Metastatic brain tumor (WP2249)

Homo sapiens

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Interaction between microRNAs (miRNAs) and abnormal methylation to control metastasis. Tumor growth and metastasis formation through down regulation of their oncogenic targets such as MYC, E2F3 and cyclin-dependent kinase(CDK6). Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2249 CPTAC Assay Portal]

Authors

Devi , Egon Willighagen , Kristina Hanspers , Elisa Cirillo , and Martina Summer-Kutmon

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Diseases ExRNA

Annotations

Pathway Ontology

disease pathway

Disease Ontology

disease of cellular proliferation

Participants
Query Drugst.One

Label Type Compact URI Comment
E2F3 GeneProduct ensembl:ENSG00000112242
TP53 GeneProduct ensembl:ENSG00000141510
CDC42 GeneProduct ensembl:ENSG00000070831
MIR29A GeneProduct ensembl:ENSG00000284033
CDK6 GeneProduct ensembl:ENSG00000105810
MYC GeneProduct ensembl:ENSG00000136997
MIRLET7A1 GeneProduct ensembl:ENSG00000199165
MIR29C GeneProduct ensembl:ENSG00000284214
MIRLET7A3 GeneProduct ensembl:ENSG00000198986
MIRLET7C GeneProduct ensembl:ENSG00000199030
MIRLET7D GeneProduct ensembl:ENSG00000199133
MIRLET7E GeneProduct ensembl:ENSG00000198972
MIRLET7F1 GeneProduct ensembl:ENSG00000199072
MIRLET7G GeneProduct ensembl:ENSG00000199150
P85A_HUMAN Protein uniprot:P27986

References

  1. miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42. Park SY, Lee JH, Ha M, Nam JW, Kim VN. Nat Struct Mol Biol. 2009 Jan;16(1):23–9. PubMed Europe PMC Scholia
  2. The miR-34 family in cancer and apoptosis. Hermeking H. Cell Death Differ. 2010 Feb;17(2):193–9. PubMed Europe PMC Scholia
  3. p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC. Christoffersen NR, Shalgi R, Frankel LB, Leucci E, Lees M, Klausen M, et al. Cell Death Differ. 2010 Feb;17(2):236–45. PubMed Europe PMC Scholia
  4. Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. Hafner M, Landthaler M, Burger L, Khorshid M, Hausser J, Berninger P, et al. Cell. 2010 Apr 2;141(1):129–41. PubMed Europe PMC Scholia