Glucocorticoid receptor pathway (WP2880)

Homo sapiens

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The glucocorticoid receptor (GR, a.k.a. NR3C1) is a nuclear receptor that is activated upon binding of cortisol or glucocorticoids. It mainly regulates gene expression of several groups of genes in two ways. It can stimulate anti-inflammatory genes, or inhibit the transcription of pro-inflammatory genes.

Authors

Rianne Fijten , Kristina Hanspers , Friederike Ehrhart , Egon Willighagen , Alex Pico , and Eric Weitz

Activity

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

glucocorticoid signaling pathway signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
GR ligand Metabolite chebi:63562
Ligand Metabolite chebi:63562
Ligand Metabolite chebi:63562
Ligand Metabolite chebi:63562
Ligand Metabolite chebi:63562
Ligand Metabolite chebi:63562
Ligand Metabolite chebi:63562
Ligand Metabolite chebi:63562
Ligand Metabolite chebi:63562
JUN GeneProduct ncbigene:3725 jun proto-oncogene
NR3C1 GeneProduct ncbigene:2908 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NFKB2 GeneProduct ncbigene:4791 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NR3C1 GeneProduct ncbigene:2908 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR3C1 GeneProduct ncbigene:2908 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
HSP90AA1 GeneProduct ncbigene:3320 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AA1 GeneProduct ncbigene:3320 heat shock protein 90kDa alpha (cytosolic), class A member 1
NR3C1 GeneProduct ncbigene:2908 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
HSP90AA1 GeneProduct ncbigene:3320 heat shock protein 90kDa alpha (cytosolic), class A member 1
NR3C1 GeneProduct ncbigene:2908 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR3C1 GeneProduct ncbigene:2908 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR3C1 GeneProduct ncbigene:2908 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR3C1 GeneProduct ncbigene:2908 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR3C1 GeneProduct ncbigene:2908 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR3C1 GeneProduct ncbigene:2908 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PTGES3 GeneProduct ncbigene:10728 prostaglandin E synthase 3 (cytosolic)
PTGES3 GeneProduct ncbigene:10728 prostaglandin E synthase 3 (cytosolic)
PTGES3 GeneProduct ncbigene:10728 prostaglandin E synthase 3 (cytosolic)
BHLHE40 GeneProduct ncbigene:8553 basic helix-loop-helix family, member e40
NAV3 GeneProduct ncbigene:89795 neuron navigator 3
IL11 GeneProduct ncbigene:3589 interleukin 11
AMIGO2 GeneProduct ncbigene:347902 adhesion molecule with Ig-like domain 2
SERTAD2 GeneProduct ncbigene:9792 SERTA domain containing 2
ARL5B GeneProduct ncbigene:221079 ADP-ribosylation factor-like 5B
CXCR7 GeneProduct ncbigene:57007 atypical chemokine receptor 3
CUL1 GeneProduct ncbigene:8454 cullin 1
FGFBP1 GeneProduct ncbigene:9982 fibroblast growth factor binding protein 1
KTN1 GeneProduct ncbigene:3895 kinectin 1 (kinesin receptor)
SERPINB9 GeneProduct ncbigene:5272 serpin peptidase inhibitor, clade B (ovalbumin), member 9
CCL2 GeneProduct ncbigene:6347 chemokine (C-C motif) ligand 2
ENC1 GeneProduct ncbigene:8507 ectodermal-neural cortex 1 (with BTB domain)
PTGS2 GeneProduct ncbigene:5743 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
ZIC2 GeneProduct ncbigene:7546 Zic family member 2
PMP2 GeneProduct ncbigene:5375 peripheral myelin protein 2
PDE4B GeneProduct ncbigene:5142 phosphodiesterase 4B, cAMP-specific
PLK2 GeneProduct ncbigene:10769 polo-like kinase 2
CCL20 GeneProduct ncbigene:6364 chemokine (C-C motif) ligand 20
EDN2 GeneProduct ncbigene:1907 endothelin 2
MGAM GeneProduct ncbigene:8972 maltase-glucoamylase
RGS2 GeneProduct ncbigene:5997 regulator of G-protein signaling 2
ALOX5AP GeneProduct ncbigene:241 arachidonate 5-lipoxygenase-activating protein
TSC22D3 GeneProduct ncbigene:1831 TSC22 domain family, member 3
CDC42EP3 GeneProduct ncbigene:10602 CDC42 effector protein (Rho GTPase binding) 3
SNAI2 GeneProduct ncbigene:6591 snail family zinc finger 2
BIRC3 GeneProduct ncbigene:330 baculoviral IAP repeat containing 3
SPINK13 GeneProduct ncbigene:153218 serine peptidase inhibitor, Kazal type 13 (putative)
SPRY1 GeneProduct ncbigene:10252 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
GADD45B GeneProduct ncbigene:4616 growth arrest and DNA-damage-inducible, beta
PRRG4 GeneProduct ncbigene:79056 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
FGD4 GeneProduct ncbigene:121512 FYVE, RhoGEF and PH domain containing 4
SLC26A2 GeneProduct ncbigene:1836 solute carrier family 26 (anion exchanger), member 2
EPB41L4B GeneProduct ncbigene:54566 erythrocyte membrane protein band 4.1 like 4B
GPR115 GeneProduct ncbigene:221393 adhesion G protein-coupled receptor F4
PPP1R14C GeneProduct ncbigene:81706 protein phosphatase 1, regulatory (inhibitor) subunit 14C
BIRC2 GeneProduct ncbigene:329 baculoviral IAP repeat containing 2
GPR153 GeneProduct ncbigene:387509 G protein-coupled receptor 153
TGFBR3 GeneProduct ncbigene:7049 transforming growth factor, beta receptor III
ANGPTL4 GeneProduct ncbigene:51129 angiopoietin-like 4
LRRC8A GeneProduct ncbigene:56262 leucine rich repeat containing 8 family, member A
ANKRD1 GeneProduct ncbigene:27063 ankyrin repeat domain 1 (cardiac muscle)
THBD GeneProduct ncbigene:7056 thrombomodulin
CDKN1C GeneProduct ncbigene:1028 cyclin-dependent kinase inhibitor 1C (p57, Kip2)
SCNN1A GeneProduct ncbigene:6337 sodium channel, non voltage gated 1 alpha subunit
SLC19A2 GeneProduct ncbigene:10560 solute carrier family 19 (thiamine transporter), member 2
TNFAIP3 GeneProduct ncbigene:7128 tumor necrosis factor, alpha-induced protein 3
SRGN GeneProduct ncbigene:5552 serglycin
STOM GeneProduct ncbigene:2040 stomatin
SEC14L1 GeneProduct ncbigene:6397 SEC14-like 1 (S. cerevisiae)
DNAJC15 GeneProduct ncbigene:29103 DnaJ (Hsp40) homolog, subfamily C, member 15
DNER GeneProduct ncbigene:92737 delta/notch-like EGF repeat containing
MFGE8 GeneProduct ncbigene:4240 milk fat globule-EGF factor 8 protein
ABHD2 GeneProduct ncbigene:11057 abhydrolase domain containing 2
CPEB4 GeneProduct ncbigene:80315 cytoplasmic polyadenylation element binding protein 4
SDPR GeneProduct ncbigene:8436 serum deprivation response
MT1IP GeneProduct ncbigene:644314 metallothionein 1I, pseudogene
ETNK2 GeneProduct ncbigene:55224 ethanolamine kinase 2
B3GNT5 GeneProduct ncbigene:84002 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
AKAP13 GeneProduct ncbigene:11214 A kinase (PRKA) anchor protein 13
POU5F1 GeneProduct ncbigene:5460 POU class 5 homeobox 1
TNS4 GeneProduct ncbigene:84951 tensin 4
S100P GeneProduct ncbigene:6286 S100 calcium binding protein P
NR1I3 GeneProduct ncbigene:9970 nuclear receptor subfamily 1, group I, member 3
NR1I2 GeneProduct ncbigene:8856 nuclear receptor subfamily 1, group I, member 2
RXRA GeneProduct ncbigene:6256 retinoid X receptor, alpha

References

  1. The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways. Cai Y, Konishi T, Han G, Campwala KH, French SW, Wan YJY. Eur J Pharm Sci. 2002 Feb;15(1):89–96. PubMed Europe PMC Scholia
  2. The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors. Pascussi JM, Gerbal-Chaloin S, Drocourt L, Maurel P, Vilarem MJ. Biochim Biophys Acta. 2003 Feb 17;1619(3):243–53. PubMed Europe PMC Scholia
  3. Chromatin immunoprecipitation (ChIP) scanning identifies primary glucocorticoid receptor target genes. Wang JC, Derynck MK, Nonaka DF, Khodabakhsh DB, Haqq C, Yamamoto KR. Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15603–8. PubMed Europe PMC Scholia
  4. Mechanisms of glucocorticoid receptor signaling during inflammation. Smoak KA, Cidlowski JA. Mech Ageing Dev. 2004;125(10–11):697–706. PubMed Europe PMC Scholia
  5. A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer. Xu RX, Lambert MH, Wisely BB, Warren EN, Weinert EE, Waitt GM, et al. Mol Cell. 2004 Dec 22;16(6):919–28. PubMed Europe PMC Scholia
  6. Pathways for ligand activated nuclear receptors to unravel the genomic responses induced by hepatotoxicants. Fijten RRR, Jennen DGJ, van Delft JHM. Curr Drug Metab. 2013 Dec;14(10):1022–8. PubMed Europe PMC Scholia