Fatty acid biosynthesis, initial steps (WP137)

Pyridoxal phosphate (PLP) is the active form of vitamin B₆ and is a cofactor in many reactions of amino acid metabolism. Pyridoxine (PN), pyridoxamine (PM), pyridoxal (PL), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP) are all forms of vitamin B₆ that can be converted to PLP via the PLP salvage pathway. Most unicellular organisms and plants can synthesize PLP, whereas mammals cannot and require vitamin B₆ in their diet. Thus far, three PLP biosynthetic pathways have been characterized: the de novo PLP biosynthesis pathway as characterized in Escherichia coli (CITS: [12686115]), the de novo PLP biosynthesis pathway as being studied in fungi (CITS: [15483325],[14764090]), and the PLP salvage pathway (CITS: [15483325], [17696614],[8764513],[9537380]). Saccharomyces cerevisiae synthesize PLP via the fungal type de novo PLP synthesis pathway and the PLP salvage pathway (CITS: [7896706], [17696614], [15483325], [14764090]). Extracellular PN, PL and PM are transported into the cell by Tpn1p, a member of the purine-cytosine permease family (CITS: [12649274]). SOURCE: SGD pathways, http://pathway.yeastgenome.org/server.html

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