FAS pathway and stress induction of HSP regulation (WP902)

Pan troglodytes

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This pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta].

Authors

Thomas Kelder , Kristina Hanspers , Christine Chichester , Egon Willighagen , and Eric Weitz

Activity

last edited

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Organisms

Pan troglodytes

Communities

Annotations

Pathway Ontology

FasL mediated signaling pathway stress response pathway

Participants

Label Type Compact URI Comment
Phosphate Metabolite hmdb:HMDB0001429
Glutathione Metabolite hmdb:HMDB0000125
Ceramide Metabolite cas:104404-17-3
SPTAN1 GeneProduct ncbigene:464771 Interim Symbol: Spna1 predicted and Name: spectrin alpha 1 (predicted)
IL1A GeneProduct ncbigene:470485
FAF1 GeneProduct ncbigene:456846
CASP7 GeneProduct ncbigene:450745
HSPB1 GeneProduct ncbigene:463488
RIPK2 GeneProduct ncbigene:464277 receptor (TNFRSF)-interacting serine-threonine kinase 2
DFFB GeneProduct ncbigene:744932
PAK1 GeneProduct ncbigene:451439
APAF1 GeneProduct ncbigene:452153
DAXX GeneProduct ncbigene:462613
MAPKAPK2 GeneProduct ncbigene:744091
CASP8 GeneProduct ncbigene:746477
DFFA GeneProduct ncbigene:457928
ARHGDIB GeneProduct ncbigene:742002 Interim Symbol: Arhgdib predicted and Name: Rho, GDP dissociation inhibitor (GDI) beta (predicted)
FASLG GeneProduct ncbigene:469584
FADD GeneProduct ncbigene:451389
RB1 GeneProduct ncbigene:452715
MAPK8 GeneProduct ncbigene:450445
JUN GeneProduct ncbigene:456893
MAPKAPK3 GeneProduct ncbigene:460400
MAP2K4 GeneProduct ncbigene:455065
CASP6 GeneProduct ncbigene:736606
PAK2 GeneProduct ncbigene:460965
MAP3K7 GeneProduct ncbigene:462888
LMNB1 GeneProduct ncbigene:462035
CASP9 GeneProduct ncbigene:456457
CFLAR GeneProduct ncbigene:459872
BCL2 GeneProduct ncbigene:738409
MAP3K1 GeneProduct ncbigene:471543
CASP3 GeneProduct ncbigene:461669
TNF GeneProduct ncbigene:494186
PRKDC GeneProduct ncbigene:464165
LMNA GeneProduct ncbigene:457385
FAS GeneProduct ncbigene:738331

References

  1. Heat shock proteins--modulators of apoptosis in tumour cells. Creagh EM, Sheehan D, Cotter TG. Leukemia. 2000 Jul;14(7):1161–73. PubMed Europe PMC Scholia