Regulation of cardiac hypertrophy by miR-208 (WP1526)

Mus musculus

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MicroRNA-208a regulates cardiac hypertrophy pathways in mice. MicroRNAs are shown in purple. Knock out and overexpression of miR-208a are shown in blue. Processes are shown at the top and include hypertrophy, atrial fibrilation and prolonged PR interval & abberand conduction.

Authors

Maartje Levels , Susan Coort , Martina Summer-Kutmon , Kristina Hanspers , Linda Rieswijk , Eric Weitz , and Egon Willighagen

Activity

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

hypertrophic cardiomyopathy pathway

Participants

Label Type Compact URI Comment
Gata4 GeneProduct ncbigene:14463
beta-MHC GeneProduct ncbigene:140781
Hop GeneProduct ncbigene:74318
Trap1 Protein ncbigene:327987
Cx40 Protein ncbigene:14613
Myostatin Protein ncbigene:17700

References

  1. Role of gap junctions in cardiac conduction and development: insights from the connexin knockout mice. Lo CW. Circ Res. 2000 Sep 1;87(5):346–8. PubMed Europe PMC Scholia
  2. MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice. Callis TE, Pandya K, Seok HY, Tang RH, Tatsuguchi M, Huang ZP, et al. J Clin Invest. 2009 Sep;119(9):2772–86. PubMed Europe PMC Scholia