen for biosynthetic reactions in S. cerevisiae. SOURCE: SGD pathways, http://pathway.yeastgenome.org/server.html

Authors

Jessica Heckman , Martina Summer-Kutmon , Christine Chichester , and Kristina Hanspers

Activity

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Organisms

Saccharomyces cerevisiae

Communities

Annotations

Pathway Ontology

asparagine metabolic pathway

Participants

Label Type Compact URI Comment
NH3 Metabolite chebi:28938
H2O Metabolite chebi:15377
oxaloacetic acid Metabolite chebi:16452
L-aspartate Metabolite chebi:29991
2-oxoglutarate Metabolite chebi:16810
L-glutamate Metabolite cas:56-86-0
L-asparagine Metabolite cas:70-47-3
ASP1 GeneProduct sgd:S000002729
ASP3-1 GeneProduct sgd:S000004145
AAT2 GeneProduct sgd:S000004017
ASP3-3 GeneProduct sgd:S000004148
ASP3-4 GeneProduct sgd:S000004150
ASP3-2 GeneProduct sgd:S000004147
AAT1 GeneProduct sgd:S000001589

References

  1. The role of ammonia metabolism in nitrogen catabolite repression in Saccharomyces cerevisiae. ter Schure EG, van Riel NA, Verrips CT. FEMS Microbiol Rev. 2000 Jan;24(1):67–83. PubMed Europe PMC Scholia
  2. URL: https://pathway.yeastgenome.org/YEAST/NEW-IMAGE?type=PATHWAY&object=ASPARAGINE-DEG2-PWY