Effect of omega-3 PUFA on Huntington's disease pathways (WP5470)

Homo sapiens

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These are pathways connected to both the wildtype huntingtin (HTT) gene and the mutated huntingtin (mHTT) gene related to neurodegeneration, apoptosis, cholesterol and GABA synthesis and its relation to Omega-3 polyunsaturated fatty acids.

Authors

KimberleyBijl , Eric Weitz , and Egon Willighagen

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Rare Diseases

Annotations

Disease Ontology

Huntington's disease

Cell Type Ontology

astrocyte oligodendrocyte neuron

Pathway Ontology

Huntington's disease pathway signaling pathway disease pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
PS Metabolite chebi:18303
Rapamycin Metabolite pubchem.compound:5497196
Glutamate Metabolite chebi:14321
DHA Metabolite lipidmaps:LMFA01030185
EPA Metabolite chebi:28364
DPA Metabolite chebi:61204
Glutamine Metabolite chebi:18050
Cl- Metabolite pubchem.compound:312
GABA Metabolite chebi:16865
Cholesterol Metabolite chebi:16113
24S-HC Metabolite chebi:34310
GABRA2 GeneProduct ensembl:ENSG00000151834
GABRA3 GeneProduct ensembl:ENSG00000011677
GABRA4 GeneProduct ensembl:ENSG00000109158
GABRA5 GeneProduct ensembl:ENSG00000186297
GABRA6 GeneProduct ensembl:ENSG00000145863
GABRB1 GeneProduct ensembl:ENSG00000163288
GABRB2 GeneProduct ensembl:ENSG00000145864
GABRB3 GeneProduct ensembl:ENSG00000166206
GABRG1 GeneProduct ensembl:ENSG00000163285
GABRG2 GeneProduct ensembl:ENSG00000113327
GABRG3 GeneProduct ensembl:ENSG00000182256
GABRE GeneProduct ensembl:ENSG00000102287
GABRP GeneProduct ensembl:ENSG00000094755
GABRD GeneProduct ensembl:ENSG00000187730
GABRQ GeneProduct ensembl:ENSG00000268089
PRKAA2 GeneProduct ensembl:ENSG00000162409
PRKAB1 GeneProduct ensembl:ENSG00000111725
PRKAB2 GeneProduct ensembl:ENSG00000131791
PRKAG1 GeneProduct ensembl:ENSG00000181929
PRKAG2 GeneProduct ensembl:ENSG00000106617
PRKAG3 GeneProduct ensembl:ENSG00000115592
PRKAA1 GeneProduct ensembl:ENSG00000132356
GABRA1 GeneProduct ensembl:ENSG00000022355
EGFR GeneProduct ensembl:ENSG00000146648
RAF1 GeneProduct ensembl:ENSG00000132155
MSK1 GeneProduct ensembl:ENSG00000100784
GRM1 GeneProduct ensembl:ENSG00000152822
BDNF GeneProduct ensembl:ENSG00000176697
ELK1 GeneProduct ensembl:ENSG00000126767
CREB GeneProduct ensembl:ENSG00000118260
NTRK2 GeneProduct ensembl:ENSG00000148053
EGF GeneProduct ensembl:ENSG00000138798
CASP3 GeneProduct ensembl:ENSG00000164305
CASP7 GeneProduct ensembl:ENSG00000165806
MAPK1 GeneProduct ensembl:ENSG00000100030
RAS GeneProduct ensembl:ENSG00000174775
HTT GeneProduct ensembl:ENSG00000197386 mutant Huntingtin
MAP2K1 GeneProduct ensembl:ENSG00000169032
MAP2K2 GeneProduct ensembl:ENSG00000126934
MAPK3 GeneProduct ensembl:ENSG00000102882
RAB3A GeneProduct ensembl:ENSG00000105649 mutant Huntingtin
RAB3GAP1 GeneProduct ensembl:ENSG00000115839 mutant Huntingtin
GABAaR GeneProduct ensembl:ENSG00000022355
KCC2 GeneProduct ensembl:ENSG00000124140
CKB GeneProduct ensembl:ENSG00000166165
IL1B GeneProduct ensembl:ENSG00000125538
TNF GeneProduct ensembl:ENSG00000228978
IL6 GeneProduct ensembl:ENSG00000136244
C1QA GeneProduct ensembl:ENSG00000173372
mHTT GeneProduct ensembl:ENSG00000197386 mutant Huntingtin
REST GeneProduct ensembl:ENSG00000084093
KIF5 GeneProduct ensembl:ENSG00000155980
HAP1 GeneProduct ensembl:ENSG00000173805
NKCC1 GeneProduct ensembl:ENSG00000064651
SP1 GeneProduct ensembl:ENSG00000185591 mutant Huntingtin
PI3K GeneProduct ensembl:ENSG00000124102
AKT GeneProduct ensembl:ENSG00000142208
REST/NRSF GeneProduct ensembl:ENSG00000084093
NRSE GeneProduct ensembl:ENSG00000084093
SIN3A GeneProduct ensembl:ENSG00000169375
HDAC1 GeneProduct ensembl:ENSG00000116478
HDAC2 GeneProduct ensembl:ENSG00000196591
BCL2 GeneProduct ensembl:ENSG00000171791
BAX GeneProduct ensembl:ENSG00000087088
BCL2L11 GeneProduct ensembl:ENSG00000153094
BCL-xL GeneProduct ensembl:ENSG00000171552
BAD GeneProduct ensembl:ENSG00000002330
BNIP3 GeneProduct ensembl:ENSG00000176171
OPA1 GeneProduct ensembl:ENSG00000198836
tBID GeneProduct ensembl:ENSG00000015475
BID GeneProduct ensembl:ENSG00000015475
CASP8 GeneProduct ensembl:ENSG00000064012
HAP1 GeneProduct ensembl:ENSG00000173805 mutant Huntingtin
AHI1 GeneProduct ensembl:ENSG00000135541 mutant Huntingtin
EGFR GeneProduct ensembl:ENSG00000146648 mutant Huntingtin
NEUROD1 GeneProduct ensembl:ENSG00000162992 mutant Huntingtin
MLK2 GeneProduct ensembl:ENSG00000130758 mutant Huntingtin
MAPKK7 GeneProduct ensembl:ENSG00000076984 mutant Huntingtin
MAPKK4 GeneProduct ensembl:ENSG00000065559 mutant Huntingtin
MAPK8 GeneProduct ensembl:ENSG00000107643 mutant Huntingtin
MAPK9 GeneProduct ensembl:ENSG00000050748 mutant Huntingtin
MAPK10 GeneProduct ensembl:ENSG00000109339 mutant Huntingtin
ITPR1 GeneProduct ensembl:ENSG00000150995 mutant Huntingtin
MTOR GeneProduct ensembl:ENSG00000198793
RAPTOR GeneProduct ensembl:ENSG00000141564
DEPTOR GeneProduct ensembl:ENSG00000155792
PRAS40 GeneProduct ensembl:ENSG00000204673
MLST8 GeneProduct ensembl:ENSG00000167965
RICTOR GeneProduct ensembl:ENSG00000164327
PROTOR GeneProduct ensembl:ENSG00000135362
TSC1 GeneProduct ensembl:ENSG00000165699
TSC2 GeneProduct ensembl:ENSG00000103197
S6K1 GeneProduct ensembl:ENSG00000108443
IKKβ GeneProduct ensembl:ENSG00000104365
RHEB GeneProduct ensembl:ENSG00000106615
AMPK GeneProduct ensembl:ENSG00000132356
4EBP1 GeneProduct ensembl:ENSG00000187840
TNF-Alpha GeneProduct ensembl:ENSG00000228978
EIF4E GeneProduct ensembl:ENSG00000151247
PTEN GeneProduct ensembl:ENSG00000171862
AKT1 GeneProduct ensembl:ENSG00000142208
AKT2 GeneProduct ensembl:ENSG00000105221
AKT3 GeneProduct ensembl:ENSG00000117020
HMGCS1 GeneProduct ensembl:ENSG00000112972
HMGCR GeneProduct ensembl:ENSG00000113161
HMGCS2 GeneProduct ensembl:ENSG00000134240
MBP GeneProduct ensembl:ENSG00000197971
DHCR7 GeneProduct ensembl:ENSG00000172893
PGC1a GeneProduct ensembl:ENSG00000109819
mHTT GeneProduct ensembl:ENSG00000197386
ABCG1 GeneProduct ensembl:ENSG00000160179
CYP46A1 GeneProduct ensembl:ENSG00000036530
LXR GeneProduct uniprot:P55055
ABCG4 GeneProduct ensembl:ENSG00000172350
APOE GeneProduct ensembl:ENSG00000130203
CYP51A1 GeneProduct ensembl:ENSG00000001630
ABCA1 GeneProduct ensembl:ENSG00000165029
SREBF2 GeneProduct ensembl:ENSG00000198911
PIK3CA GeneProduct ensembl:ENSG00000121879
PIK3CB GeneProduct ensembl:ENSG00000051382
PIK3CG GeneProduct ensembl:ENSG00000105851
PIK3CD GeneProduct ensembl:ENSG00000171608
PIK3R1 GeneProduct ensembl:ENSG00000145675
PIK3R2 GeneProduct ensembl:ENSG00000105647
PIK3R3 GeneProduct ensembl:ENSG00000117461
PIK3R4 GeneProduct ensembl:ENSG00000196455
PIK3R5 GeneProduct ensembl:ENSG00000141506
PIK3R6 GeneProduct ensembl:ENSG00000276231
PIK3C2A GeneProduct ensembl:ENSG00000011405
PIK3C2B GeneProduct ensembl:ENSG00000133056
PIK3C2G GeneProduct ensembl:ENSG00000139144
TrkB Protein ensembl:ENSG00000148053
NF-κB Protein ensembl:ENSG00000109320 mutant Huntingtin
BAD Protein ensembl:ENSG00000002330
SREBF2 Protein ensembl:ENSG00000198911
LXR Protein uniprot:P55055
PGC1a Protein ensembl:ENSG00000109819

References

  1. Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes. Zuccato C, Tartari M, Crotti A, Goffredo D, Valenza M, Conti L, et al. Nat Genet. 2003 Sep;35(1):76–83. PubMed Europe PMC Scholia
  2. Huntingtin associated protein 1 and its functions. Wu LL yan, Zhou XF. Cell Adh Migr. 2009;3(1):71–6. PubMed Europe PMC Scholia
  3. A novel target for Huntington’s disease: ERK at the crossroads of signaling. The ERK signaling pathway is implicated in Huntington’s disease and its upregulation ameliorates pathology. Bodai L, Marsh JL. Bioessays. 2012 Feb;34(2):142–8. PubMed Europe PMC Scholia
  4. Defining the role of the Bcl-2 family proteins in Huntington’s disease. Sassone J, Maraschi A, Sassone F, Silani V, Ciammola A. Cell Death Dis. 2013 Aug 15;4(8):e772. PubMed Europe PMC Scholia
  5. Study of cholesterol metabolism in Huntington’s disease. Leoni V, Caccia C. Biochem Biophys Res Commun. 2014 Apr 11;446(3):697–701. PubMed Europe PMC Scholia
  6. Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA, DPA and DHA. Dyall SC. Front Aging Neurosci. 2015 Apr 21;7:52. PubMed Europe PMC Scholia
  7. Mutant Huntingtin Impairs BDNF Release from Astrocytes by Disrupting Conversion of Rab3a-GTP into Rab3a-GDP. Hong Y, Zhao T, Li XJ, Li S. J Neurosci. 2016 Aug 24;36(34):8790–801. PubMed Europe PMC Scholia
  8. Targeting mTORs by omega-3 fatty acids: A possible novel therapeutic strategy for neurodegeneration? Shirooie S, Nabavi SF, Dehpour AR, Belwal T, Habtemariam S, Argüelles S, et al. Pharmacol Res. 2018 Sep;135:37–48. PubMed Europe PMC Scholia
  9. Insights into GABAAergic system alteration in Huntington’s disease. Hsu YT, Chang YG, Chern Y. Open Biol. 2018 Dec 5;8(12):180165. PubMed Europe PMC Scholia
  10. Molecular Pathophysiological Mechanisms in Huntington’s Disease. Jurcau A. Biomedicines. 2022 Jun 17;10(6):1432. PubMed Europe PMC Scholia