Aryl hydrocarbon receptor pathway (WP2873)
Homo sapiens
The aryl hydrocarbon receptor (AhR) is a transcription factor (part of the group of nuclear receptors) that responds to the presence of aromatic hydrocarbons. It regulates genes involved xenobiotic metabolism, e.g. cytochrome P450 enzymes. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2873 CPTAC Assay Portal]
Authors
Rianne Fijten , Egon Willighagen , Kristina Hanspers , Alex Pico , Marianthi Kalafati , Denise Slenter , and Eric WeitzActivity
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Cited In
- Early transcriptional responses of bronchial epithelial cells to whole cigarette smoke mirror those of in-vivo exposed human bronchial mucosa (2022).
- Commensal Microbiota Regulates Skin Barrier Function And Repair Via Signaling Through The Aryl Hydrocarbon Receptor (2021).
- LMWF5A suppresses cytokine release by modulating select inflammatory transcription factor activity in stimulated PBMC (2020).
- Gene expression profiling reveals aryl hydrocarbon receptor as a possible target for photobiomodulation when using blue light (2016).
- SARS-CoV-2 induces “cytokine storm” hyperinflammatory responses in RA patients through pyroptosis (2022).
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
regulatory pathway aryl hydrocarbon receptor signaling pathwayReferences
- Aryl hydrocarbon receptor-mediated signal transduction. Rowlands JC, Gustafsson JA. Crit Rev Toxicol. 1997 Mar;27(2):109–34. PubMed Europe PMC Scholia
- The murine IL-2 promoter contains distal regulatory elements responsive to the Ah receptor, a member of the evolutionarily conserved bHLH-PAS transcription factor family. Jeon MS, Esser C. J Immunol. 2000 Dec 15;165(12):6975–83. PubMed Europe PMC Scholia
- Functional role of AhR in the expression of toxic effects by TCDD. Mimura J, Fujii-Kuriyama Y. Biochim Biophys Acta. 2003 Feb 17;1619(3):263–8. PubMed Europe PMC Scholia
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces insulin-like growth factor binding protein-1 gene expression and counteracts the negative effect of insulin. Marchand A, Tomkiewicz C, Marchandeau JP, Boitier E, Barouki R, Garlatti M. Mol Pharmacol. 2005 Feb;67(2):444–52. PubMed Europe PMC Scholia
- Subchronic exposure to TCDD, PeCDF, PCB126, and PCB153: effect on hepatic gene expression. Vezina CM, Walker NJ, Olson JR. Environ Health Perspect. 2004 Nov;112(16):1636–44. PubMed Europe PMC Scholia
- TCDD induces c-jun expression via a novel Ah (dioxin) receptor-mediated p38-MAPK-dependent pathway. Weiss C, Faust D, Dürk H, Kolluri SK, Pelzer A, Schneider S, et al. Oncogene. 2005 Jul 21;24(31):4975–83. PubMed Europe PMC Scholia
- Over-production of IFN-gamma and IL-12 in AhR-null mice. Rodríguez-Sosa M, Elizondo G, López-Durán RM, Rivera I, Gonzalez FJ, Vega L. FEBS Lett. 2005 Nov 21;579(28):6403–10. PubMed Europe PMC Scholia
- Ah receptor: dioxin-mediated toxic responses as hints to deregulated physiologic functions. Bock KW, Köhle C. Biochem Pharmacol. 2006 Aug 14;72(4):393–404. PubMed Europe PMC Scholia
- Coordinate regulation of Phase I and II xenobiotic metabolisms by the Ah receptor and Nrf2. Köhle C, Bock KW. Biochem Pharmacol. 2007 Jun 15;73(12):1853–62. PubMed Europe PMC Scholia
- AHR- and DNA-damage-mediated gene expression responses induced by benzo(a)pyrene in human cell lines. Hockley SL, Arlt VM, Brewer D, Te Poele R, Workman P, Giddings I, et al. Chem Res Toxicol. 2007 Dec;20(12):1797–810. PubMed Europe PMC Scholia
- TCDD deregulates contact inhibition in rat liver oval cells via Ah receptor, JunD and cyclin A. Weiss C, Faust D, Schreck I, Ruff A, Farwerck T, Melenberg A, et al. Oncogene. 2008 Apr 3;27(15):2198–207. PubMed Europe PMC Scholia
- Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues. Pavek P, Dvorak Z. Curr Drug Metab. 2008 Feb;9(2):129–43. PubMed Europe PMC Scholia
- Growth factors, cytokines and their receptors as downstream targets of arylhydrocarbon receptor (AhR) signaling pathways. Haarmann-Stemmann T, Bothe H, Abel J. Biochem Pharmacol. 2009 Feb 15;77(4):508–20. PubMed Europe PMC Scholia
- Involvement of aryl hydrocarbon receptor in basal and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced expression of target genes in primary human hepatocytes. Le Vee M, Jouan E, Fardel O. Toxicol In Vitro. 2010 Sep;24(6):1775–81. PubMed Europe PMC Scholia
- The aryl hydrocarbon receptor (AHR) transcription factor regulates megakaryocytic polyploidization. Lindsey S, Papoutsakis ET. Br J Haematol. 2011 Feb;152(4):469–84. PubMed Europe PMC Scholia
- From differential induction of UDP-glucuronosyltransferases in rat liver to characterization of responsible ligand-activated transcription factors, and their multilevel crosstalk in humans. Bock KW. Biochem Pharmacol. 2011 Jul 1;82(1):9–16. PubMed Europe PMC Scholia
- Pathways for ligand activated nuclear receptors to unravel the genomic responses induced by hepatotoxicants. Fijten RRR, Jennen DGJ, van Delft JHM. Curr Drug Metab. 2013 Dec;14(10):1022–8. PubMed Europe PMC Scholia