Th17 cell differentiation pathway (WP5130)

Homo sapiens

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Th17 Cell differentiation and the effect of circadian network. The differentiation pathway for Th17 cell is considered and converted from the KEGG pathways database, whereas its connection with the circadian network is taken from the literature. All the references will be provided soon.

Authors

Hafeez-Ur-Rahman , Egon Willighagen , Kristina Hanspers , Lars Willighagen , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Cell Type Ontology

T-helper 17 cell

Pathway Ontology

immune response pathway signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
SOCS3 GeneProduct ensembl:ENSG00000184557
IL1B GeneProduct ensembl:ENSG00000125538
IRF4 GeneProduct ensembl:ENSG00000137265
IL22 GeneProduct ensembl:ENSG00000127318
HIF1A GeneProduct ensembl:ENSG00000100644
TGFBR1 GeneProduct ensembl:ENSG00000106799
IL6 GeneProduct ensembl:ENSG00000136244
IL23R GeneProduct ensembl:ENSG00000162594
JAK1/3 GeneProduct ensembl:ENSG00000162434
RORA GeneProduct ensembl:ENSG00000069667
IL6R GeneProduct ensembl:ENSG00000160712
IL21 GeneProduct ensembl:ENSG00000138684
PLCG1 GeneProduct ensembl:ENSG00000124181
RORC GeneProduct ensembl:ENSG00000143365 RORgt
IL1BR GeneProduct ensembl:ENSG00000125538
MAPK14 GeneProduct ensembl:ENSG00000112062 p38
HLA-DMA GeneProduct ensembl:ENSG00000204257
MTOR GeneProduct ensembl:ENSG00000198793
TGFB1 GeneProduct ensembl:ENSG00000105329
JAK1 GeneProduct ensembl:ENSG00000162434
IL23A GeneProduct ensembl:ENSG00000110944
IL21R GeneProduct ensembl:ENSG00000103522
TYK2 GeneProduct ensembl:ENSG00000105397
JAK2 GeneProduct ensembl:ENSG00000096968
HSP90AA1 GeneProduct ensembl:ENSG00000080824 Hsp90
STAT3 GeneProduct ensembl:ENSG00000168610
SMADs GeneProduct ensembl:ENSG00000175387
AHR GeneProduct ensembl:ENSG00000106546
IL17A GeneProduct ensembl:ENSG00000112115
IL17F GeneProduct ensembl:ENSG00000112116
NFKBIA GeneProduct ensembl:ENSG00000100906
JUN GeneProduct ensembl:ENSG00000177606
FOS GeneProduct ensembl:ENSG00000170345
NFKB1 GeneProduct ensembl:ENSG00000109320
NFATC1 GeneProduct ensembl:ENSG00000131196
JNK GeneProduct ensembl:ENSG00000107643
ERK GeneProduct ensembl:ENSG00000100030
PRKCQ GeneProduct ensembl:ENSG00000065675
ZAP70 GeneProduct ensembl:ENSG00000115085
LCK GeneProduct ensembl:ENSG00000182866
CD3Z GeneProduct ensembl:ENSG00000198821
IL4R GeneProduct ensembl:ENSG00000077238
IL4 GeneProduct ensembl:ENSG00000113520
LAT GeneProduct ensembl:ENSG00000213658
CD3E GeneProduct ensembl:ENSG00000198851
CD3D GeneProduct ensembl:ENSG00000167286
TCRB GeneProduct hgnc:12155
TCRA GeneProduct hgnc:12027
CD3G GeneProduct ensembl:ENSG00000160654
CD4 GeneProduct ensembl:ENSG00000010610
STAT6 GeneProduct ensembl:ENSG00000166888
CaN GeneProduct ensembl:ENSG00000138814
IKK GeneProduct ensembl:ENSG00000104365
GATA3 GeneProduct ensembl:ENSG00000107485
TBX21 GeneProduct ensembl:ENSG00000073861 T-bet
RUNX1 GeneProduct ensembl:ENSG00000159216
FOXP3 GeneProduct ensembl:ENSG00000049768
RXRA GeneProduct ensembl:ENSG00000186350
RARA GeneProduct ensembl:ENSG00000131759
STAT5A GeneProduct ensembl:ENSG00000126561
STAT1 GeneProduct ensembl:ENSG00000115415
IL2R GeneProduct ensembl:ENSG00000134460
IFNGR GeneProduct ensembl:ENSG00000027697
IL2 GeneProduct ensembl:ENSG00000109471
IFNG GeneProduct ensembl:ENSG00000111537
IL27R GeneProduct ensembl:ENSG00000104998
IL27 GeneProduct ensembl:ENSG00000197272
SMAD2 GeneProduct ensembl:ENSG00000175387
NFIL3 GeneProduct ensembl:ENSG00000165030
CRY1 GeneProduct ensembl:ENSG00000008405
PER1 GeneProduct ensembl:ENSG00000179094
NR1D1 GeneProduct ensembl:ENSG00000126368 Rev-erb
BMAL1 GeneProduct ensembl:ENSG00000133794
CLOCK GeneProduct ensembl:ENSG00000134852

References

  1. Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease. Sutton CE, Finlay CM, Raverdeau M, Early JO, DeCourcey J, Zaslona Z, et al. Nat Commun. 2017 Dec 12;8(1):1923. PubMed Europe PMC Scholia
  2. Down-regulation of aryl hydrocarbon receptor intensifies carcinogen-induced retinal lesion via SOCS3-STAT3 signaling. Tsai CH, Lee Y, Li CH, Cheng YW, Kang JJ. Cell Biol Toxicol. 2020 Jun;36(3):223–42. PubMed Europe PMC Scholia