RTK/Ras/MAPK - LET-23, EGL-15 independent (WP2569)

Caenorhabditis elegans

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This pathway represents the core elements of Receptor Tyrosine Kinase (RTK)/Ras GTPase/MAP kinase (MAPK) pathways. Many developmental events in C. elegans require this signaling pathway with different RTK's providing activation of the pathway in specific cell-types and under different regulatory controls. Depending on the process, this signaling pathway may interact with the Wnt, Notch, or other pathways during development.

Authors

Karen Yook and Egon Willighagen

Activity

last edited

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Cited In

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Organisms

Caenorhabditis elegans

Communities

WormBase

Annotations

Pathway Ontology

the extracellular signal-regulated Raf/Mek/Erk signaling pathway Ras mediated signaling pathway

Participants

Label Type Compact URI Comment
GTP Metabolite chebi:15996
KSR-2 GeneProduct ensembl:WBGene00002240
LIN-39 GeneProduct ensembl:WBGene00003024
SEM-4 GeneProduct ensembl:WBGene00004773
LST-2 GeneProduct ensembl:WBGene00003084
VAB-1 GeneProduct ensembl:WBGene00006868
EGL-19 GeneProduct ensembl:WBGene00001187
CNK-1 GeneProduct ensembl:WBGene00000564
ROM-1 GeneProduct ensembl:WBGene00004400
DAB-1 GeneProduct ensembl:WBGene00000894
EGL-18 GeneProduct ensembl:WBGene00001186
LIN-2 GeneProduct ensembl:WBGene00002991
LIN-35 GeneProduct ensembl:WBGene00003020
SUR-2 GeneProduct ensembl:WBGene00006349
LIN-45/Raf GeneProduct ensembl:WBGene00003030
DPY-22 GeneProduct ensembl:WBGene00001081
EGL-30 GeneProduct ensembl:WBGene00001196
ELT-6 GeneProduct ensembl:WBGene00001253
ARK-1 GeneProduct ensembl:WBGene00000186
EGL-15 GeneProduct ensembl:WBGene00001184
LIN-7 GeneProduct ensembl:WBGene00002996
CLR-1 GeneProduct ensembl:WBGene00000548
LIN-25 GeneProduct ensembl:WBGene00003011
LIN-10 GeneProduct ensembl:WBGene00002999
LRP-1 GeneProduct ensembl:WBGene00003071
SOC-2 GeneProduct ensembl:WBGene00004929
SEM-5 GeneProduct ensembl:WBGene00004774
PAR-1 GeneProduct ensembl:WBGene00003916
SUR-7 GeneProduct ensembl:WBGene00006353
LRP-2 GeneProduct ensembl:WBGene00003072
LIP-1 GeneProduct ensembl:WBGene00003043
PTP-2 GeneProduct ensembl:WBGene00004214
EOR-2 GeneProduct ensembl:WBGene00001325
SUR-5 GeneProduct ensembl:WBGene00006351
LIN-12 GeneProduct ensembl:WBGene00003001
LST-3 GeneProduct ensembl:WBGene00003085
LST-1 GeneProduct ensembl:WBGene00003083
EFL-1 GeneProduct ensembl:WBGene00001161
GAP-1 GeneProduct ensembl:WBGene00001515
GAP-2 GeneProduct ensembl:WBGene00001516
LIN-31 GeneProduct ensembl:WBGene00003017
SLI-1 GeneProduct ensembl:WBGene00004829
LIN-1 GeneProduct ensembl:WBGene00002990
MPK-1/Erk GeneProduct ensembl:WBGene00003401
LET-756 GeneProduct ensembl:WBGene00002881
SOC-1 GeneProduct ensembl:WBGene00004928
EGL-17 GeneProduct ensembl:WBGene00001185
SOS-1/GEF GeneProduct ensembl:WBGene00004947
EGL-5 GeneProduct ensembl:WBGene00001174
LST-4 GeneProduct ensembl:WBGene00003086
DAF-2 GeneProduct ensembl:WBGene00000898
UNC-101 GeneProduct ensembl:WBGene00006829
EOR-1 GeneProduct ensembl:WBGene00001324
MEK-2/Mek GeneProduct ensembl:WBGene00003186
CDF-1 GeneProduct ensembl:WBGene00000393
KSR-1 GeneProduct ensembl:WBGene00002239
SUR-6 GeneProduct ensembl:WBGene00006352
GPA-5 GeneProduct ensembl:WBGene00001667
LET-60/Ras GeneProduct ensembl:WBGene00002335
LIN-3 GeneProduct ensembl:WBGene00002992
LET-23 GeneProduct ensembl:WBGene00002299
DPY-23 GeneProduct ensembl:WBGene00001082
SRA-13 GeneProduct ensembl:WBGene00005039
LET-92 GeneProduct ensembl:WBGene00002363

References

  1. RTK/Ras/MAPK signaling. Sundaram MV. WormBook. 2006 Feb 11;1–19. PubMed Europe PMC Scholia