PPAR signaling pathway (WP4020)

Danio rerio

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake. Source: KEGG (http://www.genome.jp/dbget-bin/www_bget?pathway+dre03320)

Authors

Kristina Hanspers , Eric Weitz , and Egon Willighagen

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Danio rerio

Communities

Annotations

Pathway Ontology

peroxisome proliferator-activated receptor signaling pathway

Participants

Label Type Compact URI Comment
saturated fatty acids Metabolite chebi:26607
unsaturated fatty acids Metabolite chebi:27208
Clofibrate Metabolite hmdb:HMDB0014774
9-cis-Retinoic acid Metabolite hmdb:HMDB0002369
eicosanoid Metabolite chebi:23899
thiazolidinediones Metabolite chebi:50864 Should be thiazolidine derivative
VLDLChylomicron Metabolite chebi:6495
NSAIDs Metabolite chebi:35475
pparab GeneProduct zfin:ZDB-GENE-990415-211
cd36 GeneProduct zfin:ZDB-GENE-040718-55
pltp GeneProduct zfin:ZDB-GENE-040801-22
slc27a1a GeneProduct zfin:ZDB-GENE-050320-112
scd GeneProduct zfin:ZDB-GENE-031106-3
zgc:101540 GeneProduct zfin:ZDB-GENE-041212-67
slc27a4 GeneProduct zfin:ZDB-GENE-050417-248
apoa1a GeneProduct zfin:ZDB-GENE-990415-14
acox3 GeneProduct zfin:ZDB-GENE-040426-2163
slc27a6 GeneProduct zfin:ZDB-GENE-060825-27
fabp3 GeneProduct zfin:ZDB-GENE-020318-2
acadl GeneProduct zfin:ZDB-GENE-040426-771
slc27a1b GeneProduct zfin:ZDB-GENE-061013-672
angpt14 GeneProduct zfin:ZDB-GENE-041111-222
fabp2 GeneProduct zfin:ZDB-GENE-991019-5
fabp7b GeneProduct zfin:ZDB-GENE-040614-4
fabp6 GeneProduct zfin:ZDB-GENE-040625-49
fabp7a GeneProduct zfin:ZDB-GENE-000627-1
fabp1a GeneProduct zfin:ZDB-GENE-020318-3
rxrga GeneProduct zfin:ZDB-GENE-980526-36
fads2 GeneProduct zfin:ZDB-GENE-011212-1
cyp7a1 GeneProduct zfin:ZDB-GENE-040426-1296
cyp8b1 GeneProduct zfin:ZDB-GENE-040808-53
nr1h3 GeneProduct zfin:ZDB-GENE-050410-7
cyp27a1.4 GeneProduct zfin:ZDB-GENE-030131-1060
dbi GeneProduct zfin:ZDB-GENE-040426-1861
lpl GeneProduct zfin:ZDB-GENE-990415-139
acsbg1 GeneProduct zfin:ZDB-GENE-110914-219
acs14b GeneProduct zfin:ZDB-GENE-030131-6493
acsbg2 GeneProduct zfin:ZDB-GENE-030131-7099
acs14a GeneProduct zfin:ZDB-GENE-040426-1565
acs11b GeneProduct zfin:ZDB-GENE-040801-88
acs15 GeneProduct zfin:ZDB-GENE-040912-169
acs11a GeneProduct zfin:ZDB-GENE-050809-115
acs13b GeneProduct zfin:ZDB-GENE-030131-492
acs16 GeneProduct zfin:ZDB-GENE-030131-6776
acs13a GeneProduct zfin:ZDB-GENE-050420-181
si:dkey-91i10.3 GeneProduct zfin:ZDB-GENE-081105-124
cyp27a1.2 GeneProduct zfin:ZDB-GENE-081104-511
scdb GeneProduct zfin:ZDB-GENE-050522-12
ehhadh GeneProduct zfin:ZDB-GENE-040426-2581
cpt1aa GeneProduct zfin:ZDB-GENE-060503-925
cpt1ab GeneProduct zfin:ZDB-GENE-030131-3250
cpt2 GeneProduct zfin:ZDB-GENE-030131-6719
acaa1 GeneProduct zfin:ZDB-GENE-040704-48
scp2a GeneProduct zfin:ZDB-GENE-040426-1846
acox1 GeneProduct zfin:ZDB-GENE-041010-219
acadm GeneProduct zfin:ZDB-GENE-040426-1945
plin2 GeneProduct zfin:ZDB-GENE-050913-12
adipoqa GeneProduct zfin:ZDB-GENE-080423-2
adipoqb GeneProduct zfin:ZDB-GENE-060825-220
sorbs1 GeneProduct zfin:ZDB-GENE-090313-168
ilk GeneProduct zfin:ZDB-GENE-040426-1435
pdpk1b GeneProduct zfin:ZDB-GENE-040426-1820
si:ch211-202a12.4 GeneProduct zfin:ZDB-GENE-030131-8486
ubb GeneProduct zfin:ZDB-GENE-050411-10
ubc GeneProduct zfin:ZDB-GENE-061110-88
pck1 GeneProduct zfin:ZDB-GENE-030909-11
pck2 GeneProduct zfin:ZDB-GENE-040426-2266
aqp7 GeneProduct zfin:ZDB-GENE-030131-6461
zgc:172295 GeneProduct zfin:ZDB-GENE-080204-72

References

  1. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Desvergne B, Wahli W. Endocr Rev. 1999 Oct;20(5):649–88. PubMed Europe PMC Scholia
  2. The mode of action of thiazolidinediones. Hauner H. Diabetes Metab Res Rev. 2002;18 Suppl 2:S10-5. PubMed Europe PMC Scholia
  3. Peroxisome proliferator-activated receptor alpha target genes. Mandard S, Müller M, Kersten S. Cell Mol Life Sci. 2004 Feb;61(4):393–416. PubMed Europe PMC Scholia
  4. PPAR gamma as a metabolic regulator: insights from genomics and pharmacology. Savage DB. Expert Rev Mol Med. 2005 Jan 25;7(1):1–16. PubMed Europe PMC Scholia
  5. The structures and functions of peroxisome proliferator-activated receptors (PPARs). Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T. Nihon Rinsho. 2005 Apr;63(4):557–64. PubMed Europe PMC Scholia
  6. PPARs-mediated intracellular signal transduction. Fujii H. Nihon Rinsho. 2005 Apr;63(4):565–71. PubMed Europe PMC Scholia
  7. PPARs target genes. Takada I, Kato S. Nihon Rinsho. 2005 Apr;63(4):573–7. PubMed Europe PMC Scholia
  8. Endogenous ligands for PPARs. Inoue H. Nihon Rinsho. 2005 Apr;63(4):578–83. PubMed Europe PMC Scholia
  9. The many faces of PPARgamma. Lehrke M, Lazar MA. Cell. 2005 Dec 16;123(6):993–9. PubMed Europe PMC Scholia
  10. From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions. Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W. Prog Lipid Res. 2006 Mar;45(2):120–59. PubMed Europe PMC Scholia
  11. PPAR gamma and human metabolic disease. Semple RK, Chatterjee VKK, O’Rahilly S. J Clin Invest. 2006 Mar;116(3):581–9. PubMed Europe PMC Scholia
  12. Transcriptional regulation of metabolism. Desvergne B, Michalik L, Wahli W. Physiol Rev. 2006 Apr;86(2):465–514. PubMed Europe PMC Scholia