CCL18 signaling (WP5097)

Homo sapiens

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A multi-cellular molecular signaling and functional network map of C-C Motif Chemokine Ligand 18 (CCL18): A chemokine with immunosuppressive and pro-tumor function

Authors

Dr. T. S. Keshava Prasad , Egon Willighagen , Eric Weitz , and Alex Pico

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

CPTAC

Annotations

Pathway Ontology

signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Ca++ Metabolite pubchem.substance:271
PIP2 Metabolite chebi:37328
Histamine Metabolite chebi:18295
AKT1 GeneProduct refseq:NP_005154.2
ASAP3 Protein refseq:NP_060177.2
EZR Protein refseq:NP_003370.2
CCR6 Protein refseq:NP_004358.2
GSK3B Protein refseq:NP_002084.2
PLCG1 Protein refseq:NP_002651.2
PITPNM3 Protein refseq:NP_112497.2
CCR8 Protein refseq:NP_005192.1
VIM Protein refseq:NP_003371.2
CDH5 Protein refseq:NP_001786.2
CDH1 Protein refseq:NP_004351.1
MAPK3 Protein refseq:NP_002737.2
CHUK Protein refseq:NP_001269.3
MAPK1 Protein refseq:NP_002736.3
STAT3 Protein refseq:NP_003141.2
CDH2 Protein ncbigene:1000
FN1 Protein refseq:NP_002017.2
PRKCZ Protein refseq:NP_002735.3
ITPKB Protein refseq:NP_002212.3
PTK2B Protein refseq:NP_004094.3
SRC Protein refseq:NP_005408.1
PTK2 Protein refseq:NP_005598.3
ITGA5 Protein refseq:NP_002196.4
ITGB1 Protein refseq:NP_002202.2
ANXA2 Protein refseq:NP_004030.1
GPER1 Protein refseq:NP_001496.1
VCAM1 Protein refseq:NP_001069.1
RELA Protein refseq:NP_068810.3
ZEB2 Protein ncbigene:9839
JAK2 Protein refseq:NP_004963.1
MTDH Protein refseq:NP_848927.2
NFKBIA Protein refseq:NP_065390.1
MMP2 Protein ncbigene:4313
EP300 Protein refseq:NP_001420.2
IKBKB Protein refseq:NP_001547.1
ARF6 Protein refseq:NP_001654.1
IKBKG Protein refseq:NP_003630.1
KAT2B Protein refseq:NP_003875.3
ASAP1 Protein refseq:NP_060952.2
MMP3 Protein refseq:NP_002413.1
SNAI2 Protein refseq:NP_003059.1
PTK2B Protein ncbigene:2185
KITLG Protein refseq:NP_000890.1
CXCL8 Protein refseq:NP_000575.1
CASP8 Protein refseq:NP_001219.2
VEGFA Protein refseq:NP_003367.4
TIMP1 Protein refseq:NP_003245.1
IL6 Protein refseq:NP_000591.1
CCR8 Protein ncbigene:1237
NRAS Protein refseq:NP_002515.1
LIN28B Protein refseq:NP_001004317.1
SNAI1 Protein refseq:NP_005976.2
SP1 Protein refseq:NP_003100.1
SMAD2 Protein refseq:NP_005892.1
SMAD3 Protein refseq:NP_005893.1
COL1A1 Protein refseq:NP_000079.2
IL15 Protein refseq:NP_751915.1
CCL2 Protein refseq:NP_002973.1
CCL3 Protein refseq:NP_002974.1
TIMP2 Protein refseq:NP_003246.1
TGFB1 Protein refseq:NP_000651.3
FGF2 Protein refseq:NP_001997.5
MAD1L1 Protein refseq:NP_003541.2
CREB1 Protein refseq:NP_004370.1
FOS Protein refseq:NP_005243.1
MAPK8 Protein refseq:NP_620634.1
MAPK9 Protein refseq:NP_002743.3
ELMO1 Protein refseq:NP_055615.8
CXCR4 Protein refseq:NP_003458.1
MTOR Protein refseq:NP_004949.1
ACTA2 Protein refseq:NP_001604.1
PRKCA Protein refseq:NP_002728.2
COL1A2 Protein refseq:NP_000080.2
CCR3 Protein refseq:NP_001828.1
CCR1 Protein refseq:NP_001286.1
CCR2 Protein refseq:NP_001116868.1
CCR4 Protein refseq:NP_005499.1
CCR5 Protein refseq:NP_000570.1
RAC1 Protein refseq:NP_002924.1
POU5F1 Protein refseq:NP_002692.2
BMI1 Protein refseq:NP_005171.4
PRKCD Protein refseq:NP_006245.2
KIF5B Protein refseq:NP_004512.1
LIN28A Protein refseq:NP_078950.1
TWIST1 Protein refseq:NP_000465.1
ZEB1 Protein refseq:NP_110378.3
ZEB2 Protein refseq:NP_055610.1
LIMK1 Protein refseq:NP_002305.1
CFL1 Protein refseq:NP_005498.1
ITGAL Protein refseq:NP_002200.2
ITGB2 Protein refseq:NP_000202.3
TGFB1 Protein ncbigene:4313
IL10 Protein refseq:NP_000563.1
PIK3R3 Protein refseq:NP_003620.3
PIK3R1 Protein refseq:NP_852556.2
CDH2 Protein refseq:NP_001783.2
VEGFC Protein refseq:NP_005420.1
MMP2 Protein refseq:NP_004521.1
FZD4 Protein refseq:NP_036325.2
PTEN Protein refseq:NP_000305.3
CCL18 Protein refseq:NP_002979.1
CDC25C Protein refseq:NP_001781.2
LDHA Protein ncbiprotein:NP_005557.1
LDHB Protein refseq:NP_002291.1
ARNT Protein ncbigene:205

References

  1. CCL18-mediated down-regulation of miR98 and miR27b promotes breast cancer metastasis. Lin X, Chen L, Yao Y, Zhao R, Cui X, Chen J, et al. Oncotarget. 2015 Aug 21;6(24):20485–99. PubMed Europe PMC Scholia