Selenium micronutrient network (WP3257)

Bos taurus

The selenium-centred micronutrient biological network. The most relevant biochemical processes related to selenium in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying the selenium centred plasma metabolome. A selenoprotein database exists at: http://www.selenodb.org

Authors

Martina Summer-Kutmon , Egon Willighagen , and Eric Weitz

Activity

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

selenoamino acid metabolic pathway classic metabolic pathway

Participants

Label Type Compact URI Comment
Lipoxin A4 Metabolite hmdb:HMDB0004385
PGD2 Metabolite hmdb:HMDB0001403 Prostaglandin D2
Arachidonic acid Metabolite hmdb:HMDB0001043
PGE1 Metabolite hmdb:HMDB0001442 Prostaglandin E1
Thromboxane B2 Metabolite hmdb:HMDB0003252
Lipoxin B4 Metabolite hmdb:HMDB0005082
Thromboxane A2 Metabolite hmdb:HMDB0001452
Linoleic acid Metabolite hmdb:HMDB0000673
a-Tocopherol Metabolite hmdb:HMDB0001893
F2-Isoprostane Metabolite wikidata:Q33659470
DHA Metabolite hmdb:HMDB0002183 Docosahexaenoic acid
8-Isoprostaglandin F2a Metabolite hmdb:HMDB0005083
PGI2 Metabolite hmdb:HMDB0001335 Prostaglandin I2
PGE2 Metabolite hmdb:HMDB0001220 Prostaglandin E2
MDA Metabolite hmdb:HMDB0006112 Malondialdehyde
PGF2a Metabolite hmdb:HMDB0001139 Prostaglandin F2a
ALA Metabolite hmdb:HMDB0001388 Alpha-Linolenic acid
EPA Metabolite hmdb:HMDB0001999 Eicosapentaenoic acid
DGLA Metabolite hmdb:HMDB0002925 Dihomo-gamma-linolenic acid
8,11,14-Eicosatrienoic acid
DPA Metabolite hmdb:HMDB0001976 Docosapentaenoic acid
PGH3 Metabolite hmdb:HMDB0013040 Prostaglandin H3
PGG2 Metabolite hmdb:HMDB0003235 Prostaglandin G2
PGH2 Metabolite hmdb:HMDB0001381 Prostaglandin H2
PGE3 Metabolite hmdb:HMDB0002664 Prostaglandin E3
Kynurenine Metabolite hmdb:HMDB0000684
Iodine Metabolite wikidata:Q1103
R-Triiodothyronine (rT3) Metabolite chebi:28774 Reverse triiodothyronine
Triiodothyronine (T3) Metabolite chebi:18258
15-HETE Metabolite hmdb:HMDB0003876 15S-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid
Thyroxine (T4) Metabolite chebi:30660
5-HPETE Metabolite hmdb:HMDB0001193 5(S)-Hydroperoxyeicosatetraenoic acid
5,6-Epoxytetraene Metabolite kegg.compound:C14815
5-HETE Metabolite hmdb:HMDB0011134 5-hydroxyeicosatetraenoic acid
NADP+ Metabolite hmdb:HMDB0000217 Nicotinamide adenine dinucleotide phosphate-Oxidized
Uric acid Metabolite hmdb:HMDB0000289
Cysteine Metabolite hmdb:HMDB0000574
H2O2 Metabolite hmdb:HMDB0003125 Hydrogen peroxide
Copper Metabolite hmdb:HMDB0000657
Vitamin B12 Metabolite hmdb:HMDB0002174
5,10-Methylene-THF Metabolite hmdb:HMDB0001533 5,10-Methylenetetrahydrofolate
Tryptophan Metabolite hmdb:HMDB0000929
5-methyl-THF Metabolite hmdb:HMDB0001396 5-methyltetrahydrofolate
H2O Metabolite hmdb:HMDB0002111 Glutathione disulfide
Niacinamide Metabolite hmdb:HMDB0001406
Heme Metabolite hmdb:HMDB0003178
NADPH Metabolite hmdb:HMDB0000221 Nicotinamide adenine dinucleotide phosphate-Reduced
Lipoic acid Metabolite hmdb:HMDB0001451
Manganese Metabolite hmdb:HMDB0001333
FAD Metabolite hmdb:HMDB0001248 Flavin adenine dinucleotide
Methionine sulfoxide Metabolite hmdb:HMDB0002005
Dehydroascorbic acid Metabolite chebi:17242
Leukotriene A4 Metabolite hmdb:HMDB0001337
THF Metabolite hmdb:HMDB0001846 Tetrahydrofolic acid
Hydroxykynurenine Metabolite hmdb:HMDB0000732
Folic acid Metabolite hmdb:HMDB0000121
Selenium Metabolite hmdb:HMDB0001349
GSH Metabolite hmdb:HMDB0000125 Glutathione
Calcium Metabolite hmdb:HMDB0000464
Methionine Metabolite hmdb:HMDB0000696
FMN Metabolite hmdb:HMDB0001520 Flavin Mononucleotide
Selenocysteine Metabolite hmdb:HMDB0003288
Selenide Metabolite chebi:15076
Selenophosphate Metabolite chebi:16144
Leukotriene C4 Metabolite hmdb:HMDB0001198
Ascorbic acid Metabolite chebi:29073
Homocysteine Metabolite hmdb:HMDB0000742
ROS Metabolite chebi:26523 reactive oxygen species
http://en.wikipedia.org/wiki/Reactive_Oxygen_Species
RNS Metabolite chebi:62764 reactive nitrogen species
http://en.wikipedia.org/wiki/Reactive_nitrogen_species
Pyridoxal 5'-phosphate Metabolite hmdb:HMDB0001491
Serine Metabolite hmdb:HMDB0000187
Iron Metabolite wikidata:Q26840996
Hypoxanthine Metabolite hmdb:HMDB0000157
VLDL Metabolite chebi:39027 very-low-density lipoprotein
LDL Metabolite chebi:39026 low-density lipoprotein
Cholesterol Metabolite hmdb:HMDB0000067
HDL Metabolite chebi:39025 high-density lipoprotein
VLDL-TAG Metabolite chebi:47776 very-low-density lipoprotein-triglyceride
Triglyceride transport
HDL-C Metabolite chebi:47775 high-density lipoprotein cholesterol
Cholesterol transport
TAG Metabolite chebi:17855 Triglyceride
Triacylglycerol
HDL-C Metabolite chebi:47775 high-density lipoprotein cholesterol
oxLDL Metabolite chebi:60151 oxidized low-density lipoprotein
HDL/APOA1 Metabolite chebi:39025 high-density lipoprotein
ApoA-I is present on the majority of HDL particles and constitutes aprox 70% of the apolipoprotein content of HDL particles
HDL/SAA Metabolite chebi:39025 high-density lipoprotein
SAA circulates in plasma as a constituent of high density lipoproteins (HDL).
VLDL/APOB Metabolite chebi:39027 very-low-density lipoprotein
The VLDL is produced in the liver, contains one molecule of apoB100
O2 Metabolite hmdb:HMDB0001377
8-OHdG Metabolite hmdb:HMDB0003333 8-Hydroxy-deoxyguanosine
ADP Metabolite hmdb:HMDB0001341 Adenosine diphosphate
Leukotriene D4 Metabolite hmdb:HMDB0003080
Chlorine Metabolite hmdb:HMDB0000492
Cystathionine Metabolite hmdb:HMDB0000099
Dihydrolipoate Metabolite hmdb:HMDB0012210
ATP Metabolite hmdb:HMDB0000538 Adenosine triphosphate
Zinc Metabolite hmdb:HMDB0015532
GSSG Metabolite hmdb:HMDB0000656 Glutathione disulfide
Niacin Metabolite hmdb:HMDB0001488
Leukotriene B4 Metabolite hmdb:HMDB0001085
Quinolinic Acid Metabolite hmdb:HMDB0000232
PMP Metabolite hmdb:HMDB0001555 Pyridoxamine 5'-phosphate
NO Metabolite hmdb:HMDB0003378 Nitric oxide
O3 Metabolite chebi:25812 ozone
HNO2 Metabolite chebi:25567 Nitrous acid
NO2 Metabolite chebi:33101 Nitrogen dioxide
HOCl Metabolite hmdb:HMDB0001050 Hypochlorite
Riboflavin Metabolite hmdb:HMDB0000244
Ascorbate Metabolite chebi:38290
O2-“ Metabolite hmdb:HMDB0002168 Superoxide
Xanthine Metabolite hmdb:HMDB0000292
Nitrotyrosine Metabolite hmdb:HMDB0001904
ONOO-/ONOOH Metabolite hmdb:HMDB0002179 Peroxynitrite
Leukotriene E4 Metabolite hmdb:HMDB0002200
Leukotriene F4 Metabolite hmdb:HMDB0006465
Glucose Metabolite hmdb:HMDB0000122
Fructosamine Metabolite hmdb:HMDB0002030
RELA GeneProduct ensembl:ENSBTAG00000013895 nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5970
NFKB1 GeneProduct ensembl:ENSBTAG00000020270 nuclear factor NF-kappa-B p50 subunit
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4790
NFKB2 GeneProduct ensembl:ENSBTAG00000006017 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4791
PTGS2 Protein ensembl:ENSBTAG00000014127 EC 1.14.99.1
Cyclooxygenase 2
COX-2 inducible
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5743
PTGS1 Protein ensembl:ENSBTAG00000006716 EC 1.14.99.1
Cyclooxygenase 1
COX-1 constitutive
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5742
MTR Protein ensembl:ENSBTAG00000012251 EC 2.1.1.13
5-methyltetrahydrofolate-homocysteine methyltransferase
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4548
TXNRD1 Protein ensembl:ENSBTAG00000013912 EC 1.8.1.9
Selenoprotein-thioredoxin reductase 1
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7296
CBS Protein ensembl:ENSBTAG00000000160 EC 4.2.1.22
cystathionine-beta-synthase
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:875
KMO Protein ensembl:ENSBTAG00000014439 EC 1.14.13.9
kynurenine 3-hydroxylase
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8564
MPO Protein ensembl:ENSBTAG00000011616 EC 1.11.1.7
Myeloperoxidase
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4353
CAT Protein ensembl:ENSBTAG00000020980 EC 1.11.1.6
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:847
F7 Protein ensembl:ENSBTAG00000007411 EC 3.4.21.21
coagulation factor VII (serum prothrombin conversion accelerator)
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2155
F2 Protein ensembl:ENSBTAG00000007148 EC 3.4.21.5
coagulation factor II (thrombin)
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2147
PLAT Protein ensembl:ENSBTAG00000001244 EC 3.4.21.68
plasminogen activator, tissue
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5327
SERPINE1 Protein ensembl:ENSBTAG00000014465 Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5054
PLG Protein ensembl:ENSBTAG00000001271 EC 3.4.21.7
Plasminogen
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5340
GGT1 Protein ensembl:ENSBTAG00000046900 EC 2.3.2.2
gamma-glutamyltransferase 1
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2678
GPX 4 Protein ensembl:ENSBTAG00000046926 EC 1.11.1.12
Selenoprotein-glutathione peroxidase 4
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2879
TXNRD2 Protein ensembl:ENSBTAG00000043581 EC 1.8.1.9
Selenoprotein-thioredoxin reductase 2
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10587
XDH Protein ensembl:ENSBTAG00000012519 EC 1.17.3.2
http://en.wikipedia.org/wiki/Xanthine_oxidase
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7498
PRDX5 Protein ensembl:ENSBTAG00000008648 EC 1.11.1.15
peroxiredoxin 5
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:25824
ALOX5 Protein ensembl:ENSBTAG00000020319 EC 1.13.11.34
arachidonate 5-lipoxygenase
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:240
ALOX15B Protein ensembl:ENSBTAG00000008779 EC 1.13.11.33
arachidonate 15-lipoxygenase, type B
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:247
SOD3 Protein ensembl:ENSBTAG00000013980 EC 1.15.1.1
superoxide dismutase 3, extracellular
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6649
PRDX1 Protein ensembl:ENSBTAG00000003642 EC 1.11.1.15
peroxiredoxin 1
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5052
RFK Protein ensembl:ENSBTAG00000019345 EC 2.7.1.26
riboflavin kinase
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:55312
GPX3 Protein ensembl:ENSBTAG00000043553 EC 1.11.1.9
Selenoprotein-glutathione peroxidase 3
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2878
CTH Protein ensembl:ENSBTAG00000014791 EC 4.4.1.1
cystathionase
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1491
PNPO Protein ensembl:ENSBTAG00000012259 EC 1.4.3.5
pyridoxamine 5'-phosphate oxidase
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:55163
SELENOK Protein ensembl:ENSBTAG00000032374 Selenoprotein-selenoprotein K
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:58515
GPX6 Protein ensembl:ENSBTAG00000012023 EC 1.11.1.9
Selenoprotein-glutathione peroxidase 6
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:257202
GPX3 Protein ensembl:ENSBTAG00000043553 Selenoprotein-glutathione peroxidase 3
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2878
GPX2 Protein ensembl:ENSBTAG00000048112 EC 1.11.1.9
Selenoprotein-glutathione peroxidase 2
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2877
PRDX4 Protein ensembl:ENSBTAG00000006165 EC 1.11.1.15
peroxiredoxin 4
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10549
MTHFR Protein ensembl:ENSBTAG00000020698 EC 1.5.1.20
5,10-methylenetetrahydrofolate reductase
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4524
SEPHS2 Protein ensembl:ENSBTAG00000010851 EC2.7.9.3
Selenoprotein-selenophosphate synthetase 2
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:22928
SELENOO Protein ensembl:ENSBTAG00000000647 Selenoprotein-selenoprotein O
Unknown function
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:83642
SELENON Protein ensembl:ENSBTAG00000021778 Selenoprotein-selenoprotein N, 1
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:57190
DIO2 Protein ensembl:ENSBTAG00000001605 EC 1.97.1.10
Selenoprotein-deiodinase, iodothyronine, type II
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1734
SELENOT Protein ensembl:ENSBTAG00000031435 Selenoprotein-selenoprotein T
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:51714
SELENOM Protein ensembl:ENSBTAG00000031279 Selenoprotein-selenoprotein M
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:140606
DIO3 Protein ensembl:ENSBTAG00000037977 EC 1.97.1.11
Selenoprotein-deiodinase, iodothyronine type III
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1735
DIO1 Protein ensembl:ENSBTAG00000010814 EC 1.97.1.10
Selenoprotein-deiodinase, iodothyronine, type I
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1733
SELENOV Protein ensembl:ENSBTAG00000010501 Selenoprotein-selenoprotein V
Unknown function
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:348303
SELENOI Protein ensembl:ENSBTAG00000007837 Selenoprotein-selenoprotein I
Unknown function
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:85465
SELENOS Protein ensembl:ENSBTAG00000000640 Selenoprotein-selenoprotein S
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:55829
SOD1 Protein ensembl:ENSBTAG00000027412 EC 1.15.1.1
superoxide dismutase 1, soluble
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6647
PRDX3 Protein ensembl:ENSBTAG00000008731 EC 1.11.1.15
peroxiredoxin 3
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10935
GSR Protein ensembl:ENSBTAG00000007115 EC 1.8.1.7
glutathione reductase
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:2936
APOA1 Protein ensembl:ENSBTAG00000002258 apolipoprotein A-I
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:335
APOB Protein ensembl:ENSBTAG00000008505 apolipoprotein B
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:338
LDLR Protein ensembl:ENSBTAG00000012314 low density lipoprotein receptor
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3949
SAA4 Protein ensembl:ENSBTAG00000002963 serum amyloid A4, constitutive
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6291
SCARB1 Protein ensembl:ENSBTAG00000014269 scavenger receptor class B, member 1
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:949
ABCA1 Protein ensembl:ENSBTAG00000020661 ATP-binding cassette, sub-family A (ABC1), member 1
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:19
APOA1 Protein ensembl:ENSBTAG00000002258 Nitrotyrosinated apolipoprotein A-I
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:335
SERPINA3-7 Protein ensembl:ENSBTAG00000026917 alpha-1-antichymotrypsin
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:12
PRDX2 Protein ensembl:ENSBTAG00000012062 EC 1.11.1.15
peroxiredoxin 2
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7001
SOD2 Protein ensembl:ENSBTAG00000006523 EC 1.15.1.1
superoxide dismutase 2, mitochondrial
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6648
ICAM1 Protein ensembl:ENSBTAG00000010303 soluble intercellular adhesion molecule 1
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3383
IFNG Protein ensembl:ENSBTAG00000012529 interferon, gamma
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3458
TNF Protein ensembl:ENSBTAG00000025471 tumor necrosis factor (TNF superfamily, member 2)
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7124
ALB Protein ensembl:ENSBTAG00000017121 albumin
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:213
IL1B Protein ensembl:ENSBTAG00000001321 interleukin 1, beta
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3553
INSR Protein ensembl:ENSBTAG00000012687 Insulin receptor
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3643
HBG Protein ensembl:ENSBTAG00000037644 hemoglobin, beta
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3043
CRP Protein ensembl:ENSBTAG00000013907 C-reactive protein, pentraxin-related
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1401
CCL2 Protein ensembl:ENSBTAG00000037811 chemokine (C-C motif) ligand 2
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6347
ALOX5AP Protein ensembl:ENSBTAG00000013201 arachidonate 5-lipoxygenase-activating protein
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:241
IL6 Protein ensembl:ENSBTAG00000014921 interleukin 6 (interferon, beta 2)
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3569
HBA Protein ensembl:ENSBTAG00000026418 hemoglobin, alpha 1
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:3039
SELENOW Protein ensembl:ENSBTAG00000008203 Selenoprotein-selenoprotein W
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6415
TXNRD1 Protein ensembl:ENSBTAG00000013912 Selenoprotein-thioredoxin reductase 1
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7296
KYNU Protein ensembl:ENSBTAG00000032277 EC 3.7.1.3
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8942
TXNRD3 Protein ensembl:ENSBTAG00000011795 EC 1.8.1.9
Selenoprotein-thioredoxin reductase 3
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:114112
FLAD1 Protein ensembl:ENSBTAG00000000186 EC 2.7.7.2
FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)
Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:80308

References

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