Amino acid metabolism (WP3925)

Homo sapiens

A complete overview of the metabolism of all 20 amino acids. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3925 CPTAC Assay Portal]

Authors

Kristina Hanspers , Egon Willighagen , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

amino acid metabolic pathway

Participants

Label Type Compact URI Comment
Ethanol Metabolite hmdb:HMDB0000108
Methionine Metabolite hmdb:HMDB0000696
Indoleacetate Metabolite hmdb:HMDB0000197
Aconitate Metabolite hmdb:HMDB0000072
Oxaloacetate Metabolite hmdb:HMDB0000223
Aspartate Metabolite hmdb:HMDB0000191
Leucine Metabolite hmdb:HMDB0000687
Urea Metabolite hmdb:HMDB0000294
Fumarate Metabolite hmdb:HMDB0000134
isocitrate Metabolite hmdb:HMDB0000193
Citrate Metabolite hmdb:HMDB0000094
methylhistamine Metabolite hmdb:HMDB0000898
Dopamine Metabolite hmdb:HMDB0000073
Cystathionine Metabolite hmdb:HMDB0000099
Carbamoyl-aspartate Metabolite hmdb:HMDB0000828
Histidine Metabolite hmdb:HMDB0000177
Pyruvate Metabolite hmdb:HMDB0000243
5-OH-Trp Metabolite hmdb:HMDB0000472
B-OH-butyrate Metabolite hmdb:HMDB0000011
Glutamine Metabolite hmdb:HMDB0000641
Glucose Metabolite hmdb:HMDB0000122
Creatine P Metabolite hmdb:HMDB0001511
Threonine Metabolite hmdb:HMDB0000167
Glycine Metabolite hmdb:HMDB0000123
Isoleucine Metabolite hmdb:HMDB0000172
Arginine Metabolite hmdb:HMDB0000517
Histamine Metabolite hmdb:HMDB0000870
Melanin Metabolite hmdb:HMDB0004068
Tyrosine Metabolite hmdb:HMDB0000158
Ornithine Metabolite hmdb:HMDB0000214
hydroxy-proline Metabolite hmdb:HMDB0000725
mercaptopyruvate Metabolite hmdb:HMDB0001368
Alanine Metabolite hmdb:HMDB0000161
Asparagine Metabolite hmdb:HMDB0000168
Homocysteine Metabolite hmdb:HMDB0000742
Tryptamine Metabolite hmdb:HMDB0000303
carbamoyl-P Metabolite hmdb:HMDB0001096
Succinyl-CoA Metabolite hmdb:HMDB0001022
Citrulline Metabolite hmdb:HMDB0000904
Cysteine Metabolite hmdb:HMDB0000574
Thyroxine Metabolite hmdb:HMDB0000248
Spermidine Metabolite hmdb:HMDB0001257
oxo-isocaproate Metabolite chebi:17865
Serine Metabolite hmdb:HMDB0000187
Spermine Metabolite hmdb:HMDB0001256
Tryptophan Metabolite hmdb:HMDB0000929
Oxobutyrate Metabolite hmdb:HMDB0000005
P-enolpyruvate Metabolite hmdb:HMDB0000263
Guanidinoacetate P Metabolite hmdb:HMDB0003705
Lactate Metabolite hmdb:HMDB0000190
OH-indoleacetate Metabolite hmdb:HMDB0000763
methylmalonyl-CoA Metabolite chebi:15465
Guanidinoacetate Metabolite hmdb:HMDB0000128
Succinate Metabolite hmdb:HMDB0000254
valine Metabolite hmdb:HMDB0000883
Phenylalanine Metabolite hmdb:HMDB0000159
oxo-methyl-valerate Metabolite chebi:35146
oxo-isovalerate Metabolite chebi:11851
Putrescine Metabolite hmdb:HMDB0001414
methylmalonate semialdehyde Metabolite chebi:16256
Serotonin Metabolite hmdb:HMDB0000259
Dihydro-orotate Metabolite hmdb:HMDB0003349
Glutamate Metabolite hmdb:HMDB0000148
Malate Metabolite hmdb:HMDB0000156
Proline Metabolite hmdb:HMDB0000162
Indoleacetaldehyde Metabolite hmdb:HMDB0001190
HCO3 Metabolite hmdb:HMDB0003538
NADP Metabolite hmdb:HMDB0000217
Met-tRNA Metabolite chebi:16635
Arginino-succinate Metabolite hmdb:HMDB0000052
N-Formylkynurenine Metabolite hmdb:HMDB0001200
Arg-tRNA Metabolite chebi:18366
Ala-tRNA Metabolite chebi:17732
Trp-tRNA Metabolite chebi:29159
isobutyryl-CoA Metabolite chebi:15479
Val-tRNA Metabolite chebi:29164
Leu-tRNA Metabolite chebi:16624
Ile-tRNA Metabolite chebi:29160
Isovaleryl-CoA Metabolite hmdb:HMDB0001113
Methylbutyryl-CoA Metabolite hmdb:HMDB0001041
Acetyl-CoA Metabolite hmdb:HMDB0001206
OH-methylglutaryl-CoA Metabolite hmdb:HMDB0001375
methacrylyl-CoA Metabolite chebi:27754
OH-isobutyrate Metabolite chebi:19641
Tiglyl-CoA Metabolite hmdb:HMDB0002054
OH-isovaleryl-CoA Metabolite hmdb:HMDB0006870
Methylacetoacetyl-CoA Metabolite hmdb:HMDB0001157
OH-isobutyryl-CoA Metabolite hmdb:HMDB0001052
Methylcrotonyl-CoA Metabolite hmdb:HMDB0001493
Methyl-OH-butyryl-CoA Metabolite hmdb:HMDB0001356
Propionyl-CoA Metabolite hmdb:HMDB0001275
Methylglutaconyl-CoA Metabolite hmdb:HMDB0001057
His-tRNA Metabolite chebi:29155
pyrroline carboxylate Metabolite hmdb:HMDB0006875
Glu-tRNA Metabolite chebi:29157
glutamate semialdehyde Metabolite chebi:15757
glutamyl-P Metabolite chebi:21314
Imidazole acetaldehyde Metabolite hmdb:HMDB0003905
2-oxo-glutarate Metabolite chebi:16810
glutamyl-cysteine Metabolite chebi:17515
Red. Glutathione Metabolite hmdb:HMDB0000125
R-S-glutathione Metabolite chebi:17021
Ox. glutathione Metabolite hmdb:HMDB0003337
Phe-tRNA Metabolite chebi:29153
homogentisate Metabolite chebi:16169
Epinephrine Metabolite hmdb:HMDB0000068
Norepinephrine Metabolite hmdb:HMDB0000216
Tyr-tRNA Metabolite chebi:29161
GSR GeneProduct ensembl:ENSG00000104687 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95804
HDC GeneProduct ensembl:ENSG00000140287 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96062
CBS GeneProduct ensembl:ENSG00000160200 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:88285
SMS GeneProduct ensembl:ENSG00000102172 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:109490
MDH1 GeneProduct ensembl:ENSG00000014641 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97051
PKM GeneProduct ensembl:ENSG00000067225 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97591
ASS1 GeneProduct ensembl:ENSG00000130707 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:88090
AOC3 GeneProduct ensembl:ENSG00000131471 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1306797
EPRS GeneProduct ensembl:ENSG00000136628 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97838
DLD GeneProduct ensembl:ENSG00000091140 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:107450
PCK1 GeneProduct ensembl:ENSG00000124253 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97501
GLUD1 GeneProduct ensembl:ENSG00000148672 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95753
HMGCS2 GeneProduct ensembl:ENSG00000134240 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:101939
HNMT GeneProduct ensembl:ENSG00000150540 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2153181
DDC GeneProduct ensembl:ENSG00000132437 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:94876
ACADM GeneProduct ensembl:ENSG00000117054 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:87867
GOT2 GeneProduct ensembl:ENSG00000125166 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95792
AUH GeneProduct ensembl:ENSG00000148090 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1338011
PDK4 GeneProduct ensembl:ENSG00000004799 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1351481
AC007325.2 GeneProduct ensembl:ENSG00000277196 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19125
DLST GeneProduct ensembl:ENSG00000119689 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1926170
FAH GeneProduct ensembl:ENSG00000103876 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95482
EHHADH GeneProduct ensembl:ENSG00000113790 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1277964
HAL GeneProduct ensembl:ENSG00000084110 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96010
IARS GeneProduct ensembl:ENSG00000196305 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2145219
ALDH1A1 GeneProduct ensembl:ENSG00000165092 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1353450
HIBCH GeneProduct ensembl:ENSG00000198130 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1923792
TAT GeneProduct ensembl:ENSG00000198650 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:98487
CAD GeneProduct ensembl:ENSG00000084774 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1916969
MARS2 GeneProduct ensembl:ENSG00000247626 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2444136
BHMT GeneProduct ensembl:ENSG00000145692 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1339972
BCAT1 GeneProduct ensembl:ENSG00000060982 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:104861
ACAA1 GeneProduct ensembl:ENSG00000060971 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2148491
HIBADH GeneProduct ensembl:ENSG00000106049 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1889802
GPT2 GeneProduct ensembl:ENSG00000166123 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1915391
P4HA2 GeneProduct ensembl:ENSG00000072682 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:894286
PDHA1 GeneProduct ensembl:ENSG00000131828 Homology Mapping from Mus musculus to Homo sapiens: Original ID = U:Mm.34775
TPO GeneProduct ensembl:ENSG00000115705 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:98813
GCLM GeneProduct ensembl:ENSG00000023909 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:104995
ADH5 GeneProduct ensembl:ENSG00000197894 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:87929
OAT GeneProduct ensembl:ENSG00000065154 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97394
PPM1L GeneProduct ensembl:ENSG00000163590 Homology Mapping from Mus musculus to Homo sapiens: Original ID = U:Mm.40577
ADH4 GeneProduct ensembl:ENSG00000198099 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1349472
MAOA GeneProduct ensembl:ENSG00000189221 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96915
TH GeneProduct ensembl:ENSG00000180176 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:98735
SDS GeneProduct ensembl:ENSG00000135094 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:98270
LARS2 GeneProduct ensembl:ENSG00000011376 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2142973
G6PC2 GeneProduct ensembl:ENSG00000152254 Homology Mapping from Mus musculus to Homo sapiens: Original ID = U:Mm.140768
WARS GeneProduct ensembl:ENSG00000140105 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:104630
LDHA GeneProduct ensembl:ENSG00000134333 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96759
ADH1C GeneProduct ensembl:ENSG00000248144 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:87921
GLS GeneProduct ensembl:ENSG00000115419 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95752
SDHA GeneProduct ensembl:ENSG00000073578 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1914195
FARSB GeneProduct ensembl:ENSG00000116120 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1346035
ASNS GeneProduct ensembl:ENSG00000070669 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1350929
ALDH7A1 GeneProduct ensembl:ENSG00000164904 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:108186
MPST GeneProduct ensembl:ENSG00000128309 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2179733
SUCLG1 GeneProduct ensembl:ENSG00000163541 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1927234
HMGCL GeneProduct ensembl:ENSG00000117305 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96158
ADH7 GeneProduct ensembl:ENSG00000196344 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:87926
PC GeneProduct ensembl:ENSG00000173599 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97520
PYCR1 GeneProduct ensembl:ENSG00000183010 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:2384795
OGDH GeneProduct ensembl:ENSG00000105953 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18293
AC068533.7 GeneProduct ensembl:ENSG00000249319 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:88084
GSS GeneProduct ensembl:ENSG00000100983 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95852
FH GeneProduct ensembl:ENSG00000091483 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14194
CTH GeneProduct ensembl:ENSG00000116761 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1339968
TPH1 GeneProduct ensembl:ENSG00000129167 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:98796
MUT GeneProduct ensembl:ENSG00000146085 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97239
ARG1 GeneProduct ensembl:ENSG00000118520 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:88070
MDH2 GeneProduct ensembl:ENSG00000146701 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97050
IDH1 GeneProduct ensembl:ENSG00000138413 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96413
PNMT GeneProduct ensembl:ENSG00000141744 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97724
DBH GeneProduct ensembl:ENSG00000123454 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:94864
ACO2 GeneProduct ensembl:ENSG00000100412 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:87880
GLUL GeneProduct ensembl:ENSG00000135821 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95739
RARS GeneProduct ensembl:ENSG00000113643 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1914297
MCCC1 GeneProduct ensembl:ENSG00000078070 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1919289
ODC1 GeneProduct ensembl:ENSG00000115758 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97402
FTCD GeneProduct ensembl:ENSG00000160282 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1339962
ALDH18A1 GeneProduct ensembl:ENSG00000059573 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1888908
GOT1 GeneProduct ensembl:ENSG00000120053 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:95791
CS GeneProduct ensembl:ENSG00000062485 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:88529
ACLY GeneProduct ensembl:ENSG00000131473 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:103251
VARS GeneProduct ensembl:ENSG00000204394 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:90675
PDHX GeneProduct ensembl:ENSG00000110435 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1351627
TDO2 GeneProduct ensembl:ENSG00000151790 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1928486
OTC GeneProduct ensembl:ENSG00000036473 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:97448
AP002884.2 GeneProduct ensembl:ENSG00000255292 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1914175
ACSS1 GeneProduct ensembl:ENSG00000154930 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1915988
CPS1 GeneProduct ensembl:ENSG00000021826 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:891996
SRM GeneProduct ensembl:ENSG00000116649 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:102690
HADH GeneProduct ensembl:ENSG00000138796 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:96009
ARG2 GeneProduct ensembl:ENSG00000081181 Homology Mapping from Mus musculus to Homo sapiens: Original ID = M:MGI:1330806

References