Transcription factor regulation in adipogenesis (WP3599)

Homo sapiens

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The transcription factors involved in adipogenesis are shown in the current pathway. Adipogensis is the biological proces of cell differentation in which preadipocytes are converted into adipocytes. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3599 CPTAC Assay Portal].

Authors

Ingrid Felicidade , Susan Coort , Martina Summer-Kutmon , Kristina Hanspers , Egon Willighagen , and Friederike Ehrhart

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Cell Type Ontology

fat cell

Pathway Ontology

signaling pathway pertinent to development

Participants
Query Drugst.One

Label Type Compact URI Comment
Glucocorticoids Metabolite chebi:24261
INSR GeneProduct ensembl:ENSG00000171105
RXRA GeneProduct ensembl:ENSG00000186350
LPIN1 GeneProduct ensembl:ENSG00000134324
PCK2 GeneProduct ensembl:ENSG00000100889
CEBPA GeneProduct ensembl:ENSG00000245848
GLUT4 GeneProduct ensembl:ENSG00000181856
PPARG GeneProduct ensembl:ENSG00000132170
CREB1 GeneProduct ensembl:ENSG00000118260
CEBPB GeneProduct ensembl:ENSG00000172216
CEBPD GeneProduct ensembl:ENSG00000221869
NR3C1 GeneProduct ensembl:ENSG00000113580
NRIP1 GeneProduct ensembl:ENSG00000180530
IRS1 GeneProduct ensembl:ENSG00000169047
IRS2 GeneProduct ensembl:ENSG00000185950
ADIPOQ GeneProduct ensembl:ENSG00000181092
LEP GeneProduct ensembl:ENSG00000174697
JNK GeneProduct ensembl:ENSG00000107643
FOXO1A GeneProduct ensembl:ENSG00000150907
TWIST1 GeneProduct ensembl:ENSG00000122691
PPARGC1A GeneProduct ensembl:ENSG00000109819
TNF GeneProduct ensembl:ENSG00000232810
IL6 GeneProduct ensembl:ENSG00000136244

References

  1. PPAR gamma 2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene. Tontonoz P, Hu E, Devine J, Beale EG, Spiegelman BM. Mol Cell Biol. 1995 Jan;15(1):351–7. PubMed Europe PMC Scholia
  2. Regulation of cytosolic phosphoenolpyruvate carboxykinase gene expression in adipocytes. Beale EG, Forest C, Hammer RE. Biochimie. 2003 Dec;85(12):1207–11. PubMed Europe PMC Scholia
  3. Inflammation and metabolic disorders. Hotamisligil GS. Nature. 2006 Dec 14;444(7121):860–7. PubMed Europe PMC Scholia
  4. Lpin1 in human visceral and subcutaneous adipose tissue: similar levels but different associations with lipogenic and lipolytic genes. Miranda M, Escoté X, Alcaide MJ, Solano E, Ceperuelo-Mallafré V, Hernández P, et al. Am J Physiol Endocrinol Metab. 2010 Aug;299(2):E308-17. PubMed Europe PMC Scholia
  5. Role of nuclear receptor corepressor RIP140 in metabolic syndrome. Rosell M, Jones MC, Parker MG. Biochim Biophys Acta. 2011 Aug;1812(8):919–28. PubMed Europe PMC Scholia
  6. Adipogenesis at a glance. Lowe CE, O’Rahilly S, Rochford JJ. J Cell Sci. 2011 Aug 15;124(Pt 16):2681–6. PubMed Europe PMC Scholia
  7. Transcriptional networks and chromatin remodeling controlling adipogenesis. Siersbæk R, Nielsen R, Mandrup S. Trends Endocrinol Metab. 2012 Feb;23(2):56–64. PubMed Europe PMC Scholia
  8. A tale with a Twist: a developmental gene with potential relevance for metabolic dysfunction and inflammation in adipose tissue. Dobrian AD. Front Endocrinol (Lausanne). 2012 Aug 30;3:108. PubMed Europe PMC Scholia