EGF/EGFR signaling pathway (WP978)

Bos taurus

Epidermal growth factor receptor (EGFR) also known as ErbB1/HER1 is a member of the ErbB family of receptor tyrosine kinases which also includes ErbB2 (Neu, HER2), ErbB3 (HER3) and ErbB4 (HER4). Several ligands such as epidermal growth factor, transforming growth factor-alpha, epigen, amphiregulin, betacellulin, heparin-binding EGF and epiregulin are known to specifically bind to EGFR. Epidermal growth factor (EGF) is one of the high affinity ligands of EGFR. EGF/EGFR system induces growth, differentiation, migration, adhesion and cell survival through various inter-acting signaling pathways. The binding of EGF to the extracellular domain of EGFR induces the dimerization, activation of intrinsic kinase activity and subsequent autophosphorylation of EGFR at multiple residues in the cytoplasmic region such as Tyr 1092, Tyr 1172, Tyr 1197, Tyr 1110, Tyr 1016). Activated EGFR recruits various cytoplasmic proteins which transduce and regulate the EGFR function. The proteins recruited to active EGFR include many Src homology 2 (SH2) and phosphotyrosine binding (PTB) domain containing proteins which binds to the tyrosine phosphorylated residues in EGFR, enzymes which act on EGFR and also various EGFR substrates. One of the adapter proteins, GRB2, binds to the phosphotyrosine residue at 1068 and recruits SOS to the membrane. SOS activates GDP/GTP exchange which recruits RAF to the membrane. RAF phosphorylates MEKs, which then activates the extracellular signal regulated kinase (ERK). ERK activates a number of transcriptional regulators to induce cell growth and proliferation. GRB2 or other adaptor proteins such as GABs recruits PI3Ks, another major mediator of EGFR signaling. PI3Ks convert Phosphatidylinositol-4,5-bisphosphate (PIP2) to Phosphatidylinositol-3,4,5-trisphosphate (PIP3). PIP3 binds to PH domain of AKT and recruits it to plasma membrane. PDK1 phosphorylates AKT which in turn regulate the activity of various proteins that mediate cell survival. EGFR also activate phospholipase C which hydrolyses PIP2 to generate Inositol trisphosphate (IP3) and 1,2-Diacylglycerol (DAG). IP3 induces the release of Ca2+ from endoplasmic reticulum to activate calcium regulated pathways. DAG activates protein kinase C pathway. One of the signaling modules regulated by PKC in EGFR pathway is the NFKB module. The protein SRC is a key player in the activation of various pathways such as RAS, PLC and also the STAT proteins in various cells. Other signaling modules activated by EGFR include the FAK, JNK, p38MAPK and ERK5 modules. EGFR induces the JNK pathway through the activation of G proteins such as RAC and CDC42 which recruits JNK kinases as well as regulate the actin polymerization. EGFR also translocates from the plasma membrane to other cellular compartments including nucleus where it directly regulate the expression of several genes in cooperation with other transcriptional regulators such as STATs, PCNA and E2F family of proteins. Being a growth, differentiation and cell survival factor; mutations and overexpression of EGFR and also the defective regulation of its signal transduction pathways has been established to be associated with oncogenesis. Thus, EGFR and its signaling components are promising targets for effective therapy for various cancers. There are several proteins which have been reported to regulate the EGFR signaling such as CBL, CSK, PKC and PTEN which promotes endocytosis or reduction in the EGFR activity or its signaling mediators. The major endocytic pathway of EGFR is established to be the clathrin coated pits which delivers them to endosomes. The endosomal pathway recycles the membraneous form of EGFR or form multivesicular bodies (MVB) and fuse with lysosomes for to the degradation pathway. Please access this pathway at [http://www.netpath.org/netslim/EGFR1_pathway.html NetSlim] database. If you use this pathway, please cite the following paper: Kandasamy, K., Mohan, S. S., Raju, R., Keerthikumar, S., Kumar, G. S. S., Venugopal, A. K., Telikicherla, D., Navarro, J. D., Mathivanan, S., Pecquet, C., Gollapudi, S. K., Tattikota, S. G., Mohan, S., Padhukasahasram, H., Subbannayya, Y., Goel, R., Jacob, H. K. C., Zhong, J., Sekhar, R., Nanjappa, V., Balakrishnan, L., Subbaiah, R., Ramachandra, Y. L., Rahiman, B. A., Prasad, T. S. K., Lin, J., Houtman, J. C. D., Desiderio, S., Renauld, J., Constantinescu, S. N., Ohara, O., Hirano, T., Kubo, M., Singh, S., Khatri, P., Draghici, S., Bader, G. D., Sander, C., Leonard, W. J. and Pandey, A. (2010). NetPath: A public resource of curated signal transduction pathways. Genome Biology. 11:R3.

Authors

Michiel Adriaens , Alex Pico , Christine Chichester , Martina Summer-Kutmon , Egon Willighagen , Eric Weitz , and Finterly Hu

Activity

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

epidermal growth factor/neuregulin signaling pathway

Participants

Label Type Compact URI Comment
NOS3 GeneProduct ensembl:ENSBTAG00000017680 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4846
COII GeneProduct ensembl:ENSBTAG00000043556 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4513
SHC1 Protein ensembl:ENSBTAG00000019838 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6464
STAT5A Protein ensembl:ENSBTAG00000009496 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6776
RALA Protein ensembl:ENSBTAG00000006661 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5898
NEDD4 Protein ensembl:ENSBTAG00000013793 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4734
ELK4 Protein ensembl:ENSBTAG00000004953 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2005
MAPK1 Protein ensembl:ENSBTAG00000010312 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
MAPK8 Protein ensembl:ENSBTAG00000007876 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5599
ARHGEF1 Protein ensembl:ENSBTAG00000018912 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9138
STMN1 Protein ensembl:ENSBTAG00000026505 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3925
STAT1 Protein ensembl:ENSBTAG00000007867 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772
EPS15L1 Protein ensembl:ENSBTAG00000009990 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:58513
SH3GL3 Protein ensembl:ENSBTAG00000018004 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6457
INPP5D Protein ensembl:ENSBTAG00000020173 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3635
PTPN5 Protein ensembl:ENSBTAG00000020257 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84867
ATF1 Protein ensembl:ENSBTAG00000018131 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:466
GRB10 Protein ensembl:ENSBTAG00000017086 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2887
ERRFI1 Protein ensembl:ENSBTAG00000006609 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54206
MAP3K1 Protein ensembl:ENSBTAG00000013790 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4214
PTK6 Protein ensembl:ENSBTAG00000044091 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5753
RPS6KA2 Protein ensembl:ENSBTAG00000021741 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6196
CSK Protein ensembl:ENSBTAG00000021424 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1445
PCNA Protein ensembl:ENSBTAG00000006065 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5111
LIMK2 Protein ensembl:ENSBTAG00000010662 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3985
RASA1 Protein ensembl:ENSBTAG00000009565 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5921
ARF6 Protein ensembl:ENSBTAG00000045980 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:382
IQGAP1 Protein ensembl:ENSBTAG00000013060 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8826
EGFR Protein ensembl:ENSBTAG00000011628 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1956
SP1 Protein ensembl:ENSBTAG00000003021 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6667
BRAF Protein ensembl:ENSBTAG00000021761 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:673
DOK2 Protein ensembl:ENSBTAG00000003341 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9046
PTPRR Protein ensembl:ENSBTAG00000015311 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5801
CRK Protein ensembl:ENSBTAG00000005665 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1398
SH2D2A Protein ensembl:ENSBTAG00000024470 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9047
MAPK9 Protein ensembl:ENSBTAG00000004709 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5601
RPS6KA3 Protein ensembl:ENSBTAG00000017639 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6197
RIN1 Protein ensembl:ENSBTAG00000017681 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9610
CAV2 Protein ensembl:ENSBTAG00000045584 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:858
E2F1 Protein ensembl:ENSBTAG00000003971 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1869
VAV2 Protein ensembl:ENSBTAG00000004511 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7410
SOS2 Protein ensembl:ENSBTAG00000005550 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6655
PTPN12 Protein ensembl:ENSBTAG00000003825 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5782
MTOR Protein ensembl:ENSBTAG00000015325 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2475
NCK2 Protein ensembl:ENSBTAG00000015205 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8440
MAP3K3 Protein ensembl:ENSBTAG00000008151 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4215
RALGDS Protein ensembl:ENSBTAG00000004194 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5900
VAV3 Protein ensembl:ENSBTAG00000031575 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10451
CAMK2A Protein ensembl:ENSBTAG00000020087 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:815
STAT3 Protein ensembl:ENSBTAG00000021523 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774
MAPK4 Protein ensembl:ENSBTAG00000009907 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5596
SOS1 Protein ensembl:ENSBTAG00000011643 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6654
RAP1A Protein ensembl:ENSBTAG00000014710 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5906
JAK1 Protein ensembl:ENSBTAG00000003147 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3716
CDC42 Protein ensembl:ENSBTAG00000001700 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:998
NCOA3 Protein ensembl:ENSBTAG00000007489 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8202
ATXN2 Protein ensembl:ENSBTAG00000022069 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6311
RAB5A Protein ensembl:ENSBTAG00000046385 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5868
RPS6KB1 Protein ensembl:ENSBTAG00000016851 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6198
MAPK14 Protein ensembl:ENSBTAG00000020783 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1432
ASAP1 Protein ensembl:ENSBTAG00000003185 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:50807
SYNJ1 Protein ensembl:ENSBTAG00000003063 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8867
MAP2K1 Protein ensembl:ENSBTAG00000033983 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604
RAF1 Protein ensembl:ENSBTAG00000045748 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894
EPN1 Protein ensembl:ENSBTAG00000046996 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:29924
NCK1 Protein ensembl:ENSBTAG00000018427 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4690
STAMBP Protein ensembl:ENSBTAG00000009600 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10617
CAV1 Protein ensembl:ENSBTAG00000017869 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:857
STAM2 Protein ensembl:ENSBTAG00000001887 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10254
HGS Protein ensembl:ENSBTAG00000000411 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9146
MAP2K2 Protein ensembl:ENSBTAG00000024450 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605
CREB1 Protein ensembl:ENSBTAG00000005474 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1385
PLCG1 Protein ensembl:ENSBTAG00000017584 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5335
ERBB2 Protein ensembl:ENSBTAG00000021798 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2064
SPRY2 Protein ensembl:ENSBTAG00000001774 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10253
INPPL1 Protein ensembl:ENSBTAG00000019167 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3636
EIF4EBP1 Protein ensembl:ENSBTAG00000027654 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1978
MAP4K1 Protein ensembl:ENSBTAG00000021145 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11184
RICTOR Protein ensembl:ENSBTAG00000006697 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:253260
USP6NL Protein ensembl:ENSBTAG00000019488 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9712
RPS6KA5 Protein ensembl:ENSBTAG00000010906 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9252
PTK2B Protein ensembl:ENSBTAG00000005958 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2185
PLD2 Protein ensembl:ENSBTAG00000013392 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5338
EPS8 Protein ensembl:ENSBTAG00000000369 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2059
RAC1 Protein ensembl:ENSBTAG00000009233 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5879
ABI1 Protein ensembl:ENSBTAG00000005136 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10006
PLSCR2 Protein ensembl:ENSBTAG00000022227 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5359
PIK3R1 Protein ensembl:ENSBTAG00000010989 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5295
MEF2D Protein ensembl:ENSBTAG00000046545 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4209
GAB1 Protein ensembl:ENSBTAG00000002813 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2549
PLCE1 Protein ensembl:ENSBTAG00000018966 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51196
PRKCSH Protein ensembl:ENSBTAG00000017490 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5337
DNM1 Protein ensembl:ENSBTAG00000011307 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1759
JUN Protein ensembl:ENSBTAG00000004037 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725
PIAS3 Protein ensembl:ENSBTAG00000021634 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10401
SH3GL2 Protein ensembl:ENSBTAG00000014103 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6456
RPS6KA1 Protein ensembl:ENSBTAG00000014447 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6195
ROCK1 Protein ensembl:ENSBTAG00000008403 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6093
MAP3K4 Protein ensembl:ENSBTAG00000020079 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4216
PRKCD Protein ensembl:ENSBTAG00000008719 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5580
AP2B1 Protein ensembl:ENSBTAG00000020316 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:163
AKT1 Protein ensembl:ENSBTAG00000017636 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207
FOXO1 Protein ensembl:ENSBTAG00000044105 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2308
VAV1 Protein ensembl:ENSBTAG00000039160 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7409
PRKCZ Protein ensembl:ENSBTAG00000014119 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5590
RALB Protein ensembl:ENSBTAG00000032021 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5899
FOS Protein ensembl:ENSBTAG00000004322 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2353
PRKCI Protein ensembl:ENSBTAG00000001403 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5584
PRKCA Protein ensembl:ENSBTAG00000001061 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5578
SRC Protein ensembl:ENSBTAG00000008938 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6714
ITCH Protein ensembl:ENSBTAG00000000308 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:83737
ABL1 Protein ensembl:ENSBTAG00000017976 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:25
RALBP1 Protein ensembl:ENSBTAG00000021250 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10928
MAPK7 Protein ensembl:ENSBTAG00000001014 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5598
REPS2 Protein ensembl:ENSBTAG00000031261 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9185
GRB2 Protein ensembl:ENSBTAG00000004736 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2885
EPS15 Protein ensembl:ENSBTAG00000005542 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2060
USP8 Protein ensembl:ENSBTAG00000011916 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9101
AP2A1 Protein ensembl:ENSBTAG00000019180 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:160
HRAS Protein ensembl:ENSBTAG00000046644 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265
PDPK1 Protein ensembl:ENSBTAG00000034436 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5170
IQSEC1 Protein ensembl:ENSBTAG00000003237 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9922
PEBP1 Protein ensembl:ENSBTAG00000018115 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5037
SH3KBP1 Protein ensembl:ENSBTAG00000003727 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:30011
TNK2 Protein ensembl:ENSBTAG00000021364 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10188
PTPN11 Protein ensembl:ENSBTAG00000002048 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5781
AP2S1 Protein ensembl:ENSBTAG00000010584 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1175
PRKCB Protein ensembl:ENSBTAG00000020921 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5579
FOXO4 Protein ensembl:ENSBTAG00000004879 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4303
FOSB Protein ensembl:ENSBTAG00000008182 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2354
PTEN Protein ensembl:ENSBTAG00000009498 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5728
NEDD8 Protein ensembl:ENSBTAG00000021446 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4738
STAM Protein ensembl:ENSBTAG00000002658 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8027
GJA1 Protein ensembl:ENSBTAG00000001835 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2697
CRKL Protein ensembl:ENSBTAG00000045548 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1399
JAK2 Protein ensembl:ENSBTAG00000012047 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3717
MAP2K5 Protein ensembl:ENSBTAG00000000218 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5607
BCAR1 Protein ensembl:ENSBTAG00000012002 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9564
MAP3K2 Protein ensembl:ENSBTAG00000004216 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10746
ELK1 Protein ensembl:ENSBTAG00000015817 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2002
STAT5B Protein ensembl:ENSBTAG00000010125 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6777
PIK3C2B Protein ensembl:ENSBTAG00000024633 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5287
STXBP1 Protein ensembl:ENSBTAG00000003525 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6812
CBLB Protein ensembl:ENSBTAG00000013057 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:868
CBL Protein ensembl:ENSBTAG00000006817 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:867
CBLC Protein ensembl:ENSBTAG00000009494 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23624
PAK1 Protein ensembl:ENSBTAG00000010191 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5058
CFL1 Protein ensembl:ENSBTAG00000021455 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1072
PTK2 Protein ensembl:ENSBTAG00000009578 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5747
AP2M1 Protein ensembl:ENSBTAG00000020106 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1173
MEF2A Protein ensembl:ENSBTAG00000010649 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4205
MEF2C Protein ensembl:ENSBTAG00000020701 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4208

References

  1. NetPath: a public resource of curated signal transduction pathways. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GSS, Venugopal AK, et al. Genome Biol. 2010 Jan 12;11(1):R3. PubMed Europe PMC Scholia