Striated muscle contraction pathway (WP383)
Homo sapiens
Muscle contraction is the process where muscle tissue is activated by a signal from the nervous system. In the case of voluntary action, the nervous signals are initiated from the brain by so-called action potentials. With reflexes, these potentials are coming directly from the spinal cord. Striated muscles are a group of muscles also called skeletal and cardiac muscle tissue. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.
For a description of pathway objects, see the WikiPathways Legend.
Authors
Nathan Salomonis , Martijn Van Iersel , Joanna Fong , Kristina Hanspers , Andra Waagmeester , Marianthi Kalafati , Marvin Martens , Friederike Ehrhart , Eric Weitz , Martina Summer-Kutmon , and Egon WillighagenActivity
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Cited In
- PolySTest: Robust Statistical Testing of Proteomics Data with Missing Values Improves Detection of Biologically Relevant Features (2020).
- SARS-CoV-2 infection of human iPSC-derived cardiac cells predicts novel cytopathic features in hearts of COVID-19 patients (2020).
- Hematopoietic stem-cell senescence and myocardial repair - Coronary artery disease genotype/phenotype analysis of post-MI myocardial regeneration response induced by CABG/CD133+ bone marrow hematopoietic stem cell treatment in RCT PERFECT Phase 3 (2020).
- Parallel use of human stem cell lung and heart models provide insights for SARS-CoV-2 treatment (2023).
- Proteomics analysis of the non-muscle myosin heavy chain IIa-enriched actin-myosin complex reveals multiple functions within the podocyte (2014).
- Identification of potential mutations and genomic alterations in the epithelial and spindle cell components of biphasic synovial sarcomas using a human exome SNP chip (2015).
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Organisms
Homo sapiensCommunities
Annotations
Cell Type Ontology
striated muscle cellPathway Ontology
regulatory pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| TNNI3 | GeneProduct | ncbigene:7137 | |
| DES | GeneProduct | ncbigene:1674 | |
| MYBPC1 | GeneProduct | ncbigene:4604 | |
| TCAP | GeneProduct | ncbigene:8557 | |
| TNNI1 | GeneProduct | ncbigene:7135 | |
| MYOM1 | GeneProduct | ncbigene:8736 | |
| ACTA2 | GeneProduct | ncbigene:59 | |
| ACTG1 | GeneProduct | ncbigene:71 | |
| TNNT1 | GeneProduct | ncbigene:7138 | |
| ACTA1 | GeneProduct | ncbigene:58 | |
| MYL4 | GeneProduct | ncbigene:4635 | |
| TNNI2 | GeneProduct | ncbigene:7136 | |
| MYBPC3 | GeneProduct | ncbigene:4607 | |
| MYH6 | GeneProduct | ncbigene:4624 | |
| TNNC1 | GeneProduct | ncbigene:7134 | |
| TPM2 | GeneProduct | ncbigene:7169 | |
| TNNC2 | GeneProduct | ncbigene:7125 | |
| VIM | GeneProduct | ncbigene:7431 | |
| TPM3 | GeneProduct | ncbigene:7170 | |
| MYL3 | GeneProduct | ncbigene:4634 | MLEV HUMAN |
| MYL2 | GeneProduct | ncbigene:4633 | |
| NEB | GeneProduct | ncbigene:4703 | |
| ACTN3 | GeneProduct | ncbigene:89 | AAC3 MOUSE |
| MYH8 | GeneProduct | ncbigene:4626 | |
| ACTC | GeneProduct | ncbigene:70 | |
| MYH3 | GeneProduct | ncbigene:4621 | |
| TPM4 | GeneProduct | ncbigene:7171 | |
| TTN | GeneProduct | ncbigene:7273 | similiar to hs: Q10465 |
| TNNT3 | GeneProduct | ncbigene:7140 | |
| TNNT2 | GeneProduct | ncbigene:7139 | |
| MYL9 | GeneProduct | ncbigene:10398 | |
| MYBPC2 | GeneProduct | ncbigene:4606 | |
| DMD | GeneProduct | ncbigene:1756 | |
| ACTN4 | GeneProduct | ncbigene:81 | |
| TMOD1 | GeneProduct | ncbigene:7111 | |
| ACTN2 | GeneProduct | ncbigene:88 | AAC2 MOUSE |
| TPM1 | GeneProduct | ncbigene:7168 | p10469 |
| MYL1 | GeneProduct | ncbigene:4632 |