Mitochondrial complex II assembly (WP4920)

Homo sapiens

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Complex II or succinate dehydrogenase (quinone) is shared between the TCA cycle and the ETC. It has no proton pumping activity. It is composed of four subunits encoded by nDNA. Two subunits are hydrophillic, SDHA and SDHB, and two subunits are hydrophobic: SDHC and SDHD. Complex II assembly occurs through the independent maturation of these subunits mediated by subunit-specific chaperones.

Authors

Anna Baya Meuleman , Egon Willighagen , and Eric Weitz

Activity

last edited

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Organisms

Homo sapiens

Communities

Serious Request 2024 - MetaKids

Annotations

Pathway Ontology

oxidative phosphorylation pathway electron transport chain pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
FAD Metabolite chebi:16238
SDHD GeneProduct ensembl:ENSG00000204370
SDHAF2 GeneProduct ensembl:ENSG00000167985
SDHB GeneProduct ensembl:ENSG00000117118
SDHA GeneProduct ensembl:ENSG00000073578
SDHC GeneProduct ensembl:ENSG00000143252
SDHAF1 GeneProduct ensembl:ENSG00000205138
SDHAF3 GeneProduct ensembl:ENSG00000196636
SDHAF4 GeneProduct ensembl:ENSG00000154079

References

  1. Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes. Signes A, Fernandez-Vizarra E. Essays Biochem. 2018 Jul 20;62(3):255–70. PubMed Europe PMC Scholia