Leptin and adiponectin

Thomas Kelder; WikiPathways Maintenance bot; Egon Willighagen

Leptin and adiponectin (WP683)

Mus musculus

Proposed mechanism by which leptin and adiponectin stimulate fatty acid oxidation. Adapted from fig 1 in [http://www.ncbi.nlm.nih.gov/pubmed/16497175 Dyck et al.].

Authors

Thomas Kelder and Egon Willighagen

Activity

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Cited In

Advanced Running Performance by Genetic Predisposition in Male Dummerstorf Marathon Mice (DUhTP) Reveals Higher Sterol Regulatory Element-Binding Protein (SREBP) Related mRNA Expression in the Liver and Higher Serum Levels of Progesterone (2016).

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Organisms

Mus musculus

Communities

Annotations

Disease Ontology

glucose metabolism disease

Pathway Ontology

leptin system pathway adiponectin signaling pathway

Participants

Label	Type	Compact URI
Fatty acid	Metabolite	chebi:35366
Fatty acid	Metabolite	chebi:35366
Acetyl-CoA	Metabolite	chebi:15351
Malonyl-CoA	Metabolite	chebi:15531
Adipor1	GeneProduct	ncbigene:72674
Prkaa1	GeneProduct	ncbigene:105787
Prkab1	GeneProduct	ncbigene:19079
Leptin	GeneProduct	ncbigene:16846
Adipor2	GeneProduct	ncbigene:68465
Acc1	GeneProduct	ncbigene:107476
Prkag1	GeneProduct	ncbigene:19082
Lepr	GeneProduct	ncbigene:16847
Cpt1	GeneProduct	ncbigene:12894
Adiponectin	GeneProduct	ncbigene:11450

References

The role of adipokines as regulators of skeletal muscle fatty acid metabolism and insulin sensitivity. Dyck DJ, Heigenhauser GJF, Bruce CR. Acta Physiol (Oxf). 2006 Jan;186(1):5–16. PubMed Europe PMC Scholia