Amino acid metabolism in triple-negative breast cancer cells (WP5213)

Homo sapiens

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Amino acid metabolism in triple-negative breast cancer cells. The glutamine, serine and glycine metabolic pathways are significantly upregulated. The upregulated expression of key genes within the glutamine, serine and glycine metabolic pathways have also been observed in triple-negative breast cancer cells

Authors

Andra Waagmeester , Egon Willighagen , Martina Summer-Kutmon , and Eric Weitz

Activity

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Organisms

Homo sapiens

Communities

CPTAC

Annotations

Disease Ontology

breast cancer triple-receptor negative breast cancer amino acid metabolic disorder

Pathway Ontology

cancer pathway glycine metabolic pathway glutamine metabolic pathway amino acid metabolic pathway serine metabolic pathway disease pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
glucose Metabolite wikidata:Q37525
CB-839 Metabolite wikidata:Q27075751
glutamine Metabolite pubchem.compound:5961
reduced glutathione Metabolite pubchem.compound:124886
3-phospho-glycerate Metabolite pubchem.compound:724
serine Metabolite pubchem.compound:5951
sulfasalazine Metabolite pubchem.compound:5339
NH3 Metabolite pubchem.compound:222
glycine Metabolite pubchem.compound:753
malate Metabolite pubchem.compound:160434
phosphohydroxypyruvate Metabolite pubchem.compound:5460375
phosphoserine Metabolite pubchem.compound:68841
pyruvate Metabolite pubchem.compound:107735
glutamine Metabolite pubchem.compound:5961
cystine Metabolite pubchem.compound:595
glutamate Metabolite pubchem.compound:33032
α-ketoglutarate Metabolite pubchem.compound:51
oxaloacetate Metabolite pubchem.compound:970
citrate Metabolite pubchem.compound:31348
PSPH GeneProduct ncbigene:5723
SLC1A5 GeneProduct ncbigene:6510
GLS GeneProduct ncbigene:2744
SHMT GeneProduct eccode:2.1.2.1
GLUT1 GeneProduct ncbigene:6513
PSAT1 GeneProduct ncbigene:29968
Aminotransferase GeneProduct pfam:PF00155
SLC7A11 GeneProduct ncbigene:23657
PHGDH GeneProduct ncbigene:26227

References

  1. Serine, but Not Glycine, Supports One-Carbon Metabolism and Proliferation of Cancer Cells. Labuschagne CF, van den Broek NJF, Mackay GM, Vousden KH, Maddocks ODK. Cell Reports [Internet]. 2014 May;7(4):1248–58. Available from: http://dx.doi.org/10.1016/j.celrep.2014.04.045 DOI Scholia
  2. Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia. Kung HN, Marks JR, Chi JT. PLoS Genet. 2011 Aug;7(8):e1002229. PubMed Europe PMC Scholia
  3. Differential expression of enzymes associated with serine/glycine metabolism in different breast cancer subtypes. Kim SK, Jung WH, Koo JS. PLoS One. 2014 Jun 30;9(6):e101004. PubMed Europe PMC Scholia
  4. Amino Acid transporters in cancer and their relevance to “glutamine addiction”: novel targets for the design of a new class of anticancer drugs. Bhutia YD, Babu E, Ramachandran S, Ganapathy V. Cancer Res. 2015 May 1;75(9):1782–8. PubMed Europe PMC Scholia
  5. Metabolic reprogramming in triple-negative breast cancer. Wang Z, Jiang Q, Dong C. Cancer Biol Med. 2020 Feb 15;17(1):44–59. PubMed Europe PMC Scholia